Gestational age determination and prevention of HIV perinatal transmission

• Main Authors: P. Traisathit, S. Le Cœur, J. Y. Mary, A. Kanjanasing, S. Lamlertkittikul, M. Lallemant
• Format: Journal
• Published: 2018
• Subjects: Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=30744454012&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/61921
• Institution: Chiang Mai University

Objective: To compare different methods of gestational age (GA) measurement for ensuring effective zidovudine (ZDV) prophylaxis to prevent mother-to-child transmission of HIV. Methods: For 1398 HIV-infected women enrolled in a perinatal prevention trial, gestation durations were calculated based on GA estimated using ultrasound (US), date of last menstruation period (LMP), first fundal height (FH1), and a specific algorithm was developed to provide a "reference" GA. The performance of each GA estimate was evaluated by the percentage of women who would have received ≥8 weeks ZDV, if prophylaxis was initiated at 28 weeks. Results: The performances of the algorithm, US, LMP, and FH1were 95.5%, 94.8%, 88.4%, and 83.7%, respectively. US and FH1were significantly better when estimated before and after 24 weeks, respectively. Conclusion: In situations where no US is available and LMP is not or imprecisely known, FH1can be used after 24 weeks to schedule ZDV initiation date. © 2005 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.