Effect of irradiation on malignant tumour invasion into bone

Objective: The periosteum acts as a protective harrier against the entry of tumour cells during direct bone invasion of malignant tumours. Injuries to the periosteum may cause impairment of its barrier function. The effect of irradiation on tumour bone invasion was examined using a mouse tumour tran...

Full description

Saved in:
Bibliographic Details
Main Authors: Kathawut Tachasuttirut, Shogo Hasegawa, Norio Yoshino, Daisuke Ito, Ken Omura
Format: Journal
Published: 2018
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=65349110541&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/60309
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-60309
record_format dspace
spelling th-cmuir.6653943832-603092018-09-10T03:47:21Z Effect of irradiation on malignant tumour invasion into bone Kathawut Tachasuttirut Shogo Hasegawa Norio Yoshino Daisuke Ito Ken Omura Dentistry Medicine Objective: The periosteum acts as a protective harrier against the entry of tumour cells during direct bone invasion of malignant tumours. Injuries to the periosteum may cause impairment of its barrier function. The effect of irradiation on tumour bone invasion was examined using a mouse tumour transplantation model. Materials and Methods: Forty four C57BU6J mice were used to evaluate the effect of irradiation. The calvarias of the mice were scratched and/or irradiated (dose, 10 Gy), and B16F10 melanoma cells were inoculated. Mice from the irradiation only group were inoculated with B16F10 cells 1, 7 or 14 days after irradiation, and the association of irradiation effects with this duration was evaluated. Calvaria specimens were radiologically and histologically evaluated, and the quantity of bone resorption was examined Results: Bone invasion was not evident in non-irradiated non-scratched control mice, even whe the tumour size reached 15 to 20 mm. However, cortical bone resorption and tumour cell entry were observed in both irradiation only and scratch only groups. More aggressive invasion of B16F10 was found in irradiation plus scratch calvarias. Evaluation based on sagittal suture opening revealed no significant differences in bone invasion among these groups Conclusions: Injuries caused by irradiation made the periosteum more prone to malignant tumour invasion. The effect of irradiation on bones might be long lasting. © 2008 Asian Association of Oral and Maxillofacial Surgeons. 2018-09-10T03:40:52Z 2018-09-10T03:40:52Z 2008-01-01 Journal 09156992 2-s2.0-65349110541 10.1016/S0915-6992(08)80031-3 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=65349110541&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/60309
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Dentistry
Medicine
spellingShingle Dentistry
Medicine
Kathawut Tachasuttirut
Shogo Hasegawa
Norio Yoshino
Daisuke Ito
Ken Omura
Effect of irradiation on malignant tumour invasion into bone
description Objective: The periosteum acts as a protective harrier against the entry of tumour cells during direct bone invasion of malignant tumours. Injuries to the periosteum may cause impairment of its barrier function. The effect of irradiation on tumour bone invasion was examined using a mouse tumour transplantation model. Materials and Methods: Forty four C57BU6J mice were used to evaluate the effect of irradiation. The calvarias of the mice were scratched and/or irradiated (dose, 10 Gy), and B16F10 melanoma cells were inoculated. Mice from the irradiation only group were inoculated with B16F10 cells 1, 7 or 14 days after irradiation, and the association of irradiation effects with this duration was evaluated. Calvaria specimens were radiologically and histologically evaluated, and the quantity of bone resorption was examined Results: Bone invasion was not evident in non-irradiated non-scratched control mice, even whe the tumour size reached 15 to 20 mm. However, cortical bone resorption and tumour cell entry were observed in both irradiation only and scratch only groups. More aggressive invasion of B16F10 was found in irradiation plus scratch calvarias. Evaluation based on sagittal suture opening revealed no significant differences in bone invasion among these groups Conclusions: Injuries caused by irradiation made the periosteum more prone to malignant tumour invasion. The effect of irradiation on bones might be long lasting. © 2008 Asian Association of Oral and Maxillofacial Surgeons.
format Journal
author Kathawut Tachasuttirut
Shogo Hasegawa
Norio Yoshino
Daisuke Ito
Ken Omura
author_facet Kathawut Tachasuttirut
Shogo Hasegawa
Norio Yoshino
Daisuke Ito
Ken Omura
author_sort Kathawut Tachasuttirut
title Effect of irradiation on malignant tumour invasion into bone
title_short Effect of irradiation on malignant tumour invasion into bone
title_full Effect of irradiation on malignant tumour invasion into bone
title_fullStr Effect of irradiation on malignant tumour invasion into bone
title_full_unstemmed Effect of irradiation on malignant tumour invasion into bone
title_sort effect of irradiation on malignant tumour invasion into bone
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=65349110541&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/60309
_version_ 1681425412042784768