Comparative in silico analysis of two vaccine candidates for group A streptococcus predicts that they both may have similar safety profiles

• Main Authors: Melkote S. Shaila, Rabindranath Nayak, Savitha S. Prakash, Melina Georgousakis, Evelyn Brandt, David J. McMillan, Michael R. Batzloff, Sumalee Pruksakorn, Michael F. Good, Kadaba S. Sriprakash
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine; Veterinary
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34147191723&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/60906
• Institution: Chiang Mai University

Background: Concerns of immune cross-reactivity, between epitopes of the group A streptococcal (GAS) M-proteins and host proteins have hindered the progress of an effective GAS vaccine. An ideal M-protein based subunit vaccine should not elicit heart tissue cross-reactive antibody responses and shou...