Assessment of a self-deferral form for screening blood donors, Chiang Mai University Hospital, Thailand

A self-deferral form has been used to screen Chiang Mai University Hospital blood donors and was improved in 2005. It has never been evaluated. The study aimed to assess the self-deferral form procedures in detecting infected donors. Sera from 5,083 donors, who passed the self-deferral screening for...

Full description

Saved in:
Bibliographic Details
Main Authors: Lakkana Thaikruea, Niwes Nantachit, Nipapan Leetrakool, Ladda Fongsatitkul, Prakai Sompan, Andrew Heaton, Kenrad E. Nelson
Format: Journal
Published: 2018
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=52649155031&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/60604
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-60604
record_format dspace
spelling th-cmuir.6653943832-606042018-09-10T03:46:00Z Assessment of a self-deferral form for screening blood donors, Chiang Mai University Hospital, Thailand Lakkana Thaikruea Niwes Nantachit Nipapan Leetrakool Ladda Fongsatitkul Prakai Sompan Andrew Heaton Kenrad E. Nelson Medicine A self-deferral form has been used to screen Chiang Mai University Hospital blood donors and was improved in 2005. It has never been evaluated. The study aimed to assess the self-deferral form procedures in detecting infected donors. Sera from 5,083 donors, who passed the self-deferral screening form, were tested with the routine immuno-assays (serology) for HIV 1 and 2 antibodies, P24 antigen, HCV antibodies, HBV surface antigen, and syphilis. Antibody negative sera were also tested individually with the the Procleix Ultrio Assay for HIV-1 DNA, HCV RNA, and HBV DNA. The donors who had discrepant results between serology and NAT were evaluated with additional tests, including a more sensitive Alternative Nucleic Acid Test, AntiBcore IgM, AntiBcore IgG, HBsAg and Anti HBs. Among 5,083 donors, 331 (6.5%) had at least one positive marker. In multiple logistic regression analysis, the statistically significant factors (adjusted odds ratio and 95% Cl) for infection were age 30 years or below [1.45 (1.03, 2.03)], male gender [2.73 (1.64, 4.56)], primary school or lower education [1.56 (1.09, 2.23)], first-time donation [1.82 (1.25, 2.67)], and frequent donation [0.80 (0.70, 0.92)]. The safest donors were females, older than 30 years, with an education more than primary school, and frequent donation. Because of missing responses to some sensitive questions, there remains a need for further improvement of the self-deferral form. 2018-09-10T03:46:00Z 2018-09-10T03:46:00Z 2008-09-01 Journal 01251562 2-s2.0-52649155031 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=52649155031&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/60604
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Lakkana Thaikruea
Niwes Nantachit
Nipapan Leetrakool
Ladda Fongsatitkul
Prakai Sompan
Andrew Heaton
Kenrad E. Nelson
Assessment of a self-deferral form for screening blood donors, Chiang Mai University Hospital, Thailand
description A self-deferral form has been used to screen Chiang Mai University Hospital blood donors and was improved in 2005. It has never been evaluated. The study aimed to assess the self-deferral form procedures in detecting infected donors. Sera from 5,083 donors, who passed the self-deferral screening form, were tested with the routine immuno-assays (serology) for HIV 1 and 2 antibodies, P24 antigen, HCV antibodies, HBV surface antigen, and syphilis. Antibody negative sera were also tested individually with the the Procleix Ultrio Assay for HIV-1 DNA, HCV RNA, and HBV DNA. The donors who had discrepant results between serology and NAT were evaluated with additional tests, including a more sensitive Alternative Nucleic Acid Test, AntiBcore IgM, AntiBcore IgG, HBsAg and Anti HBs. Among 5,083 donors, 331 (6.5%) had at least one positive marker. In multiple logistic regression analysis, the statistically significant factors (adjusted odds ratio and 95% Cl) for infection were age 30 years or below [1.45 (1.03, 2.03)], male gender [2.73 (1.64, 4.56)], primary school or lower education [1.56 (1.09, 2.23)], first-time donation [1.82 (1.25, 2.67)], and frequent donation [0.80 (0.70, 0.92)]. The safest donors were females, older than 30 years, with an education more than primary school, and frequent donation. Because of missing responses to some sensitive questions, there remains a need for further improvement of the self-deferral form.
format Journal
author Lakkana Thaikruea
Niwes Nantachit
Nipapan Leetrakool
Ladda Fongsatitkul
Prakai Sompan
Andrew Heaton
Kenrad E. Nelson
author_facet Lakkana Thaikruea
Niwes Nantachit
Nipapan Leetrakool
Ladda Fongsatitkul
Prakai Sompan
Andrew Heaton
Kenrad E. Nelson
author_sort Lakkana Thaikruea
title Assessment of a self-deferral form for screening blood donors, Chiang Mai University Hospital, Thailand
title_short Assessment of a self-deferral form for screening blood donors, Chiang Mai University Hospital, Thailand
title_full Assessment of a self-deferral form for screening blood donors, Chiang Mai University Hospital, Thailand
title_fullStr Assessment of a self-deferral form for screening blood donors, Chiang Mai University Hospital, Thailand
title_full_unstemmed Assessment of a self-deferral form for screening blood donors, Chiang Mai University Hospital, Thailand
title_sort assessment of a self-deferral form for screening blood donors, chiang mai university hospital, thailand
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=52649155031&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/60604
_version_ 1681425466496385024