Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing
In this work, the sodium salt of 2-acrylamido-2-methylpropanesulfonic acid (Na-AMPS) was photopolymerised in aqueous solution with ethylene glycol dimethacrylate (EGDM) added as a crosslinking agent and 4,4'-azo-bis(4- cyanopentanoic acid) as the water-soluble photoinitiator. The aqueous soluti...
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th-cmuir.6653943832-603862018-09-10T03:41:49Z Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing C. Witthayaprapakorn R. Molloy K. Nalampang B. J. Tighe Engineering In this work, the sodium salt of 2-acrylamido-2-methylpropanesulfonic acid (Na-AMPS) was photopolymerised in aqueous solution with ethylene glycol dimethacrylate (EGDM) added as a crosslinking agent and 4,4'-azo-bis(4- cyanopentanoic acid) as the water-soluble photoinitiator. The aqueous solution was poured into a vertical sheet-forming mould consisting of two parallel plates covered with Teflon® sheets as release liners. Spacers were used to control the sheet thickness with a polymer mesh inserted in the middle to strengthen the hydrogel. The hydrogel sheets obtained were of 1.2 ± 0.2 mm thickness and showed good transparency, flexibility and skin adhesion. On immersion in distilled water at 37°C, it was found that the equilibrium water content (EWC) reached 98 ± 1% within 20 mins following which the equilibrium water retention (EWR) in ambient air was 21 ± 1% over a period of about 4 hrs. The water vapour transmission rate (WVTR) was measured at 37 °C and was found to be 82 ± 2 g m -2 hr -1. It is concluded that this Na-AMPS hydrogel sheet has properties which show potential for biomedical use as a wound dressing. © 2008 Trans Tech Publications, Switzerland. 2018-09-10T03:41:49Z 2018-09-10T03:41:49Z 2008-12-01 Book Series 10226680 2-s2.0-62949182277 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=62949182277&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/60386 |
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Engineering C. Witthayaprapakorn R. Molloy K. Nalampang B. J. Tighe Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing |
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In this work, the sodium salt of 2-acrylamido-2-methylpropanesulfonic acid (Na-AMPS) was photopolymerised in aqueous solution with ethylene glycol dimethacrylate (EGDM) added as a crosslinking agent and 4,4'-azo-bis(4- cyanopentanoic acid) as the water-soluble photoinitiator. The aqueous solution was poured into a vertical sheet-forming mould consisting of two parallel plates covered with Teflon® sheets as release liners. Spacers were used to control the sheet thickness with a polymer mesh inserted in the middle to strengthen the hydrogel. The hydrogel sheets obtained were of 1.2 ± 0.2 mm thickness and showed good transparency, flexibility and skin adhesion. On immersion in distilled water at 37°C, it was found that the equilibrium water content (EWC) reached 98 ± 1% within 20 mins following which the equilibrium water retention (EWR) in ambient air was 21 ± 1% over a period of about 4 hrs. The water vapour transmission rate (WVTR) was measured at 37 °C and was found to be 82 ± 2 g m -2 hr -1. It is concluded that this Na-AMPS hydrogel sheet has properties which show potential for biomedical use as a wound dressing. © 2008 Trans Tech Publications, Switzerland. |
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Book Series |
author |
C. Witthayaprapakorn R. Molloy K. Nalampang B. J. Tighe |
author_facet |
C. Witthayaprapakorn R. Molloy K. Nalampang B. J. Tighe |
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C. Witthayaprapakorn |
title |
Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing |
title_short |
Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing |
title_full |
Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing |
title_fullStr |
Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing |
title_full_unstemmed |
Design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing |
title_sort |
design and preparation of a bioresponsive hydrogel for biomedical application as a wound dressing |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=62949182277&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/60386 |
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