Modulated expression of the HIV-1 2LTR zinc finger efficiently interferes with the HIV integration process

• Main Authors: Sutpirat Moonmuang, Somphot Saoin, Koollawat Chupradit, Supachai Sakkhachornphop, Nipan Israsena, Ruttachuk Rungsiwiwut, Chatchai Tayapiwatana
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85052957177&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/62563
• Institution: Chiang Mai University

© 2018 The Author(s). Lentiviral vectors have emerged as the most efficient system to stably transfer and insert genes into cells. By adding a tetracycline (Tet)-inducible promoter, transgene expression delivered by a lentiviral vector can be expressed whenever needed and halted when necessary. Here...