Immune reconstitution syndrome after highly active antiretroviral therapy in human immunodeficiency virus-infected Thai children
BACKGROUND: There is little information about the immune reconstitution syndrome (IRS) in children, especially from resource-poor countries. OBJECTIVE: To determine the incidence and spectrum of IRS in advanced stage human immunodeficiency virus (HIV)-infected children after initiation of highly act...
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th-cmuir.6653943832-619182018-09-11T09:01:21Z Immune reconstitution syndrome after highly active antiretroviral therapy in human immunodeficiency virus-infected Thai children Thanyawee Puthanakit Peninnah Oberdorfer Noppadon Akarathum Pornphun Wannarit Thira Sirisanthana Virat Sirisanthana Medicine BACKGROUND: There is little information about the immune reconstitution syndrome (IRS) in children, especially from resource-poor countries. OBJECTIVE: To determine the incidence and spectrum of IRS in advanced stage human immunodeficiency virus (HIV)-infected children after initiation of highly active antiretroviral therapy (HAART). METHODS: Between May 2002 and April 2004, 153 symptomatic HIV-infected children who had CD4 lymphocyte percentage ≤15% initiated HAART in a national antiretroviral drug access program. All patients were followed for 48 weeks. In this study, IRS was defined as a disease event caused by microorganisms or conditions previously reported to be associated with IRS in patients having immunologic and/or virologic response to HAART. RESULTS: The incidence of IRS was 19% (95% confidence interval, 13.1-26.1). The median time of onset was 4 weeks after start of HAART (range, 2-31). There were 32 episodes of IRS, including 14 caused by mycobacterial organisms, 7 by varicella-zoster virus, 7 by herpes simplex virus, 3 by Cryptococcus neoformans and 1 episode of Guillain-Barré syndrome. Patients who had IRS develop had lower baseline CD4 lymphocyte percentages compared with those who did not (P = 0.02). CONCLUSIONS: IRS is common among HIV-infected children who received HAART in their advanced stage of disease. Educational programs for patients and health care workers on recognizing and treating these conditions should be integrated into antiretroviral treatment access programs. Copyright © 2005 by Lippincott Williams & Wilkins. 2018-09-11T09:01:21Z 2018-09-11T09:01:21Z 2006-01-01 Journal 08913668 2-s2.0-33644843752 10.1097/01.inf.0000195618.55453.9a https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33644843752&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61918 |
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Medicine Thanyawee Puthanakit Peninnah Oberdorfer Noppadon Akarathum Pornphun Wannarit Thira Sirisanthana Virat Sirisanthana Immune reconstitution syndrome after highly active antiretroviral therapy in human immunodeficiency virus-infected Thai children |
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BACKGROUND: There is little information about the immune reconstitution syndrome (IRS) in children, especially from resource-poor countries. OBJECTIVE: To determine the incidence and spectrum of IRS in advanced stage human immunodeficiency virus (HIV)-infected children after initiation of highly active antiretroviral therapy (HAART). METHODS: Between May 2002 and April 2004, 153 symptomatic HIV-infected children who had CD4 lymphocyte percentage ≤15% initiated HAART in a national antiretroviral drug access program. All patients were followed for 48 weeks. In this study, IRS was defined as a disease event caused by microorganisms or conditions previously reported to be associated with IRS in patients having immunologic and/or virologic response to HAART. RESULTS: The incidence of IRS was 19% (95% confidence interval, 13.1-26.1). The median time of onset was 4 weeks after start of HAART (range, 2-31). There were 32 episodes of IRS, including 14 caused by mycobacterial organisms, 7 by varicella-zoster virus, 7 by herpes simplex virus, 3 by Cryptococcus neoformans and 1 episode of Guillain-Barré syndrome. Patients who had IRS develop had lower baseline CD4 lymphocyte percentages compared with those who did not (P = 0.02). CONCLUSIONS: IRS is common among HIV-infected children who received HAART in their advanced stage of disease. Educational programs for patients and health care workers on recognizing and treating these conditions should be integrated into antiretroviral treatment access programs. Copyright © 2005 by Lippincott Williams & Wilkins. |
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Thanyawee Puthanakit Peninnah Oberdorfer Noppadon Akarathum Pornphun Wannarit Thira Sirisanthana Virat Sirisanthana |
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Thanyawee Puthanakit Peninnah Oberdorfer Noppadon Akarathum Pornphun Wannarit Thira Sirisanthana Virat Sirisanthana |
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Thanyawee Puthanakit |
title |
Immune reconstitution syndrome after highly active antiretroviral therapy in human immunodeficiency virus-infected Thai children |
title_short |
Immune reconstitution syndrome after highly active antiretroviral therapy in human immunodeficiency virus-infected Thai children |
title_full |
Immune reconstitution syndrome after highly active antiretroviral therapy in human immunodeficiency virus-infected Thai children |
title_fullStr |
Immune reconstitution syndrome after highly active antiretroviral therapy in human immunodeficiency virus-infected Thai children |
title_full_unstemmed |
Immune reconstitution syndrome after highly active antiretroviral therapy in human immunodeficiency virus-infected Thai children |
title_sort |
immune reconstitution syndrome after highly active antiretroviral therapy in human immunodeficiency virus-infected thai children |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33644843752&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61918 |
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