Magnetic resonance imaging of breast lesions - A pathologic correlation

Magnetic resonance imaging of the breast is useful in assessing breast lesions. An understanding of the pathologic characteristics of the tumors may help to understand these magnetic resonance imaging observations. Large lesional size (>10 mm), ill-defined margin, and irregular outlines are assoc...

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Main Authors: Gary M.K. Tse, Benjaporn Chaiwun, Ka Tak Wong, David K. Yeung, Amy L.M. Pang, Alice P.Y. Tang, Humairah S. Cheung
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/60905
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-609052018-09-10T04:08:14Z Magnetic resonance imaging of breast lesions - A pathologic correlation Gary M.K. Tse Benjaporn Chaiwun Ka Tak Wong David K. Yeung Amy L.M. Pang Alice P.Y. Tang Humairah S. Cheung Biochemistry, Genetics and Molecular Biology Medicine Magnetic resonance imaging of the breast is useful in assessing breast lesions. An understanding of the pathologic characteristics of the tumors may help to understand these magnetic resonance imaging observations. Large lesional size (>10 mm), ill-defined margin, and irregular outlines are associated with malignancy. These correlate with the pathological features of breast tumor, characterized by rapid growth rate, large size, and infiltrative growth pattern, invasion into stroma resulting in desmoplasia, and hence irregular outline and margin. The detection and estimation of tumor extent of invasive lobular carcinoma is problematic, even with magnetic resonance imaging, which is considered the most sensitivity. This inaccuracy likely derives from the characteristic linear, single cells infiltration growth pattern of the tumor, which is also often underestimated by clinical examination. Estimation of tumor extent after neoadjuvant chemotherapy is also essential but problematic by imaging, as the shrunken tumor becomes fibrotic, with stromal hyalinization, diminished microvasculature and tumor break up causing size underestimation. Non-enhancement of breast tumors occurs in about 8% of cases correlates with diffuse growth pattern, particularly of infiltrative lobular carcinoma. The observation of disproportionately high non-enhancing ductal carcinoma in situ remains an enigma. Finally, early rim enhancement correlates with small cancer nests, low ratio of peripheral to central fibrosis and high ratio of peripheral to central microvessel density. These may be related to increased vascular endothelial growth factor mediated increased microvessel density as well as increased permeability, which manifest as increased rapid contrast uptake and dissipation. © 2006 Springer Science+Business Media B.V. 2018-09-10T04:01:07Z 2018-09-10T04:01:07Z 2007-06-01 Journal 01676806 2-s2.0-34247501263 10.1007/s10549-006-9352-3 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34247501263&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/60905
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Medicine
spellingShingle Biochemistry, Genetics and Molecular Biology
Medicine
Gary M.K. Tse
Benjaporn Chaiwun
Ka Tak Wong
David K. Yeung
Amy L.M. Pang
Alice P.Y. Tang
Humairah S. Cheung
Magnetic resonance imaging of breast lesions - A pathologic correlation
description Magnetic resonance imaging of the breast is useful in assessing breast lesions. An understanding of the pathologic characteristics of the tumors may help to understand these magnetic resonance imaging observations. Large lesional size (>10 mm), ill-defined margin, and irregular outlines are associated with malignancy. These correlate with the pathological features of breast tumor, characterized by rapid growth rate, large size, and infiltrative growth pattern, invasion into stroma resulting in desmoplasia, and hence irregular outline and margin. The detection and estimation of tumor extent of invasive lobular carcinoma is problematic, even with magnetic resonance imaging, which is considered the most sensitivity. This inaccuracy likely derives from the characteristic linear, single cells infiltration growth pattern of the tumor, which is also often underestimated by clinical examination. Estimation of tumor extent after neoadjuvant chemotherapy is also essential but problematic by imaging, as the shrunken tumor becomes fibrotic, with stromal hyalinization, diminished microvasculature and tumor break up causing size underestimation. Non-enhancement of breast tumors occurs in about 8% of cases correlates with diffuse growth pattern, particularly of infiltrative lobular carcinoma. The observation of disproportionately high non-enhancing ductal carcinoma in situ remains an enigma. Finally, early rim enhancement correlates with small cancer nests, low ratio of peripheral to central fibrosis and high ratio of peripheral to central microvessel density. These may be related to increased vascular endothelial growth factor mediated increased microvessel density as well as increased permeability, which manifest as increased rapid contrast uptake and dissipation. © 2006 Springer Science+Business Media B.V.
format Journal
author Gary M.K. Tse
Benjaporn Chaiwun
Ka Tak Wong
David K. Yeung
Amy L.M. Pang
Alice P.Y. Tang
Humairah S. Cheung
author_facet Gary M.K. Tse
Benjaporn Chaiwun
Ka Tak Wong
David K. Yeung
Amy L.M. Pang
Alice P.Y. Tang
Humairah S. Cheung
author_sort Gary M.K. Tse
title Magnetic resonance imaging of breast lesions - A pathologic correlation
title_short Magnetic resonance imaging of breast lesions - A pathologic correlation
title_full Magnetic resonance imaging of breast lesions - A pathologic correlation
title_fullStr Magnetic resonance imaging of breast lesions - A pathologic correlation
title_full_unstemmed Magnetic resonance imaging of breast lesions - A pathologic correlation
title_sort magnetic resonance imaging of breast lesions - a pathologic correlation
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34247501263&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/60905
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