Anti-inflammatory effects of 4-arylcoumarins in LPS-induced murine macrophage RAW 264.7 cells
This research was undertaken to find the in vitro inflammatory action of 5,7-dimethyloxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin produced by Streptomyces aureofaciens CMUAc130. We investigated the effects of 5,7-dimethyloxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylc...
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th-cmuir.6653943832-615052018-09-11T09:01:38Z Anti-inflammatory effects of 4-arylcoumarins in LPS-induced murine macrophage RAW 264.7 cells Thongchai Taechowisan Chunhua Lu Yuemao Shen Saisamorn Lumyong Biochemistry, Genetics and Molecular Biology Medicine Pharmacology, Toxicology and Pharmaceutics This research was undertaken to find the in vitro inflammatory action of 5,7-dimethyloxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin produced by Streptomyces aureofaciens CMUAc130. We investigated the effects of 5,7-dimethyloxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin not only on the formation of NO, prostaglandin E2(PGE2), and tumor necrosis factor-α (TNF-α) but also on inducible nitric oxide synthase and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells. The data obtained were consistent with the modulation of iNOS enzyme expression. A similar fashion was also observed when LPS-induced PGE2release and COX-2 expression were tested. The significant inhibitory effects were shown in concentration-dependent manners. In addition, 5,7-dimethyloxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4- phenylcoumarin also mildly but significantly reduced the formation of TNF-α. These findings support the application of 5,7-dimethyloxy-4-p- methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin as anti-inflammatory agents. © 2006 Informa Healthcare. 2018-09-11T08:54:18Z 2018-09-11T08:54:18Z 2006-10-01 Journal 17445116 13880209 2-s2.0-33750848692 10.1080/13880200600896694 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33750848692&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61505 |
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Biochemistry, Genetics and Molecular Biology Medicine Pharmacology, Toxicology and Pharmaceutics Thongchai Taechowisan Chunhua Lu Yuemao Shen Saisamorn Lumyong Anti-inflammatory effects of 4-arylcoumarins in LPS-induced murine macrophage RAW 264.7 cells |
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This research was undertaken to find the in vitro inflammatory action of 5,7-dimethyloxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin produced by Streptomyces aureofaciens CMUAc130. We investigated the effects of 5,7-dimethyloxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin not only on the formation of NO, prostaglandin E2(PGE2), and tumor necrosis factor-α (TNF-α) but also on inducible nitric oxide synthase and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells. The data obtained were consistent with the modulation of iNOS enzyme expression. A similar fashion was also observed when LPS-induced PGE2release and COX-2 expression were tested. The significant inhibitory effects were shown in concentration-dependent manners. In addition, 5,7-dimethyloxy-4-p-methoxylphenylcoumarin and 5,7-dimethoxy-4- phenylcoumarin also mildly but significantly reduced the formation of TNF-α. These findings support the application of 5,7-dimethyloxy-4-p- methoxylphenylcoumarin and 5,7-dimethoxy-4-phenylcoumarin as anti-inflammatory agents. © 2006 Informa Healthcare. |
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author |
Thongchai Taechowisan Chunhua Lu Yuemao Shen Saisamorn Lumyong |
author_facet |
Thongchai Taechowisan Chunhua Lu Yuemao Shen Saisamorn Lumyong |
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Thongchai Taechowisan |
title |
Anti-inflammatory effects of 4-arylcoumarins in LPS-induced murine macrophage RAW 264.7 cells |
title_short |
Anti-inflammatory effects of 4-arylcoumarins in LPS-induced murine macrophage RAW 264.7 cells |
title_full |
Anti-inflammatory effects of 4-arylcoumarins in LPS-induced murine macrophage RAW 264.7 cells |
title_fullStr |
Anti-inflammatory effects of 4-arylcoumarins in LPS-induced murine macrophage RAW 264.7 cells |
title_full_unstemmed |
Anti-inflammatory effects of 4-arylcoumarins in LPS-induced murine macrophage RAW 264.7 cells |
title_sort |
anti-inflammatory effects of 4-arylcoumarins in lps-induced murine macrophage raw 264.7 cells |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33750848692&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61505 |
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