Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism

• Main Authors: Santosh K. Sandur, Manoj K. Pandey, Bokyung Sung, Kwang Seok Ahn, Akira Murakami, Gautam Sethi, Pornngarm Limtrakul, Vladimir Badmaev, Bharat B. Aggarwal
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34548058841&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/60897
• Institution: Chiang Mai University

Curcumin, a component of turmeric (Curcuma longa), has been shown to exhibit chemopreventive activity. Whether analogs of curcumin (Cur), such as demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC), tetrahydrocurcumin (THC) and turmerones, modulate inflammatory signaling and cell proliferation sign...