Synthesis, characterization and melt spinning of a block copolymer of L-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture

This paper describes the synthesis and characterization of a block copolymer of L-lactide (LL) and ε-caprolactone (CL) and its subsequent melt spinning into a monofilament fiber. The synthesis reaction was a two-step process. In the first step, an approximately 50:50 mol% random copolymer, P(LL-co-C...

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Main Authors: Y. Baimark, R. Molloy, N. Molloy, J. Siripitayananon, W. Punyodom, M. Sriyai
Format: Journal
Published: 2018
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spelling th-cmuir.6653943832-620942018-09-11T09:22:18Z Synthesis, characterization and melt spinning of a block copolymer of L-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture Y. Baimark R. Molloy N. Molloy J. Siripitayananon W. Punyodom M. Sriyai Biochemistry, Genetics and Molecular Biology Chemical Engineering This paper describes the synthesis and characterization of a block copolymer of L-lactide (LL) and ε-caprolactone (CL) and its subsequent melt spinning into a monofilament fiber. The synthesis reaction was a two-step process. In the first step, an approximately 50:50 mol% random copolymer, P(LL-co-CL), was synthesized via bulk copolymerization of LL and CL. This first-step prepolymer then became the macroinitiator in the second-step reaction in which more LL monomer was added to form a block copolymer, PLL-b-P(LL-co-CL)-b-PLL. Both the prepolymer and block copolymer were characterized by a combination of analytical techniques comprising dilute-solution viscometry, GPC,1H and13C NMR, DSC and TG. The block copolymer was then processed into a monofilament fiber using a small-scale melt spinning apparatus. The fiber was spun with a minimum amount of chain orientation and crystallinity so that its semi-crystalline morphology could be constructed under more controlled conditions in subsequent off-line hot-drawing and annealing steps. In this way, the fiber's tensile properties and dimensional stability were developed, as indicated by the changes in its stress-strain curve. The final drawn and annealed fiber had a tensile strength (> 400 MPa) approaching that of a commercial PDS II suture of similar size. It is considered that this type of block copolymer has the potential to be developed further as a lower-cost alternative to the current commercial monofilament surgical sutures. © 2005 Springer Science + Business Media, Inc. 2018-09-11T09:21:51Z 2018-09-11T09:21:51Z 2005-08-01 Journal 09574530 2-s2.0-21344448165 10.1007/s10856-005-2605-6 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=21344448165&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62094
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Chemical Engineering
spellingShingle Biochemistry, Genetics and Molecular Biology
Chemical Engineering
Y. Baimark
R. Molloy
N. Molloy
J. Siripitayananon
W. Punyodom
M. Sriyai
Synthesis, characterization and melt spinning of a block copolymer of L-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture
description This paper describes the synthesis and characterization of a block copolymer of L-lactide (LL) and ε-caprolactone (CL) and its subsequent melt spinning into a monofilament fiber. The synthesis reaction was a two-step process. In the first step, an approximately 50:50 mol% random copolymer, P(LL-co-CL), was synthesized via bulk copolymerization of LL and CL. This first-step prepolymer then became the macroinitiator in the second-step reaction in which more LL monomer was added to form a block copolymer, PLL-b-P(LL-co-CL)-b-PLL. Both the prepolymer and block copolymer were characterized by a combination of analytical techniques comprising dilute-solution viscometry, GPC,1H and13C NMR, DSC and TG. The block copolymer was then processed into a monofilament fiber using a small-scale melt spinning apparatus. The fiber was spun with a minimum amount of chain orientation and crystallinity so that its semi-crystalline morphology could be constructed under more controlled conditions in subsequent off-line hot-drawing and annealing steps. In this way, the fiber's tensile properties and dimensional stability were developed, as indicated by the changes in its stress-strain curve. The final drawn and annealed fiber had a tensile strength (> 400 MPa) approaching that of a commercial PDS II suture of similar size. It is considered that this type of block copolymer has the potential to be developed further as a lower-cost alternative to the current commercial monofilament surgical sutures. © 2005 Springer Science + Business Media, Inc.
format Journal
author Y. Baimark
R. Molloy
N. Molloy
J. Siripitayananon
W. Punyodom
M. Sriyai
author_facet Y. Baimark
R. Molloy
N. Molloy
J. Siripitayananon
W. Punyodom
M. Sriyai
author_sort Y. Baimark
title Synthesis, characterization and melt spinning of a block copolymer of L-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture
title_short Synthesis, characterization and melt spinning of a block copolymer of L-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture
title_full Synthesis, characterization and melt spinning of a block copolymer of L-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture
title_fullStr Synthesis, characterization and melt spinning of a block copolymer of L-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture
title_full_unstemmed Synthesis, characterization and melt spinning of a block copolymer of L-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture
title_sort synthesis, characterization and melt spinning of a block copolymer of l-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=21344448165&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/62094
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