Clear-cell adenocarcinoma of the female genital tract: Presence of hyaline stroma and tigroid background in various types of cytologic specimens

Hyaline basement membrane-like stromal material and tigroid background are distinctive cytologic features observed in Diff-Quik (DQ)- or Giemsa-stained smears of clear-cell adenocarcinoma (CCA) of the female genital tract. However, it is uncertain how often these features are present in different ty...

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Main Authors: Surapan Khunamornpong, Paul S. Thorner, Prapaporn Suprasert, Sumalee Siriaunkgul
Format: Journal
Published: 2018
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-623912018-09-11T09:26:34Z Clear-cell adenocarcinoma of the female genital tract: Presence of hyaline stroma and tigroid background in various types of cytologic specimens Surapan Khunamornpong Paul S. Thorner Prapaporn Suprasert Sumalee Siriaunkgul Medicine Hyaline basement membrane-like stromal material and tigroid background are distinctive cytologic features observed in Diff-Quik (DQ)- or Giemsa-stained smears of clear-cell adenocarcinoma (CCA) of the female genital tract. However, it is uncertain how often these features are present in different types of cytologic specimens, and which type of preparation is optimal for this diagnosis. We therefore reviewed the cytologic features of CCA in three types of specimens, including 15 scrape cytology specimens, 7 fine-needle aspiration (FNA) specimens, and 15 peritoneal cytology specimens, with emphasis on the features observed in DQ-stained smears. The cell morphology in scrape cytology specimens and FNA specimens was comparable, whereas in peritoneal cytology specimens, the cytoplasm was better preserved. Most tumor cells had fragile cytoplasm containing variable amounts of fine vacuoles, and round nuclei with distinct or prominent nucleoli. Hyaline stroma was present in 93% of scrape cytology specimens, 71% of FNA specimens, and 80% of peritoneal cytology specimens. Tigroid background was observed in 47% of scrape cytology specimens, 43% of FNA specimens, but in none of the peritoneal cytology specimens. Formation of a tigroid background may be prevented by the abundant fluid content in peritoneal cytology specimens. Hyaline stroma and tigroid background were uncommonly seen in scrape smears from other types of primary ovarian tumors, mainly juvenile granulosa cell tumor and yolk sac tumor. However, the additional presence of papillary structures allows CCA to be readily distinguished from these other tumors. We propose that scrape cytology offers the best approach for the intraoperative cytologic diagnosis of CCA. Diagn. © 2005 Wiley-Liss, Inc. 2018-09-11T09:26:34Z 2018-09-11T09:26:34Z 2005-06-01 Journal 87551039 2-s2.0-19544384402 10.1002/dc.20257 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=19544384402&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62391
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Surapan Khunamornpong
Paul S. Thorner
Prapaporn Suprasert
Sumalee Siriaunkgul
Clear-cell adenocarcinoma of the female genital tract: Presence of hyaline stroma and tigroid background in various types of cytologic specimens
description Hyaline basement membrane-like stromal material and tigroid background are distinctive cytologic features observed in Diff-Quik (DQ)- or Giemsa-stained smears of clear-cell adenocarcinoma (CCA) of the female genital tract. However, it is uncertain how often these features are present in different types of cytologic specimens, and which type of preparation is optimal for this diagnosis. We therefore reviewed the cytologic features of CCA in three types of specimens, including 15 scrape cytology specimens, 7 fine-needle aspiration (FNA) specimens, and 15 peritoneal cytology specimens, with emphasis on the features observed in DQ-stained smears. The cell morphology in scrape cytology specimens and FNA specimens was comparable, whereas in peritoneal cytology specimens, the cytoplasm was better preserved. Most tumor cells had fragile cytoplasm containing variable amounts of fine vacuoles, and round nuclei with distinct or prominent nucleoli. Hyaline stroma was present in 93% of scrape cytology specimens, 71% of FNA specimens, and 80% of peritoneal cytology specimens. Tigroid background was observed in 47% of scrape cytology specimens, 43% of FNA specimens, but in none of the peritoneal cytology specimens. Formation of a tigroid background may be prevented by the abundant fluid content in peritoneal cytology specimens. Hyaline stroma and tigroid background were uncommonly seen in scrape smears from other types of primary ovarian tumors, mainly juvenile granulosa cell tumor and yolk sac tumor. However, the additional presence of papillary structures allows CCA to be readily distinguished from these other tumors. We propose that scrape cytology offers the best approach for the intraoperative cytologic diagnosis of CCA. Diagn. © 2005 Wiley-Liss, Inc.
format Journal
author Surapan Khunamornpong
Paul S. Thorner
Prapaporn Suprasert
Sumalee Siriaunkgul
author_facet Surapan Khunamornpong
Paul S. Thorner
Prapaporn Suprasert
Sumalee Siriaunkgul
author_sort Surapan Khunamornpong
title Clear-cell adenocarcinoma of the female genital tract: Presence of hyaline stroma and tigroid background in various types of cytologic specimens
title_short Clear-cell adenocarcinoma of the female genital tract: Presence of hyaline stroma and tigroid background in various types of cytologic specimens
title_full Clear-cell adenocarcinoma of the female genital tract: Presence of hyaline stroma and tigroid background in various types of cytologic specimens
title_fullStr Clear-cell adenocarcinoma of the female genital tract: Presence of hyaline stroma and tigroid background in various types of cytologic specimens
title_full_unstemmed Clear-cell adenocarcinoma of the female genital tract: Presence of hyaline stroma and tigroid background in various types of cytologic specimens
title_sort clear-cell adenocarcinoma of the female genital tract: presence of hyaline stroma and tigroid background in various types of cytologic specimens
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=19544384402&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/62391
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