Endothelin-1 expression correlates with atypical histological features in mammary phyllodes tumours
Background and Aims: Endothelin-1 expression is increased in infiltrating duct carcinoma and is associated with larger tumour size, higher histological grade and lymphovascular permeation. This has not been evaluated in phyllodes tumours, which are uncommon fibroepithelial lesions with potential for...
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th-cmuir.6653943832-612732018-09-10T04:07:47Z Endothelin-1 expression correlates with atypical histological features in mammary phyllodes tumours Gary M. Tse Benjaporn Chaiwun Kin Mang Lau Richard Scolyer C. Soon Lee Rooshdiya Z. Karim Thomas C. Putti Bonita K. Law Philip C. Lui Puay Hoon Tan Medicine Background and Aims: Endothelin-1 expression is increased in infiltrating duct carcinoma and is associated with larger tumour size, higher histological grade and lymphovascular permeation. This has not been evaluated in phyllodes tumours, which are uncommon fibroepithelial lesions with potential for local recurrences or distant metastasis. While the grading of phyllodes tumours depends on a combination of histological parameters, prediction of their behaviour remains difficult. Method: A large series of 461 phyllodes tumours (291 benign, 115 borderline malignant and 55 frankly malignant) were evaluated for endothelin-1 expression in both the epithelial cells and stromal cells by immunohistochemistry; results were correlated with the tumour grade. Results: For benign phyllodes tumours, the epithelial staining of endothelin was negative, weak, moderate and strong in 6%, 26%, 15% and 53% of cases respectively; results were 4%, 18%, 19% and 59% respectively for borderline and 6%, 18%, 6% and 70% respectively for frankly malignant tumours. For the stromal staining, the negative, weak, moderate and strong staining was 32%, 19%, 18% and 31% respectively for benign phyllodes, 24%, 13%, 10% and 53% respectively for borderline and 8%, 16%, 17% and 59% respectively for frankly malignant tumours. There was correlation between epithelial and stromal staining, and the stromal staining correlated with histological features of stromal cellularity, stromal cell nuclear pleomorphism, margin status and stromal overgrowth. Conclusion: These observations suggest a close relationship between the epithelial and stromal elements in phyllodes tumours; endothelin may play a significant role in the malignant progression of phyllodes tumours. 2018-09-10T04:07:47Z 2018-09-10T04:07:47Z 2007-09-01 Journal 00219746 2-s2.0-34548825657 10.1136/jcp.2006.044354 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34548825657&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61273 |
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Medicine Gary M. Tse Benjaporn Chaiwun Kin Mang Lau Richard Scolyer C. Soon Lee Rooshdiya Z. Karim Thomas C. Putti Bonita K. Law Philip C. Lui Puay Hoon Tan Endothelin-1 expression correlates with atypical histological features in mammary phyllodes tumours |
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Background and Aims: Endothelin-1 expression is increased in infiltrating duct carcinoma and is associated with larger tumour size, higher histological grade and lymphovascular permeation. This has not been evaluated in phyllodes tumours, which are uncommon fibroepithelial lesions with potential for local recurrences or distant metastasis. While the grading of phyllodes tumours depends on a combination of histological parameters, prediction of their behaviour remains difficult. Method: A large series of 461 phyllodes tumours (291 benign, 115 borderline malignant and 55 frankly malignant) were evaluated for endothelin-1 expression in both the epithelial cells and stromal cells by immunohistochemistry; results were correlated with the tumour grade. Results: For benign phyllodes tumours, the epithelial staining of endothelin was negative, weak, moderate and strong in 6%, 26%, 15% and 53% of cases respectively; results were 4%, 18%, 19% and 59% respectively for borderline and 6%, 18%, 6% and 70% respectively for frankly malignant tumours. For the stromal staining, the negative, weak, moderate and strong staining was 32%, 19%, 18% and 31% respectively for benign phyllodes, 24%, 13%, 10% and 53% respectively for borderline and 8%, 16%, 17% and 59% respectively for frankly malignant tumours. There was correlation between epithelial and stromal staining, and the stromal staining correlated with histological features of stromal cellularity, stromal cell nuclear pleomorphism, margin status and stromal overgrowth. Conclusion: These observations suggest a close relationship between the epithelial and stromal elements in phyllodes tumours; endothelin may play a significant role in the malignant progression of phyllodes tumours. |
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Journal |
author |
Gary M. Tse Benjaporn Chaiwun Kin Mang Lau Richard Scolyer C. Soon Lee Rooshdiya Z. Karim Thomas C. Putti Bonita K. Law Philip C. Lui Puay Hoon Tan |
author_facet |
Gary M. Tse Benjaporn Chaiwun Kin Mang Lau Richard Scolyer C. Soon Lee Rooshdiya Z. Karim Thomas C. Putti Bonita K. Law Philip C. Lui Puay Hoon Tan |
author_sort |
Gary M. Tse |
title |
Endothelin-1 expression correlates with atypical histological features in mammary phyllodes tumours |
title_short |
Endothelin-1 expression correlates with atypical histological features in mammary phyllodes tumours |
title_full |
Endothelin-1 expression correlates with atypical histological features in mammary phyllodes tumours |
title_fullStr |
Endothelin-1 expression correlates with atypical histological features in mammary phyllodes tumours |
title_full_unstemmed |
Endothelin-1 expression correlates with atypical histological features in mammary phyllodes tumours |
title_sort |
endothelin-1 expression correlates with atypical histological features in mammary phyllodes tumours |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34548825657&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61273 |
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