Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum

Fourteen ferrocenyl aminohydroxynaphthoquinones, analogues of atovaquone, were synthesized from the hydroxynaphthoquinone core. These novel atovaquone derivatives were tested for their in vitro activity against two apicomplexan parasites of medical importance, Toxoplasma gondii and Plasmodium falcip...

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Main Authors:	Apiwat Baramee, Alexandra Coppin, Marlène Mortuaire, Lydie Pelinski, Stanislas Tomavo, Jacques Brocard
Format:	Journal
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=31044441086&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61537
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-61537
record_format	dspace
spelling	th-cmuir.6653943832-615372018-09-11T09:01:44Z Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum Apiwat Baramee Alexandra Coppin Marlène Mortuaire Lydie Pelinski Stanislas Tomavo Jacques Brocard Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Fourteen ferrocenyl aminohydroxynaphthoquinones, analogues of atovaquone, were synthesized from the hydroxynaphthoquinone core. These novel atovaquone derivatives were tested for their in vitro activity against two apicomplexan parasites of medical importance, Toxoplasma gondii and Plasmodium falciparum, including resistant strains to atovaquone (T. gondii) and chloroquine (P. falciparum). Three of these ferrocenic atovaquone derivatives composed of the hydroxynaphthoquinone core plus an amino-ferrocenic group and an aliphatic chain with 6-8 carbon atoms were found to be significantly active against T. gondii. Moreover, these novel compounds were also effective against the atovaquone-resistant strain of T. gondii (AtoR). © 2005 Elsevier Ltd. All rights reserved. 2018-09-11T08:54:43Z 2018-09-11T08:54:43Z 2006-03-01 Journal 09680896 2-s2.0-31044441086 10.1016/j.bmc.2005.09.054 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=31044441086&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61537
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Apiwat Baramee Alexandra Coppin Marlène Mortuaire Lydie Pelinski Stanislas Tomavo Jacques Brocard Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum
description	Fourteen ferrocenyl aminohydroxynaphthoquinones, analogues of atovaquone, were synthesized from the hydroxynaphthoquinone core. These novel atovaquone derivatives were tested for their in vitro activity against two apicomplexan parasites of medical importance, Toxoplasma gondii and Plasmodium falciparum, including resistant strains to atovaquone (T. gondii) and chloroquine (P. falciparum). Three of these ferrocenic atovaquone derivatives composed of the hydroxynaphthoquinone core plus an amino-ferrocenic group and an aliphatic chain with 6-8 carbon atoms were found to be significantly active against T. gondii. Moreover, these novel compounds were also effective against the atovaquone-resistant strain of T. gondii (AtoR). © 2005 Elsevier Ltd. All rights reserved.
format	Journal
author	Apiwat Baramee Alexandra Coppin Marlène Mortuaire Lydie Pelinski Stanislas Tomavo Jacques Brocard
author_facet	Apiwat Baramee Alexandra Coppin Marlène Mortuaire Lydie Pelinski Stanislas Tomavo Jacques Brocard
author_sort	Apiwat Baramee
title	Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum
title_short	Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum
title_full	Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum
title_fullStr	Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum
title_full_unstemmed	Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum
title_sort	synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against toxoplasma gondii and plasmodium falciparum
publishDate	2018
url	https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=31044441086&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61537
_version_	1681425639275495424

Synthesis and in vitro activities of ferrocenic aminohydroxynaphthoquinones against Toxoplasma gondii and Plasmodium falciparum

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