Inhibitory effects of caraway (Carum carvi L.) and its component on N-methyl-N'-nitro-N-nitrosoguanidine-induced mutagenicity

• Main Authors: Masanori Mazaki, Keiko Kataoka, Takemi Kinouchi, Usanee Vinitketkumnuen, Masami Yamada, Takehiko Nohmi, Tomomi Kuwahara, Shigeru Akimoto, Yoshinari Ohnishi
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33645836174&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/61540
• Institution: Chiang Mai University

To elucidate the mechanism of antimutagenicity of caraway, we examined the effects of caraway seed extract on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced mutagenesis in DNA methyltransferase-deficient Salmonella typhimurium strains, O6-methylguanine DNA adduct formation, and thiol conte...