A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity

A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity

Chromatographic separation of the ethyl acetate extract of roots of Polyalthia cerasoides has led to the isolation of the new compound, 6,8-dihydroxy-7-methoxy-1-methyl-azafluorenone. This compound exhibited potent cytotoxic activities with IC50 values in the range of 2.64-3.58 μg.mL-1 for A549, GLC...

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Main Authors: Pumsalid K., Thaisuchat H., Loetchutinat C., Nuntasaen N., Meepowpan P., Pompimon W.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-78751539201&partnerID=40&md5=fc97eeb1243a923f5f194a419c41c012
http://cmuir.cmu.ac.th/handle/6653943832/6147
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-61472014-08-30T03:23:53Z A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity Pumsalid K. Thaisuchat H. Loetchutinat C. Nuntasaen N. Meepowpan P. Pompimon W. Chromatographic separation of the ethyl acetate extract of roots of Polyalthia cerasoides has led to the isolation of the new compound, 6,8-dihydroxy-7-methoxy-1-methyl-azafluorenone. This compound exhibited potent cytotoxic activities with IC50 values in the range of 2.64-3.58 μg.mL-1 for A549, GLC4 and GLC4/Adr cells, but was not recognized by ABCC1/MRP1 protein. The compound also showed very strong inhibition of M. tuberculosis using a broth microdilution method, with an MIC value of 0.78 μg.mL-1, which was equal to that of ofloxacin, one of the four antibiotic drugs used as a positive control. 2014-08-30T03:23:53Z 2014-08-30T03:23:53Z 2010 Article 1934578X 21299123 http://www.scopus.com/inward/record.url?eid=2-s2.0-78751539201&partnerID=40&md5=fc97eeb1243a923f5f194a419c41c012 http://cmuir.cmu.ac.th/handle/6653943832/6147 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Chromatographic separation of the ethyl acetate extract of roots of Polyalthia cerasoides has led to the isolation of the new compound, 6,8-dihydroxy-7-methoxy-1-methyl-azafluorenone. This compound exhibited potent cytotoxic activities with IC50 values in the range of 2.64-3.58 μg.mL-1 for A549, GLC4 and GLC4/Adr cells, but was not recognized by ABCC1/MRP1 protein. The compound also showed very strong inhibition of M. tuberculosis using a broth microdilution method, with an MIC value of 0.78 μg.mL-1, which was equal to that of ofloxacin, one of the four antibiotic drugs used as a positive control.
format Article
author Pumsalid K.
Thaisuchat H.
Loetchutinat C.
Nuntasaen N.
Meepowpan P.
Pompimon W.
spellingShingle Pumsalid K.
Thaisuchat H.
Loetchutinat C.
Nuntasaen N.
Meepowpan P.
Pompimon W.
A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity
author_facet Pumsalid K.
Thaisuchat H.
Loetchutinat C.
Nuntasaen N.
Meepowpan P.
Pompimon W.
author_sort Pumsalid K.
title A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity
title_short A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity
title_full A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity
title_fullStr A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity
title_full_unstemmed A new azafluorenone from the roots of Polyalthia cerasoides and its biological activity
title_sort new azafluorenone from the roots of polyalthia cerasoides and its biological activity
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-78751539201&partnerID=40&md5=fc97eeb1243a923f5f194a419c41c012
http://cmuir.cmu.ac.th/handle/6653943832/6147
_version_ 1681420559192162304

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