Potential roles of neurotensin on cognition in conditions of obese-insulin resistance

© 2018 Elsevier Ltd Neurotensin is an endogenous tridecapeptide that can be found in both central and peripheral nervous systems. Under normal physiological conditions, neurotensin is involved in the regulation of pain, body temperature, physical activity, appetite as well as learning and memory. In...

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Main Authors: Napatsorn Saiyasit, Jirapas Sripetchwandee, Nipon Chattipakorn, Siriporn C. Chattipakorn
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/62551
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-625512018-11-29T07:55:02Z Potential roles of neurotensin on cognition in conditions of obese-insulin resistance Napatsorn Saiyasit Jirapas Sripetchwandee Nipon Chattipakorn Siriporn C. Chattipakorn Biochemistry, Genetics and Molecular Biology Neuroscience © 2018 Elsevier Ltd Neurotensin is an endogenous tridecapeptide that can be found in both central and peripheral nervous systems. Under normal physiological conditions, neurotensin is involved in the regulation of pain, body temperature, physical activity, appetite as well as learning and memory. In addition, it plays an important role in fat metabolism. Previous studies have demonstrated that alterations of neurotensin levels were associated with several neuropathological conditions such as Alzheimer's disease, mood disorders, and obesity associated eating disorders. Obesity has been shown to be associated with low-grade systemic inflammation, brain inflammation, and cognitive decline. Several pieces of evidence suggest that neurotensin might play a role in cognitive decline following obesity. However, the underlying mechanisms of neurotensin on cognition under obese-insulin resistant condition are still unclear. In this review, the current available evidence from in vitro, in vivo and clinical studies regarding the role of neurotensin in the physiological condition and obesity in association with cognition are comprehensively summarized and discussed. The studies which report controversial findings regarding these issues are also presented and discussed. 2018-11-29T07:32:11Z 2018-11-29T07:32:11Z 2018-12-01 Journal 15322785 01434179 2-s2.0-85054048952 10.1016/j.npep.2018.09.002 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85054048952&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62551
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Neuroscience
spellingShingle Biochemistry, Genetics and Molecular Biology
Neuroscience
Napatsorn Saiyasit
Jirapas Sripetchwandee
Nipon Chattipakorn
Siriporn C. Chattipakorn
Potential roles of neurotensin on cognition in conditions of obese-insulin resistance
description © 2018 Elsevier Ltd Neurotensin is an endogenous tridecapeptide that can be found in both central and peripheral nervous systems. Under normal physiological conditions, neurotensin is involved in the regulation of pain, body temperature, physical activity, appetite as well as learning and memory. In addition, it plays an important role in fat metabolism. Previous studies have demonstrated that alterations of neurotensin levels were associated with several neuropathological conditions such as Alzheimer's disease, mood disorders, and obesity associated eating disorders. Obesity has been shown to be associated with low-grade systemic inflammation, brain inflammation, and cognitive decline. Several pieces of evidence suggest that neurotensin might play a role in cognitive decline following obesity. However, the underlying mechanisms of neurotensin on cognition under obese-insulin resistant condition are still unclear. In this review, the current available evidence from in vitro, in vivo and clinical studies regarding the role of neurotensin in the physiological condition and obesity in association with cognition are comprehensively summarized and discussed. The studies which report controversial findings regarding these issues are also presented and discussed.
format Journal
author Napatsorn Saiyasit
Jirapas Sripetchwandee
Nipon Chattipakorn
Siriporn C. Chattipakorn
author_facet Napatsorn Saiyasit
Jirapas Sripetchwandee
Nipon Chattipakorn
Siriporn C. Chattipakorn
author_sort Napatsorn Saiyasit
title Potential roles of neurotensin on cognition in conditions of obese-insulin resistance
title_short Potential roles of neurotensin on cognition in conditions of obese-insulin resistance
title_full Potential roles of neurotensin on cognition in conditions of obese-insulin resistance
title_fullStr Potential roles of neurotensin on cognition in conditions of obese-insulin resistance
title_full_unstemmed Potential roles of neurotensin on cognition in conditions of obese-insulin resistance
title_sort potential roles of neurotensin on cognition in conditions of obese-insulin resistance
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85054048952&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/62551
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