Inhibitory effect of curcumin on WT1 gene expression in patient leukemic cells

• Main Authors: Songyot Anuchapreeda, Pornngarm Limtrakul, Pattra Thanarattanakorn, Somjai Sittipreechacharn, Prasit Chanarat
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33144465710&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/61542
• Institution: Chiang Mai University

Leukemias are common worldwide. Wilms'tumorl (WT1) protein is highly expressed in leukemic blast cells of myeloid and lymphoid origin. Thus, WT1 mRNA serves as a tumor marker for leukemias detection and monitoring disease progression. Curcumin is well known for its anticancer property. The obje...