Radical surgery for T1 and T2 squamous cell carcinoma of the vulva through separate incisions.

OBJECTIVES: The aim of the study was to retrospectively evaluate treatment results in patients with T1 and T2 vulvar carcinoma. MATERIAL AND METHOD: The medical records of 46 patients with T1 and T2 SCC of the vulva undergoing radical excision of the tumor and groin node dissection at Chiang Mai Uni...

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Main Authors: Apichart Khobjai, Jatupol Srisomboon, Kittipat Charoenkwan, Chailert Phongnarisorn, Prapaporn Suprasert, Sitthicha Siriaree, Chalong Cheewakriangkrai, Charuwan Tantipalakorn, Chumnan Kietpeerakool
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Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/62336
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spelling th-cmuir.6653943832-623362018-09-11T09:25:51Z Radical surgery for T1 and T2 squamous cell carcinoma of the vulva through separate incisions. Apichart Khobjai Jatupol Srisomboon Kittipat Charoenkwan Chailert Phongnarisorn Prapaporn Suprasert Sitthicha Siriaree Chalong Cheewakriangkrai Charuwan Tantipalakorn Chumnan Kietpeerakool Medicine OBJECTIVES: The aim of the study was to retrospectively evaluate treatment results in patients with T1 and T2 vulvar carcinoma. MATERIAL AND METHOD: The medical records of 46 patients with T1 and T2 SCC of the vulva undergoing radical excision of the tumor and groin node dissection at Chiang Mai University Hospital between January 1998 and December 2004 were reviewed. The tumor size, histologic grade, nodal status, lymph-vascular space invasion, lesion location, surgical marginal status, complications, recurrence and survival were analyzed. RESULTS: Mean age of the 46 patients (T1 = 15, T2 = 31) was 59 years with a range of 34-84 years. The incidence of lymph node metastases for T1 lesions was 13% compared to 35% for T2 lesions. Twenty nine patients (63%) experienced surgical complications, the most common one was lymphedema (16) while wound breakdown was noted in only 1 patient. With a median follow-up of 15 months, 14 patients (30%) developed recurrence, 3 (20%) and 11 (35%) in patients with T1 and T2 lesions respectively. The overall 5-year disease-free survival and 5-year survival were 37% and 40%, respectively. The 5-year survival of patients with T1 lesion was significantly higher than that of patients with T2 lesion (64% vs 31%, P = 0.04). Patients with negative nodes had significantly better survival than those with positive nodes (56% vs 18%, P = 0.02). In multivariable analysis, only the status of groin node remained as independent prognostic factors for survival. CONCLUSION: Radical excision and groin node dissection through separate incision for T1 and T2 squamous cell carcinoma of the vulva in this study has a less favorable survival outcome compared with the literature. 2018-09-11T09:25:51Z 2018-09-11T09:25:51Z 2005-10-01 Journal 01252208 2-s2.0-34848894302 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34848894302&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62336
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Apichart Khobjai
Jatupol Srisomboon
Kittipat Charoenkwan
Chailert Phongnarisorn
Prapaporn Suprasert
Sitthicha Siriaree
Chalong Cheewakriangkrai
Charuwan Tantipalakorn
Chumnan Kietpeerakool
Radical surgery for T1 and T2 squamous cell carcinoma of the vulva through separate incisions.
description OBJECTIVES: The aim of the study was to retrospectively evaluate treatment results in patients with T1 and T2 vulvar carcinoma. MATERIAL AND METHOD: The medical records of 46 patients with T1 and T2 SCC of the vulva undergoing radical excision of the tumor and groin node dissection at Chiang Mai University Hospital between January 1998 and December 2004 were reviewed. The tumor size, histologic grade, nodal status, lymph-vascular space invasion, lesion location, surgical marginal status, complications, recurrence and survival were analyzed. RESULTS: Mean age of the 46 patients (T1 = 15, T2 = 31) was 59 years with a range of 34-84 years. The incidence of lymph node metastases for T1 lesions was 13% compared to 35% for T2 lesions. Twenty nine patients (63%) experienced surgical complications, the most common one was lymphedema (16) while wound breakdown was noted in only 1 patient. With a median follow-up of 15 months, 14 patients (30%) developed recurrence, 3 (20%) and 11 (35%) in patients with T1 and T2 lesions respectively. The overall 5-year disease-free survival and 5-year survival were 37% and 40%, respectively. The 5-year survival of patients with T1 lesion was significantly higher than that of patients with T2 lesion (64% vs 31%, P = 0.04). Patients with negative nodes had significantly better survival than those with positive nodes (56% vs 18%, P = 0.02). In multivariable analysis, only the status of groin node remained as independent prognostic factors for survival. CONCLUSION: Radical excision and groin node dissection through separate incision for T1 and T2 squamous cell carcinoma of the vulva in this study has a less favorable survival outcome compared with the literature.
format Journal
author Apichart Khobjai
Jatupol Srisomboon
Kittipat Charoenkwan
Chailert Phongnarisorn
Prapaporn Suprasert
Sitthicha Siriaree
Chalong Cheewakriangkrai
Charuwan Tantipalakorn
Chumnan Kietpeerakool
author_facet Apichart Khobjai
Jatupol Srisomboon
Kittipat Charoenkwan
Chailert Phongnarisorn
Prapaporn Suprasert
Sitthicha Siriaree
Chalong Cheewakriangkrai
Charuwan Tantipalakorn
Chumnan Kietpeerakool
author_sort Apichart Khobjai
title Radical surgery for T1 and T2 squamous cell carcinoma of the vulva through separate incisions.
title_short Radical surgery for T1 and T2 squamous cell carcinoma of the vulva through separate incisions.
title_full Radical surgery for T1 and T2 squamous cell carcinoma of the vulva through separate incisions.
title_fullStr Radical surgery for T1 and T2 squamous cell carcinoma of the vulva through separate incisions.
title_full_unstemmed Radical surgery for T1 and T2 squamous cell carcinoma of the vulva through separate incisions.
title_sort radical surgery for t1 and t2 squamous cell carcinoma of the vulva through separate incisions.
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34848894302&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/62336
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