Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing

In this work, the sodium salt of 2-acrylamido-2-methylpropanesulfonic acid (Na-AMPS) was photopolymerised in aqueous solution with ethylene glycol dimethacrylate (EGDM) added as a crosslinking agent and 4,4'-azo-bis(4- cyanopentanoic acid) as the water-soluble photoinitiator. The aqueous soluti...

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Main Authors: C. Witthayaprapakorn, R. Molloy, K. Nalampang, B. J. Tighe
Format: Book Series
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/60386
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-603862018-09-10T03:41:49Z Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing C. Witthayaprapakorn R. Molloy K. Nalampang B. J. Tighe Engineering In this work, the sodium salt of 2-acrylamido-2-methylpropanesulfonic acid (Na-AMPS) was photopolymerised in aqueous solution with ethylene glycol dimethacrylate (EGDM) added as a crosslinking agent and 4,4'-azo-bis(4- cyanopentanoic acid) as the water-soluble photoinitiator. The aqueous solution was poured into a vertical sheet-forming mould consisting of two parallel plates covered with Teflon® sheets as release liners. Spacers were used to control the sheet thickness with a polymer mesh inserted in the middle to strengthen the hydrogel. The hydrogel sheets obtained were of 1.2 ± 0.2 mm thickness and showed good transparency, flexibility and skin adhesion. On immersion in distilled water at 37°C, it was found that the equilibrium water content (EWC) reached 98 ± 1% within 20 mins following which the equilibrium water retention (EWR) in ambient air was 21 ± 1% over a period of about 4 hrs. The water vapour transmission rate (WVTR) was measured at 37 °C and was found to be 82 ± 2 g m -2 hr -1. It is concluded that this Na-AMPS hydrogel sheet has properties which show potential for biomedical use as a wound dressing. © 2008 Trans Tech Publications, Switzerland. 2018-09-10T03:41:49Z 2018-09-10T03:41:49Z 2008-12-01 Book Series 10226680 2-s2.0-62949182277 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=62949182277&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/60386
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Engineering
spellingShingle Engineering
C. Witthayaprapakorn
R. Molloy
K. Nalampang
B. J. Tighe
Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing
description In this work, the sodium salt of 2-acrylamido-2-methylpropanesulfonic acid (Na-AMPS) was photopolymerised in aqueous solution with ethylene glycol dimethacrylate (EGDM) added as a crosslinking agent and 4,4'-azo-bis(4- cyanopentanoic acid) as the water-soluble photoinitiator. The aqueous solution was poured into a vertical sheet-forming mould consisting of two parallel plates covered with Teflon® sheets as release liners. Spacers were used to control the sheet thickness with a polymer mesh inserted in the middle to strengthen the hydrogel. The hydrogel sheets obtained were of 1.2 ± 0.2 mm thickness and showed good transparency, flexibility and skin adhesion. On immersion in distilled water at 37°C, it was found that the equilibrium water content (EWC) reached 98 ± 1% within 20 mins following which the equilibrium water retention (EWR) in ambient air was 21 ± 1% over a period of about 4 hrs. The water vapour transmission rate (WVTR) was measured at 37 °C and was found to be 82 ± 2 g m -2 hr -1. It is concluded that this Na-AMPS hydrogel sheet has properties which show potential for biomedical use as a wound dressing. © 2008 Trans Tech Publications, Switzerland.
format Book Series
author C. Witthayaprapakorn
R. Molloy
K. Nalampang
B. J. Tighe
author_facet C. Witthayaprapakorn
R. Molloy
K. Nalampang
B. J. Tighe
author_sort C. Witthayaprapakorn
title Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing
title_short Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing
title_full Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing
title_fullStr Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing
title_full_unstemmed Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing
title_sort design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=62949182277&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/60386
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