A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients

In 9 study centers, 419 patients with asthma or COPD were randomized to receive two forms of salbutamol metered-dose-inhalers (MDIs), i.e. CFC-driven MDI, non-CFC (HFA) MDI and one salbutamol dry powder inhaler (DPI), in a multi-center, comparative, cross-over and randomized study, performed to faci...

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Main Authors: Chaweewan Bunnag, Ratanaporn Fuangtong, Chaicharn Pothirat, Por Punyaratabandhu
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/61135
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-611352018-09-10T04:08:15Z A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients Chaweewan Bunnag Ratanaporn Fuangtong Chaicharn Pothirat Por Punyaratabandhu Immunology and Microbiology Medicine In 9 study centers, 419 patients with asthma or COPD were randomized to receive two forms of salbutamol metered-dose-inhalers (MDIs), i.e. CFC-driven MDI, non-CFC (HFA) MDI and one salbutamol dry powder inhaler (DPI), in a multi-center, comparative, cross-over and randomized study, performed to facilitate the formulation of a strategic plan to phase out CFC MDIs. After having received all three forms of test products, the patients completed an evaluation questionnaire indicating their preferences, likelihood of treatment compliance on each product and the easiest one to use. Statistical analysis showed that the CFC MDI was significantly less irritating (p < 0.014) but lower in its overall appeal (p < 0.0001). The "most preferred form to be prescribed" was DPI at 47.5% followed by non-CFC at 32.5% and CFG MDI at 20.1 %. Concerning the ease of use among the three forms of test products, 59.9% of the patients indicated "no difference". Adverse events were mild and occurred in only 8.2%. In conclusion, patients' preference and sensory perception among the three forms of inhalers were comparable except that the CFC MDI was significantly less irritating but lower in its overall appeal. DPI was the most preferred and easiest form to use but also the most expensive. Taking public health into consideration, a non-CFC MDI with a similar market price to the CFC MDI would be the obvious choice in a strategic plan to phase out CFC MDIs with the least difficulty to the consumers. 2018-09-10T04:05:17Z 2018-09-10T04:05:17Z 2007-06-01 Journal 0125877X 2-s2.0-36049018912 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=36049018912&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61135
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Immunology and Microbiology
Medicine
spellingShingle Immunology and Microbiology
Medicine
Chaweewan Bunnag
Ratanaporn Fuangtong
Chaicharn Pothirat
Por Punyaratabandhu
A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients
description In 9 study centers, 419 patients with asthma or COPD were randomized to receive two forms of salbutamol metered-dose-inhalers (MDIs), i.e. CFC-driven MDI, non-CFC (HFA) MDI and one salbutamol dry powder inhaler (DPI), in a multi-center, comparative, cross-over and randomized study, performed to facilitate the formulation of a strategic plan to phase out CFC MDIs. After having received all three forms of test products, the patients completed an evaluation questionnaire indicating their preferences, likelihood of treatment compliance on each product and the easiest one to use. Statistical analysis showed that the CFC MDI was significantly less irritating (p < 0.014) but lower in its overall appeal (p < 0.0001). The "most preferred form to be prescribed" was DPI at 47.5% followed by non-CFC at 32.5% and CFG MDI at 20.1 %. Concerning the ease of use among the three forms of test products, 59.9% of the patients indicated "no difference". Adverse events were mild and occurred in only 8.2%. In conclusion, patients' preference and sensory perception among the three forms of inhalers were comparable except that the CFC MDI was significantly less irritating but lower in its overall appeal. DPI was the most preferred and easiest form to use but also the most expensive. Taking public health into consideration, a non-CFC MDI with a similar market price to the CFC MDI would be the obvious choice in a strategic plan to phase out CFC MDIs with the least difficulty to the consumers.
format Journal
author Chaweewan Bunnag
Ratanaporn Fuangtong
Chaicharn Pothirat
Por Punyaratabandhu
author_facet Chaweewan Bunnag
Ratanaporn Fuangtong
Chaicharn Pothirat
Por Punyaratabandhu
author_sort Chaweewan Bunnag
title A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients
title_short A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients
title_full A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients
title_fullStr A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients
title_full_unstemmed A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients
title_sort comparative study of patients' preferences and sensory perceptions of three forms of inhalers among thai asthma and copd patients
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=36049018912&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/61135
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