Development of highly stable and low toxic cationic liposomes for gene therapy

• Main Authors: Aranya Manosroi, Korakot Thathang, Rolf G. Werner, Rolf Schubert, Regine Peschka-Süss, Jiradej Manosroi
• Format: Journal
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=55949118239&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/60710
• Institution: Chiang Mai University

Cationic liposomes with high stability and low cytotoxicity for gene therapy have been developed. Luciferase plasmid DNA (pLuc) was used as a model gene. The empty liposomes and niosomes were prepared by freeze dried empty liposomes (FDEL) method. The entrapment of pLuc in the liposomes was by recon...