Metaplastic carcinoma of the breast: A clinicopathological review

Background: Mammary metaplastic carcinoma encompasses epithelial-only carcinoma (high-grade adenosquamous carcinoma or pure squamous cell carcinoma), biphasic epithelial and sarcomatoid carcinoma and monophasic spindle cell carcinoma. Aim: To evaluate the clinicopathological features of a large seri...

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Main Authors: G. M. Tse, P. H. Tan, T. C. Putti, P. C W Lui, B. Chaiwun, B. K B Law
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/61821
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spelling th-cmuir.6653943832-618212018-09-11T08:59:41Z Metaplastic carcinoma of the breast: A clinicopathological review G. M. Tse P. H. Tan T. C. Putti P. C W Lui B. Chaiwun B. K B Law Medicine Background: Mammary metaplastic carcinoma encompasses epithelial-only carcinoma (high-grade adenosquamous carcinoma or pure squamous cell carcinoma), biphasic epithelial and sarcomatoid carcinoma and monophasic spindle cell carcinoma. Aim: To evaluate the clinicopathological features of a large series of 34 metaplastic carcinomas. Methods: 10 epithelial-only, 14 biphasic and 10 monophasic metaplastic carcinomas were assessed for nuclear grade, hormone receptor status, HER2/neu (cerbB2) oncogene expression, Ki-67 and p53, lymph node status and recurrence on follow-up. Results: Intermediate to high nuclear grade were assessed in most (33/34) tumours. Oestrogen and progesterone receptors were negative in 8 of 10 epithelial-only, all 14 biphasic, and 9 of 10 monophasic tumours, cerbB2 was negative in 7 of 10 epithelial-only, all 14 biphasic and 8 of 10 monophasic tumours. Ki-67 was found to be positive in 6 of 10 epithelial-only, 6 of 14 biphasic, and 7 of 10 monophasic tumours, whereas p53 was positive in 6 of 10 epithelial-only, 7 of 14 biphasic, and 8 of 10 monophasic tumours. Lymph node metastases were seen in 7 of 7 epithelial-only, 7 of 11 biphasic, and 3 of 7 monophasic tumours. Recurrences were seen in 4 of 7 epithelial-only, 8 of 9 biphasic, and 4 of 9 monophasic tumours. Conclusions: All three subtypes of metaplastic carcinoma are known to behave aggressively, and should be differentiated from the low-grade fibromatosis-like metaplastic carcinoma, which does not metastasise. Oncological treatment options may be limited by the frequently negative status of hormonal receptor and cerbB2. 2018-09-11T08:59:41Z 2018-09-11T08:59:41Z 2006-10-01 Journal 00219746 2-s2.0-33749996039 10.1136/jcp.2005.030536 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33749996039&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61821
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
G. M. Tse
P. H. Tan
T. C. Putti
P. C W Lui
B. Chaiwun
B. K B Law
Metaplastic carcinoma of the breast: A clinicopathological review
description Background: Mammary metaplastic carcinoma encompasses epithelial-only carcinoma (high-grade adenosquamous carcinoma or pure squamous cell carcinoma), biphasic epithelial and sarcomatoid carcinoma and monophasic spindle cell carcinoma. Aim: To evaluate the clinicopathological features of a large series of 34 metaplastic carcinomas. Methods: 10 epithelial-only, 14 biphasic and 10 monophasic metaplastic carcinomas were assessed for nuclear grade, hormone receptor status, HER2/neu (cerbB2) oncogene expression, Ki-67 and p53, lymph node status and recurrence on follow-up. Results: Intermediate to high nuclear grade were assessed in most (33/34) tumours. Oestrogen and progesterone receptors were negative in 8 of 10 epithelial-only, all 14 biphasic, and 9 of 10 monophasic tumours, cerbB2 was negative in 7 of 10 epithelial-only, all 14 biphasic and 8 of 10 monophasic tumours. Ki-67 was found to be positive in 6 of 10 epithelial-only, 6 of 14 biphasic, and 7 of 10 monophasic tumours, whereas p53 was positive in 6 of 10 epithelial-only, 7 of 14 biphasic, and 8 of 10 monophasic tumours. Lymph node metastases were seen in 7 of 7 epithelial-only, 7 of 11 biphasic, and 3 of 7 monophasic tumours. Recurrences were seen in 4 of 7 epithelial-only, 8 of 9 biphasic, and 4 of 9 monophasic tumours. Conclusions: All three subtypes of metaplastic carcinoma are known to behave aggressively, and should be differentiated from the low-grade fibromatosis-like metaplastic carcinoma, which does not metastasise. Oncological treatment options may be limited by the frequently negative status of hormonal receptor and cerbB2.
format Journal
author G. M. Tse
P. H. Tan
T. C. Putti
P. C W Lui
B. Chaiwun
B. K B Law
author_facet G. M. Tse
P. H. Tan
T. C. Putti
P. C W Lui
B. Chaiwun
B. K B Law
author_sort G. M. Tse
title Metaplastic carcinoma of the breast: A clinicopathological review
title_short Metaplastic carcinoma of the breast: A clinicopathological review
title_full Metaplastic carcinoma of the breast: A clinicopathological review
title_fullStr Metaplastic carcinoma of the breast: A clinicopathological review
title_full_unstemmed Metaplastic carcinoma of the breast: A clinicopathological review
title_sort metaplastic carcinoma of the breast: a clinicopathological review
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33749996039&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/61821
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