Fine-needle aspiration cytology of metaplastic carcinoma of the breast

Background: Metaplastic carcinoma of the breast encompasses a heterogeneous group of tumours with variable components of sarcomatoid, squamous or poorly differentiated carcinomas. Aim: To review a series of 19 cytological preparations of metaplastic carcinomas to assess diagnostic cytological featur...

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Main Authors: Philip C.W. Lui, Gary M.K. Tse, Hoon Tan Puay, Gita Jayaram, Thomas C. Putti, Benjaporn Chaiwun, Norman H.L. Chan, Patrick P.L. Lau, Ling Mak Kong, Aye T. Khin
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Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/61312
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-613122018-09-10T04:08:28Z Fine-needle aspiration cytology of metaplastic carcinoma of the breast Philip C.W. Lui Gary M.K. Tse Hoon Tan Puay Gita Jayaram Thomas C. Putti Benjaporn Chaiwun Norman H.L. Chan Patrick P.L. Lau Ling Mak Kong Aye T. Khin Medicine Background: Metaplastic carcinoma of the breast encompasses a heterogeneous group of tumours with variable components of sarcomatoid, squamous or poorly differentiated carcinomas. Aim: To review a series of 19 cytological preparations of metaplastic carcinomas to assess diagnostic cytological features. Methods: 17 cases of fine-needle aspirates of histologically proven metaplastic carcinomas (4 monophasic spindle cell carcinomas, 4 squamous cell carcinomas and 11 biphasic tumours) were reviewed, with an emphasis on the presence of poorly differentiated carcinoma, squamous cell carcinoma, atypical spindle cells, benign stromal fragments and necrosis. Results: All cases were diagnosed as malignant, with 68% of cases showing moderate to high cellularity, and 47% showing necrosis. If the tumours were analysed according to the constituting components histologically, 7, 15 and 8 cases, respectively, possess poorly differentiated carcinoma cells, sarcomatoid malignant cells and squamous carcinoma cells, whereas these components were cytologically identified in 11, 10 and 7 cases, respectively. Dual tumour populations were identified in only 5 of the 11 biphasic carcinomas in the cytological preparations; and the stromal material was cytologically identified in the only case with chondroid stroma. Conclusions: Identification of metaplastic carcinoma in cytology remains problematic. There seems to be morphological overlap between various components. The identification of dual components, unequivocal squamous carcinoma cells and chondroid stroma is helpful for diagnosis, but it is uncommon. The presence of poorly differentiated carcinoma cells with a suggestion of focal spindle morphology is another clue to the suggestion of metaplastic carcinoma. 2018-09-10T04:08:28Z 2018-09-10T04:08:28Z 2007-05-01 Journal 00219746 2-s2.0-34249882461 10.1136/jcp.2006.039412 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34249882461&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61312
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Philip C.W. Lui
Gary M.K. Tse
Hoon Tan Puay
Gita Jayaram
Thomas C. Putti
Benjaporn Chaiwun
Norman H.L. Chan
Patrick P.L. Lau
Ling Mak Kong
Aye T. Khin
Fine-needle aspiration cytology of metaplastic carcinoma of the breast
description Background: Metaplastic carcinoma of the breast encompasses a heterogeneous group of tumours with variable components of sarcomatoid, squamous or poorly differentiated carcinomas. Aim: To review a series of 19 cytological preparations of metaplastic carcinomas to assess diagnostic cytological features. Methods: 17 cases of fine-needle aspirates of histologically proven metaplastic carcinomas (4 monophasic spindle cell carcinomas, 4 squamous cell carcinomas and 11 biphasic tumours) were reviewed, with an emphasis on the presence of poorly differentiated carcinoma, squamous cell carcinoma, atypical spindle cells, benign stromal fragments and necrosis. Results: All cases were diagnosed as malignant, with 68% of cases showing moderate to high cellularity, and 47% showing necrosis. If the tumours were analysed according to the constituting components histologically, 7, 15 and 8 cases, respectively, possess poorly differentiated carcinoma cells, sarcomatoid malignant cells and squamous carcinoma cells, whereas these components were cytologically identified in 11, 10 and 7 cases, respectively. Dual tumour populations were identified in only 5 of the 11 biphasic carcinomas in the cytological preparations; and the stromal material was cytologically identified in the only case with chondroid stroma. Conclusions: Identification of metaplastic carcinoma in cytology remains problematic. There seems to be morphological overlap between various components. The identification of dual components, unequivocal squamous carcinoma cells and chondroid stroma is helpful for diagnosis, but it is uncommon. The presence of poorly differentiated carcinoma cells with a suggestion of focal spindle morphology is another clue to the suggestion of metaplastic carcinoma.
format Journal
author Philip C.W. Lui
Gary M.K. Tse
Hoon Tan Puay
Gita Jayaram
Thomas C. Putti
Benjaporn Chaiwun
Norman H.L. Chan
Patrick P.L. Lau
Ling Mak Kong
Aye T. Khin
author_facet Philip C.W. Lui
Gary M.K. Tse
Hoon Tan Puay
Gita Jayaram
Thomas C. Putti
Benjaporn Chaiwun
Norman H.L. Chan
Patrick P.L. Lau
Ling Mak Kong
Aye T. Khin
author_sort Philip C.W. Lui
title Fine-needle aspiration cytology of metaplastic carcinoma of the breast
title_short Fine-needle aspiration cytology of metaplastic carcinoma of the breast
title_full Fine-needle aspiration cytology of metaplastic carcinoma of the breast
title_fullStr Fine-needle aspiration cytology of metaplastic carcinoma of the breast
title_full_unstemmed Fine-needle aspiration cytology of metaplastic carcinoma of the breast
title_sort fine-needle aspiration cytology of metaplastic carcinoma of the breast
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34249882461&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/61312
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