Clinical outcomes and prognostic factors of node-negative cervical cancer patients with deep stromal invasion or lymphovascular space involvement following radical hysterectomy

Objective: To evaluate the clinical outcomes and prognostic factors of node-negative cervical cancer patients who had deep stromal invasion (DSI) and/or lymphovascular space invasion (LVSI) following radical hysterectomy and pelvic lymphadenectomy (RHPL). Material and Method: The medical records of...

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Main Authors: Prapaporn Suprasert, Jatupol Srisomboon, Sumalee Siriaunkgul, Surapan Khunamornpong, Chailert Phongnarisorn, Sitthicha Siriaree, Kittipat Charoenkwan, Chalong Cheewakriangkrai, Chumnarn Kietpeerakool
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/61811
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-618112018-09-11T08:59:33Z Clinical outcomes and prognostic factors of node-negative cervical cancer patients with deep stromal invasion or lymphovascular space involvement following radical hysterectomy Prapaporn Suprasert Jatupol Srisomboon Sumalee Siriaunkgul Surapan Khunamornpong Chailert Phongnarisorn Sitthicha Siriaree Kittipat Charoenkwan Chalong Cheewakriangkrai Chumnarn Kietpeerakool Medicine Objective: To evaluate the clinical outcomes and prognostic factors of node-negative cervical cancer patients who had deep stromal invasion (DSI) and/or lymphovascular space invasion (LVSI) following radical hysterectomy and pelvic lymphadenectomy (RHPL). Material and Method: The medical records of 150 node-negative stage IA2-IIA cervical cancer patients who had DSI and/or LVSI after RHPL from 1999 to 2004 were reviewed. Results: Eighty-eight (58.4%) patients were treated with RHPL alone. Twenty-eight (18.7%), 23 (15.4%), eight (5.3%), and three (2%) patients received postoperative chemotherapy, chemoradiation, radiotherapy, and brachytherapy, respectively. Overall, 11 (7.3%) patients developed recurrence. The estimated 5- year disease-free survival of the patients was 90.9%. By multivariate analysis, two factors, age of less than 35 years old and a non squamous histology, were significantly independent prognostic. Eight (5.3%) patients experienced treatment-related complications. Conclusion: Node-negative cervical cancer patients with DSI and/or LVSI had excellent clinical outcomes. Young age and non-squamous histology are significant independent prognostic factors. 2018-09-11T08:59:33Z 2018-09-11T08:59:33Z 2006-10-11 Journal 01252208 01252208 2-s2.0-33749437045 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33749437045&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61811
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Prapaporn Suprasert
Jatupol Srisomboon
Sumalee Siriaunkgul
Surapan Khunamornpong
Chailert Phongnarisorn
Sitthicha Siriaree
Kittipat Charoenkwan
Chalong Cheewakriangkrai
Chumnarn Kietpeerakool
Clinical outcomes and prognostic factors of node-negative cervical cancer patients with deep stromal invasion or lymphovascular space involvement following radical hysterectomy
description Objective: To evaluate the clinical outcomes and prognostic factors of node-negative cervical cancer patients who had deep stromal invasion (DSI) and/or lymphovascular space invasion (LVSI) following radical hysterectomy and pelvic lymphadenectomy (RHPL). Material and Method: The medical records of 150 node-negative stage IA2-IIA cervical cancer patients who had DSI and/or LVSI after RHPL from 1999 to 2004 were reviewed. Results: Eighty-eight (58.4%) patients were treated with RHPL alone. Twenty-eight (18.7%), 23 (15.4%), eight (5.3%), and three (2%) patients received postoperative chemotherapy, chemoradiation, radiotherapy, and brachytherapy, respectively. Overall, 11 (7.3%) patients developed recurrence. The estimated 5- year disease-free survival of the patients was 90.9%. By multivariate analysis, two factors, age of less than 35 years old and a non squamous histology, were significantly independent prognostic. Eight (5.3%) patients experienced treatment-related complications. Conclusion: Node-negative cervical cancer patients with DSI and/or LVSI had excellent clinical outcomes. Young age and non-squamous histology are significant independent prognostic factors.
format Journal
author Prapaporn Suprasert
Jatupol Srisomboon
Sumalee Siriaunkgul
Surapan Khunamornpong
Chailert Phongnarisorn
Sitthicha Siriaree
Kittipat Charoenkwan
Chalong Cheewakriangkrai
Chumnarn Kietpeerakool
author_facet Prapaporn Suprasert
Jatupol Srisomboon
Sumalee Siriaunkgul
Surapan Khunamornpong
Chailert Phongnarisorn
Sitthicha Siriaree
Kittipat Charoenkwan
Chalong Cheewakriangkrai
Chumnarn Kietpeerakool
author_sort Prapaporn Suprasert
title Clinical outcomes and prognostic factors of node-negative cervical cancer patients with deep stromal invasion or lymphovascular space involvement following radical hysterectomy
title_short Clinical outcomes and prognostic factors of node-negative cervical cancer patients with deep stromal invasion or lymphovascular space involvement following radical hysterectomy
title_full Clinical outcomes and prognostic factors of node-negative cervical cancer patients with deep stromal invasion or lymphovascular space involvement following radical hysterectomy
title_fullStr Clinical outcomes and prognostic factors of node-negative cervical cancer patients with deep stromal invasion or lymphovascular space involvement following radical hysterectomy
title_full_unstemmed Clinical outcomes and prognostic factors of node-negative cervical cancer patients with deep stromal invasion or lymphovascular space involvement following radical hysterectomy
title_sort clinical outcomes and prognostic factors of node-negative cervical cancer patients with deep stromal invasion or lymphovascular space involvement following radical hysterectomy
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33749437045&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/61811
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