Anti-gastric ulcer effect of Kaempferia parviflora

Kaempferia parviflora is a Zingiberaceous plant, which has been reputed for its beneficial medicinal effects. The present study was undertaken to evaluate the Kaempferia parviflora ethanolic extract (KPE) for its anti-gastric ulcer activity by experimental models. Oral administration of the KPE at 3...

Full description

Saved in:
Bibliographic Details
Main Authors: C. Rujjanawate, D. Kanjanapothi, D. Amornlerdpison, S. Pojanagaroon
Format: Journal
Published: 2018
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=25444454612&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/62458
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-62458
record_format dspace
spelling th-cmuir.6653943832-624582018-09-11T09:27:45Z Anti-gastric ulcer effect of Kaempferia parviflora C. Rujjanawate D. Kanjanapothi D. Amornlerdpison S. Pojanagaroon Pharmacology, Toxicology and Pharmaceutics Kaempferia parviflora is a Zingiberaceous plant, which has been reputed for its beneficial medicinal effects. The present study was undertaken to evaluate the Kaempferia parviflora ethanolic extract (KPE) for its anti-gastric ulcer activity by experimental models. Oral administration of the KPE at 30, 60 and 120 mg/kg significantly inhibited gastric ulcer formation induced by indomethacin, HCl/EtOH and water immersion restraint-stress in rats. In pylorus-ligated rats, pretreatment with the KPE had no effect on gastric volume, pH and acidity output. In ethanol-induced ulcerated rats, gastric wall mucus was significantly preserved by the KPE pretreatment at doses of 60 and 120 but not at 30 mg/kg. The findings indicate that the ethanolic extract of Kaempferia parviflora possesses gastroprotective potential which is related partly to preservation of gastric mucus secretion and unrelated to the inhibition of gastric acid secretion. © 2005 Elsevier Ireland Ltd. All rights reserved. 2018-09-11T09:27:45Z 2018-09-11T09:27:45Z 2005-10-31 Journal 03788741 2-s2.0-25444454612 10.1016/j.jep.2005.03.035 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=25444454612&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62458
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Pharmacology, Toxicology and Pharmaceutics
spellingShingle Pharmacology, Toxicology and Pharmaceutics
C. Rujjanawate
D. Kanjanapothi
D. Amornlerdpison
S. Pojanagaroon
Anti-gastric ulcer effect of Kaempferia parviflora
description Kaempferia parviflora is a Zingiberaceous plant, which has been reputed for its beneficial medicinal effects. The present study was undertaken to evaluate the Kaempferia parviflora ethanolic extract (KPE) for its anti-gastric ulcer activity by experimental models. Oral administration of the KPE at 30, 60 and 120 mg/kg significantly inhibited gastric ulcer formation induced by indomethacin, HCl/EtOH and water immersion restraint-stress in rats. In pylorus-ligated rats, pretreatment with the KPE had no effect on gastric volume, pH and acidity output. In ethanol-induced ulcerated rats, gastric wall mucus was significantly preserved by the KPE pretreatment at doses of 60 and 120 but not at 30 mg/kg. The findings indicate that the ethanolic extract of Kaempferia parviflora possesses gastroprotective potential which is related partly to preservation of gastric mucus secretion and unrelated to the inhibition of gastric acid secretion. © 2005 Elsevier Ireland Ltd. All rights reserved.
format Journal
author C. Rujjanawate
D. Kanjanapothi
D. Amornlerdpison
S. Pojanagaroon
author_facet C. Rujjanawate
D. Kanjanapothi
D. Amornlerdpison
S. Pojanagaroon
author_sort C. Rujjanawate
title Anti-gastric ulcer effect of Kaempferia parviflora
title_short Anti-gastric ulcer effect of Kaempferia parviflora
title_full Anti-gastric ulcer effect of Kaempferia parviflora
title_fullStr Anti-gastric ulcer effect of Kaempferia parviflora
title_full_unstemmed Anti-gastric ulcer effect of Kaempferia parviflora
title_sort anti-gastric ulcer effect of kaempferia parviflora
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=25444454612&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/62458
_version_ 1681425810696699904