Intra-subunit residue interactions from the protein surface to the active site of glutathione S-transferase AdGSTD3-3 impact on structure and enzyme properties

• Main Authors: Jeerang Wongtrakul, Issara Sramala, La Aied Prapanthadara, Albert J. Ketterman
• 格式: 雜誌
• 出版: 2018
• 主題: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• 在線閱讀: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=13444270611&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/62061
• 機構: Chiang Mai University

Structural residues are one of the major factors that modulate the catalytic specificity as well as having a role in stability of the glutathione S-transferases (GST). To understand how residues remote from the active site can affect enzymatic properties, four mutants, His144Ala, Val147Leu, Val147Al...