Gestational age determination and prevention of HIV perinatal transmission

Objective: To compare different methods of gestational age (GA) measurement for ensuring effective zidovudine (ZDV) prophylaxis to prevent mother-to-child transmission of HIV. Methods: For 1398 HIV-infected women enrolled in a perinatal prevention trial, gestation durations were calculated based on...

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Main Authors: P. Traisathit, S. Le Cœur, J. Y. Mary, A. Kanjanasing, S. Lamlertkittikul, M. Lallemant
格式: 雜誌
出版: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/61921
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spelling th-cmuir.6653943832-619212018-09-11T09:01:23Z Gestational age determination and prevention of HIV perinatal transmission P. Traisathit S. Le Cœur J. Y. Mary A. Kanjanasing S. Lamlertkittikul M. Lallemant Medicine Objective: To compare different methods of gestational age (GA) measurement for ensuring effective zidovudine (ZDV) prophylaxis to prevent mother-to-child transmission of HIV. Methods: For 1398 HIV-infected women enrolled in a perinatal prevention trial, gestation durations were calculated based on GA estimated using ultrasound (US), date of last menstruation period (LMP), first fundal height (FH1), and a specific algorithm was developed to provide a "reference" GA. The performance of each GA estimate was evaluated by the percentage of women who would have received ≥8 weeks ZDV, if prophylaxis was initiated at 28 weeks. Results: The performances of the algorithm, US, LMP, and FH1were 95.5%, 94.8%, 88.4%, and 83.7%, respectively. US and FH1were significantly better when estimated before and after 24 weeks, respectively. Conclusion: In situations where no US is available and LMP is not or imprecisely known, FH1can be used after 24 weeks to schedule ZDV initiation date. © 2005 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved. 2018-09-11T09:01:23Z 2018-09-11T09:01:23Z 2006-01-01 Journal 00207292 2-s2.0-30744454012 10.1016/j.ijgo.2005.09.021 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=30744454012&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/61921
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
P. Traisathit
S. Le Cœur
J. Y. Mary
A. Kanjanasing
S. Lamlertkittikul
M. Lallemant
Gestational age determination and prevention of HIV perinatal transmission
description Objective: To compare different methods of gestational age (GA) measurement for ensuring effective zidovudine (ZDV) prophylaxis to prevent mother-to-child transmission of HIV. Methods: For 1398 HIV-infected women enrolled in a perinatal prevention trial, gestation durations were calculated based on GA estimated using ultrasound (US), date of last menstruation period (LMP), first fundal height (FH1), and a specific algorithm was developed to provide a "reference" GA. The performance of each GA estimate was evaluated by the percentage of women who would have received ≥8 weeks ZDV, if prophylaxis was initiated at 28 weeks. Results: The performances of the algorithm, US, LMP, and FH1were 95.5%, 94.8%, 88.4%, and 83.7%, respectively. US and FH1were significantly better when estimated before and after 24 weeks, respectively. Conclusion: In situations where no US is available and LMP is not or imprecisely known, FH1can be used after 24 weeks to schedule ZDV initiation date. © 2005 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
format Journal
author P. Traisathit
S. Le Cœur
J. Y. Mary
A. Kanjanasing
S. Lamlertkittikul
M. Lallemant
author_facet P. Traisathit
S. Le Cœur
J. Y. Mary
A. Kanjanasing
S. Lamlertkittikul
M. Lallemant
author_sort P. Traisathit
title Gestational age determination and prevention of HIV perinatal transmission
title_short Gestational age determination and prevention of HIV perinatal transmission
title_full Gestational age determination and prevention of HIV perinatal transmission
title_fullStr Gestational age determination and prevention of HIV perinatal transmission
title_full_unstemmed Gestational age determination and prevention of HIV perinatal transmission
title_sort gestational age determination and prevention of hiv perinatal transmission
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=30744454012&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/61921
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