The natural history of HIV-1 subtype e infection in young men in Thailand with up to 14 years of follow-up
OBJECTIVE: We evaluated the progression to AIDS and death among 228 men who seroconverted within a 6-month window when in the Royal Thai Army between 1991 and 1995. DESIGN AND METHODS: Men (N = 228) who seroconverted to HIV at 21-23 years of age between 1991 and 1995 were evaluated up to 14 years af...
Saved in:
Main Authors: | , , , , , |
---|---|
Format: | Journal |
Published: |
2018
|
Subjects: | |
Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=36348985511&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61150 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Chiang Mai University |
id |
th-cmuir.6653943832-61150 |
---|---|
record_format |
dspace |
spelling |
th-cmuir.6653943832-611502018-09-10T04:09:17Z The natural history of HIV-1 subtype e infection in young men in Thailand with up to 14 years of follow-up Ram Rangsin Phunlerd Piyaraj Thira Sirisanthana Narongrid Sirisopana Onsri Short Kenrad E. Nelson Immunology and Microbiology Medicine OBJECTIVE: We evaluated the progression to AIDS and death among 228 men who seroconverted within a 6-month window when in the Royal Thai Army between 1991 and 1995. DESIGN AND METHODS: Men (N = 228) who seroconverted to HIV at 21-23 years of age between 1991 and 1995 were evaluated up to 14 years after HIV seroconversion. The seroconverters were matched with men who were seronegative when they were discharged from the military. In 2005-2006, the vital status was determined through the national mortality database and survivors were contacted for follow-up clinical and immunological assessment. Death certificates, medical records and next of kin interviews were used to evaluate the causes of death. RESULTS: As of March 2006, among 228 seroconverters, 56 (24.6%) were alive, 171 (75.0%) had died and one (0.4%) had undetermined status. Among 255 HIV-seronegative individuals at baseline, 15 (5.9%) had died. The median time from HIV seroconversion to death was 7.8 years. The median time to AIDS death was 8.4 years. The median times from seroconversion to clinical AIDS and a CD4 cell count less than 200 cells/μl were 7.2 years and 6.5 years, respectively. The median time from seroconversion to World Health Organization criteria for antiretroviral therapy was 6.3 years. CONCLUSION: Our data indicate a more rapid progression to AIDS and death after HIV-1 infection among young Thai men than has been reported in similar aged men who were HAART-naive in western high income countries. © 2007 Lippincott Williams & Wilkins, Inc. 2018-09-10T04:05:37Z 2018-09-10T04:05:37Z 2007-01-01 Journal 02699370 2-s2.0-36348985511 10.1097/01.aids.0000299409.29528.23 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=36348985511&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61150 |
institution |
Chiang Mai University |
building |
Chiang Mai University Library |
country |
Thailand |
collection |
CMU Intellectual Repository |
topic |
Immunology and Microbiology Medicine |
spellingShingle |
Immunology and Microbiology Medicine Ram Rangsin Phunlerd Piyaraj Thira Sirisanthana Narongrid Sirisopana Onsri Short Kenrad E. Nelson The natural history of HIV-1 subtype e infection in young men in Thailand with up to 14 years of follow-up |
description |
OBJECTIVE: We evaluated the progression to AIDS and death among 228 men who seroconverted within a 6-month window when in the Royal Thai Army between 1991 and 1995. DESIGN AND METHODS: Men (N = 228) who seroconverted to HIV at 21-23 years of age between 1991 and 1995 were evaluated up to 14 years after HIV seroconversion. The seroconverters were matched with men who were seronegative when they were discharged from the military. In 2005-2006, the vital status was determined through the national mortality database and survivors were contacted for follow-up clinical and immunological assessment. Death certificates, medical records and next of kin interviews were used to evaluate the causes of death. RESULTS: As of March 2006, among 228 seroconverters, 56 (24.6%) were alive, 171 (75.0%) had died and one (0.4%) had undetermined status. Among 255 HIV-seronegative individuals at baseline, 15 (5.9%) had died. The median time from HIV seroconversion to death was 7.8 years. The median time to AIDS death was 8.4 years. The median times from seroconversion to clinical AIDS and a CD4 cell count less than 200 cells/μl were 7.2 years and 6.5 years, respectively. The median time from seroconversion to World Health Organization criteria for antiretroviral therapy was 6.3 years. CONCLUSION: Our data indicate a more rapid progression to AIDS and death after HIV-1 infection among young Thai men than has been reported in similar aged men who were HAART-naive in western high income countries. © 2007 Lippincott Williams & Wilkins, Inc. |
format |
Journal |
author |
Ram Rangsin Phunlerd Piyaraj Thira Sirisanthana Narongrid Sirisopana Onsri Short Kenrad E. Nelson |
author_facet |
Ram Rangsin Phunlerd Piyaraj Thira Sirisanthana Narongrid Sirisopana Onsri Short Kenrad E. Nelson |
author_sort |
Ram Rangsin |
title |
The natural history of HIV-1 subtype e infection in young men in Thailand with up to 14 years of follow-up |
title_short |
The natural history of HIV-1 subtype e infection in young men in Thailand with up to 14 years of follow-up |
title_full |
The natural history of HIV-1 subtype e infection in young men in Thailand with up to 14 years of follow-up |
title_fullStr |
The natural history of HIV-1 subtype e infection in young men in Thailand with up to 14 years of follow-up |
title_full_unstemmed |
The natural history of HIV-1 subtype e infection in young men in Thailand with up to 14 years of follow-up |
title_sort |
natural history of hiv-1 subtype e infection in young men in thailand with up to 14 years of follow-up |
publishDate |
2018 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=36348985511&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61150 |
_version_ |
1681425567168069632 |