Incident and prevalent herpes simplex virus type 2 infection increases risk of HIV acquisition among women in Uganda and Zimbabwe

BACKGROUND: An association has been demonstrated between herpes simplex type 2 (HSV-2) and HIV infection among men, but prospective studies in women have yielded mixed results. OBJECTIVE: To estimate the effects of prevalent and incident HSV-2 infection on subsequent HIV acquisition among women in t...

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Main Authors: Joelle M. Brown, Anna Wald, Alan Hubbard, Kittipong Rungruengthanakit, Tsungai Chipato, Sungwal Rugpao, Francis Mmiro, David D. Celentano, Robert S. Salata, Charles S. Morrison, Barbra A. Richardson, Nancy S. Padian
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Published: 2018
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spelling th-cmuir.6653943832-611322018-09-10T04:08:05Z Incident and prevalent herpes simplex virus type 2 infection increases risk of HIV acquisition among women in Uganda and Zimbabwe Joelle M. Brown Anna Wald Alan Hubbard Kittipong Rungruengthanakit Tsungai Chipato Sungwal Rugpao Francis Mmiro David D. Celentano Robert S. Salata Charles S. Morrison Barbra A. Richardson Nancy S. Padian Immunology and Microbiology Medicine BACKGROUND: An association has been demonstrated between herpes simplex type 2 (HSV-2) and HIV infection among men, but prospective studies in women have yielded mixed results. OBJECTIVE: To estimate the effects of prevalent and incident HSV-2 infection on subsequent HIV acquisition among women in two African countries. DESIGN: Prospective cohort study. METHODS: HSV-2 and HIV serostatus were evaluated at enrollment and quarterly for 15-24 months among 4531 sexually active, HIV-uninfected women aged 18-35 years from Uganda and Zimbabwe. The association between prior HSV-2 infection and HIV acquisition was estimated using a marginal structural discrete survival model, adjusted for covariates. RESULTS: HSV-2 seroprevalence at enrollment was 52% in Uganda and 53% in Zimbabwe; seroincidence during follow-up was 9.6 and 8.8/100 person-years in Uganda and Zimbabwe, respectively. In Uganda, the hazard ratio (HR) for HIV was 2.8 [95% confidence interval (CI), 1.5-5.3] among women with seroprevalent HSV-2 and 4.6 (95% CI, 1.6-13.1) among women with seroincident HSV-2, adjusted for confounding. In Zimbabwe, the HR for HIV was 4.4 (95% CI, 2.7-7.2) among women with seroprevalent HSV-2, and 8.6 (95% CI, 4.3-17.1) among women with seroincident HSV-2, adjusted for confounding. The population attributable risk percent for HIV due to prevalent and incident HSV-2 infection was 42% in Uganda and 65% in Zimbabwe. CONCLUSIONS: HSV-2 plays an important role in the acquisition of HIV among women. Efforts to implement known HSV-2 control measures, as well as identify additional measures to control HSV-2, are urgently needed to curb the spread of HIV. © 2007 Lippincott Williams & Wilkins, Inc. 2018-09-10T04:05:14Z 2018-09-10T04:05:14Z 2007-07-01 Journal 02699370 2-s2.0-34447568145 10.1097/QAD.0b013e3282004929 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34447568145&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61132
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Immunology and Microbiology
Medicine
spellingShingle Immunology and Microbiology
Medicine
Joelle M. Brown
Anna Wald
Alan Hubbard
Kittipong Rungruengthanakit
Tsungai Chipato
Sungwal Rugpao
Francis Mmiro
David D. Celentano
Robert S. Salata
Charles S. Morrison
Barbra A. Richardson
Nancy S. Padian
Incident and prevalent herpes simplex virus type 2 infection increases risk of HIV acquisition among women in Uganda and Zimbabwe
description BACKGROUND: An association has been demonstrated between herpes simplex type 2 (HSV-2) and HIV infection among men, but prospective studies in women have yielded mixed results. OBJECTIVE: To estimate the effects of prevalent and incident HSV-2 infection on subsequent HIV acquisition among women in two African countries. DESIGN: Prospective cohort study. METHODS: HSV-2 and HIV serostatus were evaluated at enrollment and quarterly for 15-24 months among 4531 sexually active, HIV-uninfected women aged 18-35 years from Uganda and Zimbabwe. The association between prior HSV-2 infection and HIV acquisition was estimated using a marginal structural discrete survival model, adjusted for covariates. RESULTS: HSV-2 seroprevalence at enrollment was 52% in Uganda and 53% in Zimbabwe; seroincidence during follow-up was 9.6 and 8.8/100 person-years in Uganda and Zimbabwe, respectively. In Uganda, the hazard ratio (HR) for HIV was 2.8 [95% confidence interval (CI), 1.5-5.3] among women with seroprevalent HSV-2 and 4.6 (95% CI, 1.6-13.1) among women with seroincident HSV-2, adjusted for confounding. In Zimbabwe, the HR for HIV was 4.4 (95% CI, 2.7-7.2) among women with seroprevalent HSV-2, and 8.6 (95% CI, 4.3-17.1) among women with seroincident HSV-2, adjusted for confounding. The population attributable risk percent for HIV due to prevalent and incident HSV-2 infection was 42% in Uganda and 65% in Zimbabwe. CONCLUSIONS: HSV-2 plays an important role in the acquisition of HIV among women. Efforts to implement known HSV-2 control measures, as well as identify additional measures to control HSV-2, are urgently needed to curb the spread of HIV. © 2007 Lippincott Williams & Wilkins, Inc.
format Journal
author Joelle M. Brown
Anna Wald
Alan Hubbard
Kittipong Rungruengthanakit
Tsungai Chipato
Sungwal Rugpao
Francis Mmiro
David D. Celentano
Robert S. Salata
Charles S. Morrison
Barbra A. Richardson
Nancy S. Padian
author_facet Joelle M. Brown
Anna Wald
Alan Hubbard
Kittipong Rungruengthanakit
Tsungai Chipato
Sungwal Rugpao
Francis Mmiro
David D. Celentano
Robert S. Salata
Charles S. Morrison
Barbra A. Richardson
Nancy S. Padian
author_sort Joelle M. Brown
title Incident and prevalent herpes simplex virus type 2 infection increases risk of HIV acquisition among women in Uganda and Zimbabwe
title_short Incident and prevalent herpes simplex virus type 2 infection increases risk of HIV acquisition among women in Uganda and Zimbabwe
title_full Incident and prevalent herpes simplex virus type 2 infection increases risk of HIV acquisition among women in Uganda and Zimbabwe
title_fullStr Incident and prevalent herpes simplex virus type 2 infection increases risk of HIV acquisition among women in Uganda and Zimbabwe
title_full_unstemmed Incident and prevalent herpes simplex virus type 2 infection increases risk of HIV acquisition among women in Uganda and Zimbabwe
title_sort incident and prevalent herpes simplex virus type 2 infection increases risk of hiv acquisition among women in uganda and zimbabwe
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34447568145&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/61132
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