Pulmonary arterial hypertension in Thai patients with systemic sclerosis

Objective: Study the clinical features of pulmonary arterial hypertension (PAH) in Thai patients with systemic sclerosis (SSc), and compare these features between those with limited (lc) SSc and diffuse (dc) SSc. Material and Method: The medical records of SSc patients attending the Division of Rheu...

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Main Authors: Suparaporn Wangkaew, Nuntana Kasitanon, Arintaya Phrommintikul, Waraporn Sukitawut, Ramjai Wichainun, Worawit Louthrenoo
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/60672
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-606722018-09-10T03:46:59Z Pulmonary arterial hypertension in Thai patients with systemic sclerosis Suparaporn Wangkaew Nuntana Kasitanon Arintaya Phrommintikul Waraporn Sukitawut Ramjai Wichainun Worawit Louthrenoo Medicine Objective: Study the clinical features of pulmonary arterial hypertension (PAH) in Thai patients with systemic sclerosis (SSc), and compare these features between those with limited (lc) SSc and diffuse (dc) SSc. Material and Method: The medical records of SSc patients attending the Division of Rheumatology, Chiang Mai University were reviewed. PAH was defined by pulmonary arterial systolic pressure (PASP) > 35 mmHg, determined by Doppler echocardiography. Results: Among 275 patients with SSc, 66 had Doppler echocardiography measurement. Thirty-nine patients (59.1%) had PAH. Among the PAH-SSc patients, 36 (92.3%) presented with dyspnea on exertion, and 37 (94.8%) were in a New York Heart Association functional class of II and III. Twenty-four of 39 patients (61.5%) had interstitial lung disease. Diffuse SSc patients had a significantly higher proportion of males, and shorter disease duration between SSc and PAH diagnosis than lcSSc patients. Conclusion: PAH was not uncommon in Thai patients with SSc. Interstitial lung disease might have been the cause associated with over half of these cases. Annual routine Doppler echocardiography screening for PAH in patients with SSc may detect preclinical PAH, and lead to early management and improved functional outcome. 2018-09-10T03:46:59Z 2018-09-10T03:46:59Z 2008-02-01 Journal 01252208 01252208 2-s2.0-40949084313 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=40949084313&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/60672
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Suparaporn Wangkaew
Nuntana Kasitanon
Arintaya Phrommintikul
Waraporn Sukitawut
Ramjai Wichainun
Worawit Louthrenoo
Pulmonary arterial hypertension in Thai patients with systemic sclerosis
description Objective: Study the clinical features of pulmonary arterial hypertension (PAH) in Thai patients with systemic sclerosis (SSc), and compare these features between those with limited (lc) SSc and diffuse (dc) SSc. Material and Method: The medical records of SSc patients attending the Division of Rheumatology, Chiang Mai University were reviewed. PAH was defined by pulmonary arterial systolic pressure (PASP) > 35 mmHg, determined by Doppler echocardiography. Results: Among 275 patients with SSc, 66 had Doppler echocardiography measurement. Thirty-nine patients (59.1%) had PAH. Among the PAH-SSc patients, 36 (92.3%) presented with dyspnea on exertion, and 37 (94.8%) were in a New York Heart Association functional class of II and III. Twenty-four of 39 patients (61.5%) had interstitial lung disease. Diffuse SSc patients had a significantly higher proportion of males, and shorter disease duration between SSc and PAH diagnosis than lcSSc patients. Conclusion: PAH was not uncommon in Thai patients with SSc. Interstitial lung disease might have been the cause associated with over half of these cases. Annual routine Doppler echocardiography screening for PAH in patients with SSc may detect preclinical PAH, and lead to early management and improved functional outcome.
format Journal
author Suparaporn Wangkaew
Nuntana Kasitanon
Arintaya Phrommintikul
Waraporn Sukitawut
Ramjai Wichainun
Worawit Louthrenoo
author_facet Suparaporn Wangkaew
Nuntana Kasitanon
Arintaya Phrommintikul
Waraporn Sukitawut
Ramjai Wichainun
Worawit Louthrenoo
author_sort Suparaporn Wangkaew
title Pulmonary arterial hypertension in Thai patients with systemic sclerosis
title_short Pulmonary arterial hypertension in Thai patients with systemic sclerosis
title_full Pulmonary arterial hypertension in Thai patients with systemic sclerosis
title_fullStr Pulmonary arterial hypertension in Thai patients with systemic sclerosis
title_full_unstemmed Pulmonary arterial hypertension in Thai patients with systemic sclerosis
title_sort pulmonary arterial hypertension in thai patients with systemic sclerosis
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=40949084313&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/60672
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