Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis

To study the diagnostic significance of antifilarial IgG subclasses in the clinical spectrum of brugian filariasis, IgG1, IgG3 and IgG4 antifilarial antibodies were determined in an exposed population comprising 74 asymptomatic amicrofilaraemics, 30 microfilaraemics, 20 lymphangitis and 16 elephanti...

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Main Authors: S. Wongkamchai, C. Rochjanawatsiriroj, N. Monkong, H. Nochot, S. Loymek, C. Jiraamornnimit, S. Hunnangkul, W. Choochote
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Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/61420
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-614202018-09-11T08:57:36Z Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis S. Wongkamchai C. Rochjanawatsiriroj N. Monkong H. Nochot S. Loymek C. Jiraamornnimit S. Hunnangkul W. Choochote Agricultural and Biological Sciences Immunology and Microbiology To study the diagnostic significance of antifilarial IgG subclasses in the clinical spectrum of brugian filariasis, IgG1, IgG3 and IgG4 antifilarial antibodies were determined in an exposed population comprising 74 asymptomatic amicrofilaraemics, 30 microfilaraemics, 20 lymphangitis and 16 elephantiasis patients resident in Narathiwart province, an area endemic for Brugia malayi lymphatic filariasis in southern Thailand. The dominant isotype of antifilarial antibody was IgG4. A significantly higher percentage of individuals were positive for IgG1 in the microfilaraemic and lymphangitis groups compared with the elephantiasis and endemic normal patients, while a significantly higher positive rate of IgG3 was found in those with lymphangitis. The possible role of these isotypes for diagnostic purposes and the pattern of antibody response in various clinically manifesting groups are discussed. 2018-09-11T08:53:20Z 2018-09-11T08:53:20Z 2006-12-01 Journal 0022149X 2-s2.0-33846488424 10.1017/JOH2006365 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33846488424&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61420
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Agricultural and Biological Sciences
Immunology and Microbiology
spellingShingle Agricultural and Biological Sciences
Immunology and Microbiology
S. Wongkamchai
C. Rochjanawatsiriroj
N. Monkong
H. Nochot
S. Loymek
C. Jiraamornnimit
S. Hunnangkul
W. Choochote
Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis
description To study the diagnostic significance of antifilarial IgG subclasses in the clinical spectrum of brugian filariasis, IgG1, IgG3 and IgG4 antifilarial antibodies were determined in an exposed population comprising 74 asymptomatic amicrofilaraemics, 30 microfilaraemics, 20 lymphangitis and 16 elephantiasis patients resident in Narathiwart province, an area endemic for Brugia malayi lymphatic filariasis in southern Thailand. The dominant isotype of antifilarial antibody was IgG4. A significantly higher percentage of individuals were positive for IgG1 in the microfilaraemic and lymphangitis groups compared with the elephantiasis and endemic normal patients, while a significantly higher positive rate of IgG3 was found in those with lymphangitis. The possible role of these isotypes for diagnostic purposes and the pattern of antibody response in various clinically manifesting groups are discussed.
format Journal
author S. Wongkamchai
C. Rochjanawatsiriroj
N. Monkong
H. Nochot
S. Loymek
C. Jiraamornnimit
S. Hunnangkul
W. Choochote
author_facet S. Wongkamchai
C. Rochjanawatsiriroj
N. Monkong
H. Nochot
S. Loymek
C. Jiraamornnimit
S. Hunnangkul
W. Choochote
author_sort S. Wongkamchai
title Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis
title_short Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis
title_full Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis
title_fullStr Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis
title_full_unstemmed Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis
title_sort diagnostic value of igg isotype responses against brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33846488424&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/61420
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