Effect of sildenafil citrate on the cardiovascular system
Sildenafil citrate is a drug commonly used to manage erectile dysfunction. It is designated chemically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin- 5-yl)-4 ethoxyphenyl] sulfonyl]-4-methylpiperazine citrate (C22H30N6O4S). It is a highly selective inhibitor of cyclic gua...
Saved in:
Main Authors: | , , |
---|---|
Format: | Journal |
Published: |
2018
|
Subjects: | |
Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=24744445028&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62120 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Chiang Mai University |
id |
th-cmuir.6653943832-62120 |
---|---|
record_format |
dspace |
spelling |
th-cmuir.6653943832-621202018-09-11T09:27:56Z Effect of sildenafil citrate on the cardiovascular system K. Shinlapawittayatorn S. Chattipakorn N. Chattipakorn Biochemistry, Genetics and Molecular Biology Immunology and Microbiology Neuroscience Pharmacology, Toxicology and Pharmaceutics Sildenafil citrate is a drug commonly used to manage erectile dysfunction. It is designated chemically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin- 5-yl)-4 ethoxyphenyl] sulfonyl]-4-methylpiperazine citrate (C22H30N6O4S). It is a highly selective inhibitor of cyclic guanine monophosphate-specific phosphodiesterase type 5. In late March through mid-November 1998, the US Food and Drug Administration (FDA) published a report on 130 confirmed deaths among men (mean age, 64 years) who received prescriptions for sildenafil citrate, a period during which >6 million outpatient prescriptions (representing about 50 million tablets) were dispensed. The US FDA recently reported that significant cardiovascular events, including sudden cardiac death, have occurred in men with erectile dysfunction who were taking sildenafil citrate. These reports have raised concerns that sildenafil citrate may increase the risk of cardiovascular events, particularly fatal arrhythmias, in patients with cardiovascular disease. In the past few years, the cardiac electrophysiological effects of sildenafil citrate have been investigated extensively in both animal and clinical studies. According to extensive data available to date, sildenafil citrate has been shown to pose minimal cardiovascular risks to healthy people taking this drug. Some precautions are needed for patients with cardiovascular diseases. However, the only absolute contraindication for sildenafil citrate is the concurrent use of nitrates. This article is intended to review sildenafil citrate's cardiovascular effects, as well as current debates about its arrhythmogenic effects. 2018-09-11T09:22:07Z 2018-09-11T09:22:07Z 2005-01-01 Journal 0100879X 2-s2.0-24744445028 10.1590/S0100-879X2005000900003 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=24744445028&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62120 |
institution |
Chiang Mai University |
building |
Chiang Mai University Library |
country |
Thailand |
collection |
CMU Intellectual Repository |
topic |
Biochemistry, Genetics and Molecular Biology Immunology and Microbiology Neuroscience Pharmacology, Toxicology and Pharmaceutics |
spellingShingle |
Biochemistry, Genetics and Molecular Biology Immunology and Microbiology Neuroscience Pharmacology, Toxicology and Pharmaceutics K. Shinlapawittayatorn S. Chattipakorn N. Chattipakorn Effect of sildenafil citrate on the cardiovascular system |
description |
Sildenafil citrate is a drug commonly used to manage erectile dysfunction. It is designated chemically as 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin- 5-yl)-4 ethoxyphenyl] sulfonyl]-4-methylpiperazine citrate (C22H30N6O4S). It is a highly selective inhibitor of cyclic guanine monophosphate-specific phosphodiesterase type 5. In late March through mid-November 1998, the US Food and Drug Administration (FDA) published a report on 130 confirmed deaths among men (mean age, 64 years) who received prescriptions for sildenafil citrate, a period during which >6 million outpatient prescriptions (representing about 50 million tablets) were dispensed. The US FDA recently reported that significant cardiovascular events, including sudden cardiac death, have occurred in men with erectile dysfunction who were taking sildenafil citrate. These reports have raised concerns that sildenafil citrate may increase the risk of cardiovascular events, particularly fatal arrhythmias, in patients with cardiovascular disease. In the past few years, the cardiac electrophysiological effects of sildenafil citrate have been investigated extensively in both animal and clinical studies. According to extensive data available to date, sildenafil citrate has been shown to pose minimal cardiovascular risks to healthy people taking this drug. Some precautions are needed for patients with cardiovascular diseases. However, the only absolute contraindication for sildenafil citrate is the concurrent use of nitrates. This article is intended to review sildenafil citrate's cardiovascular effects, as well as current debates about its arrhythmogenic effects. |
format |
Journal |
author |
K. Shinlapawittayatorn S. Chattipakorn N. Chattipakorn |
author_facet |
K. Shinlapawittayatorn S. Chattipakorn N. Chattipakorn |
author_sort |
K. Shinlapawittayatorn |
title |
Effect of sildenafil citrate on the cardiovascular system |
title_short |
Effect of sildenafil citrate on the cardiovascular system |
title_full |
Effect of sildenafil citrate on the cardiovascular system |
title_fullStr |
Effect of sildenafil citrate on the cardiovascular system |
title_full_unstemmed |
Effect of sildenafil citrate on the cardiovascular system |
title_sort |
effect of sildenafil citrate on the cardiovascular system |
publishDate |
2018 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=24744445028&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62120 |
_version_ |
1681425747818840064 |