Splenectomy: A strong risk factor for pulmonary hypertension in patients with thalassaemia

Objective: To determine the association between splenectomy and pulmonary hypertension in patients with thalassaemia with anaemia. Design: Prospective cross-sectional study. Methods: 68 patients with thalassaemia, who had a haemoglobin concentration of less than 100 g/l, were recruited into this stu...

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Main Authors: Arintaya Phrommintikul, A. Sukonthasarn, R. Kanjanavanit, W. Nawarawong
Format: Journal
Published: 2018
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spelling th-cmuir.6653943832-618182018-09-11T08:59:37Z Splenectomy: A strong risk factor for pulmonary hypertension in patients with thalassaemia Arintaya Phrommintikul A. Sukonthasarn R. Kanjanavanit W. Nawarawong Medicine Objective: To determine the association between splenectomy and pulmonary hypertension in patients with thalassaemia with anaemia. Design: Prospective cross-sectional study. Methods: 68 patients with thalassaemia, who had a haemoglobin concentration of less than 100 g/l, were recruited into this study. Echocardiography was performed before clinical data were reviewed. Pulmonary artery pressure was estimated by measuring the systolic transtricuspid pressure gradient from tricuspid regurgitation and adding it to the right atrial pressure, which was estimated by the response of the inferior vena cava to inspiration. Pulmonary hypertension was defined as systolic pulmonary artery pressure > 35 mm Hg. History of splenectomy and other clinical data were compared between patients with and without pulmonary hypertension. Results: 29 patients had pulmonary hypertension and 39 did not. Patients with pulmonary hypertension had significantly more nucleated red blood cells and higher platelet counts, and a higher prevalence of splenectomy (75.8% v 25.6%, odds ratio 9.1, 95% confidence interval 3.0 to 27.7). In multivariate analysis, splenectomy was the only factor significantly related to pulmonary hypertension. Conclusion: Splenectomy is a strong risk factor for pulmonary hypertension in patients with thalassaemia. 2018-09-11T08:59:37Z 2018-09-11T08:59:37Z 2006-10-01 Journal 13556037 2-s2.0-33750089012 10.1136/hrt.2005.079970 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33750089012&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61818
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Arintaya Phrommintikul
A. Sukonthasarn
R. Kanjanavanit
W. Nawarawong
Splenectomy: A strong risk factor for pulmonary hypertension in patients with thalassaemia
description Objective: To determine the association between splenectomy and pulmonary hypertension in patients with thalassaemia with anaemia. Design: Prospective cross-sectional study. Methods: 68 patients with thalassaemia, who had a haemoglobin concentration of less than 100 g/l, were recruited into this study. Echocardiography was performed before clinical data were reviewed. Pulmonary artery pressure was estimated by measuring the systolic transtricuspid pressure gradient from tricuspid regurgitation and adding it to the right atrial pressure, which was estimated by the response of the inferior vena cava to inspiration. Pulmonary hypertension was defined as systolic pulmonary artery pressure > 35 mm Hg. History of splenectomy and other clinical data were compared between patients with and without pulmonary hypertension. Results: 29 patients had pulmonary hypertension and 39 did not. Patients with pulmonary hypertension had significantly more nucleated red blood cells and higher platelet counts, and a higher prevalence of splenectomy (75.8% v 25.6%, odds ratio 9.1, 95% confidence interval 3.0 to 27.7). In multivariate analysis, splenectomy was the only factor significantly related to pulmonary hypertension. Conclusion: Splenectomy is a strong risk factor for pulmonary hypertension in patients with thalassaemia.
format Journal
author Arintaya Phrommintikul
A. Sukonthasarn
R. Kanjanavanit
W. Nawarawong
author_facet Arintaya Phrommintikul
A. Sukonthasarn
R. Kanjanavanit
W. Nawarawong
author_sort Arintaya Phrommintikul
title Splenectomy: A strong risk factor for pulmonary hypertension in patients with thalassaemia
title_short Splenectomy: A strong risk factor for pulmonary hypertension in patients with thalassaemia
title_full Splenectomy: A strong risk factor for pulmonary hypertension in patients with thalassaemia
title_fullStr Splenectomy: A strong risk factor for pulmonary hypertension in patients with thalassaemia
title_full_unstemmed Splenectomy: A strong risk factor for pulmonary hypertension in patients with thalassaemia
title_sort splenectomy: a strong risk factor for pulmonary hypertension in patients with thalassaemia
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33750089012&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/61818
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