Effects of Circumpapillary Retinal Nerve Fiber Layer Segmentation Error Correction on Glaucoma Diagnosis in Myopic Eyes

© Copyright 2018 Wolters Kluwer Health, Inc. All rights reserved. Purpose: In a myopic population, we investigated the occurrence of circumpapillary retinal nerve fiber layer (RNFL) segmentation errors that required manual correction in optical coherence tomography (OCT) and its effect on glaucoma d...

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Main Authors: Yanin Suwan, Samantha Rettig, Sung Chul Park, Apichat Tantraworasin, Lawrence S. Geyman, Keith Effert, Luis Silva, Ravivarn Jarukasetphorn, Robert Ritch
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/62784
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-627842018-11-29T07:50:10Z Effects of Circumpapillary Retinal Nerve Fiber Layer Segmentation Error Correction on Glaucoma Diagnosis in Myopic Eyes Yanin Suwan Samantha Rettig Sung Chul Park Apichat Tantraworasin Lawrence S. Geyman Keith Effert Luis Silva Ravivarn Jarukasetphorn Robert Ritch Medicine © Copyright 2018 Wolters Kluwer Health, Inc. All rights reserved. Purpose: In a myopic population, we investigated the occurrence of circumpapillary retinal nerve fiber layer (RNFL) segmentation errors that required manual correction in optical coherence tomography (OCT) and its effect on glaucoma diagnostic capability of OCT. Materials and Methods: Myopic subjects (spherical equivalent refractive error <-3 D) with and without primary open-angle glaucoma were recruited. Three circumpapillary RNFL scans with diameters of 3.45, 4.50, and 6.00 mm were obtained using spectral-domain OCT. RNFL segmentation errors were manually corrected. Receiver operating characteristic curves of retinal nerve fiber layer thickness (RNFLT) were obtained and area under the curves were calculated before and after manual correction. Results: In total, 90 myopic eyes with glaucoma (90 patients; visual field mean deviation, -9.5±7.1 dB) and 58 myopic eyes without glaucoma (58 control subjects) were included. Glaucomatous eyes required manual correction more frequently than control eyes (56% vs. 32% of RNFL OCT scans; P<0.001). After manual correction in the glaucoma group, the global RNFLT decreased significantly from 61.8 to 57.5 μm (P=0.025), 50.8 to 47.2 μm (P=0.019), and 45.5 to 39.6 μm (P=0.006) for the 3.45-, 4.50-, and 6.00-mm scans, respectively. After manual correction of RNFL segmentation errors, the glaucoma diagnostic capability of the global RNFLT improved significantly; the area under the curves increased from 0.827 to 0.886 (P=0.017), 0.829 to 0.880 (P=0.033), and 0.762 to 0.846 (P=0.006) for the 3.45-, 4.50-, and 6.00-mm scans, respectively. Conclusions: A significant proportion of myopic eyes had RNFL segmentation errors in automated spectral-domain OCT analysis, decreasing glaucoma diagnostic capability of OCT RNFLT measurement. 2018-11-29T07:50:10Z 2018-11-29T07:50:10Z 2018-11-01 Journal 1536481X 10570829 2-s2.0-85052822533 10.1097/IJG.0000000000001054 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85052822533&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62784
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Yanin Suwan
Samantha Rettig
Sung Chul Park
Apichat Tantraworasin
Lawrence S. Geyman
Keith Effert
Luis Silva
Ravivarn Jarukasetphorn
Robert Ritch
Effects of Circumpapillary Retinal Nerve Fiber Layer Segmentation Error Correction on Glaucoma Diagnosis in Myopic Eyes
description © Copyright 2018 Wolters Kluwer Health, Inc. All rights reserved. Purpose: In a myopic population, we investigated the occurrence of circumpapillary retinal nerve fiber layer (RNFL) segmentation errors that required manual correction in optical coherence tomography (OCT) and its effect on glaucoma diagnostic capability of OCT. Materials and Methods: Myopic subjects (spherical equivalent refractive error <-3 D) with and without primary open-angle glaucoma were recruited. Three circumpapillary RNFL scans with diameters of 3.45, 4.50, and 6.00 mm were obtained using spectral-domain OCT. RNFL segmentation errors were manually corrected. Receiver operating characteristic curves of retinal nerve fiber layer thickness (RNFLT) were obtained and area under the curves were calculated before and after manual correction. Results: In total, 90 myopic eyes with glaucoma (90 patients; visual field mean deviation, -9.5±7.1 dB) and 58 myopic eyes without glaucoma (58 control subjects) were included. Glaucomatous eyes required manual correction more frequently than control eyes (56% vs. 32% of RNFL OCT scans; P<0.001). After manual correction in the glaucoma group, the global RNFLT decreased significantly from 61.8 to 57.5 μm (P=0.025), 50.8 to 47.2 μm (P=0.019), and 45.5 to 39.6 μm (P=0.006) for the 3.45-, 4.50-, and 6.00-mm scans, respectively. After manual correction of RNFL segmentation errors, the glaucoma diagnostic capability of the global RNFLT improved significantly; the area under the curves increased from 0.827 to 0.886 (P=0.017), 0.829 to 0.880 (P=0.033), and 0.762 to 0.846 (P=0.006) for the 3.45-, 4.50-, and 6.00-mm scans, respectively. Conclusions: A significant proportion of myopic eyes had RNFL segmentation errors in automated spectral-domain OCT analysis, decreasing glaucoma diagnostic capability of OCT RNFLT measurement.
format Journal
author Yanin Suwan
Samantha Rettig
Sung Chul Park
Apichat Tantraworasin
Lawrence S. Geyman
Keith Effert
Luis Silva
Ravivarn Jarukasetphorn
Robert Ritch
author_facet Yanin Suwan
Samantha Rettig
Sung Chul Park
Apichat Tantraworasin
Lawrence S. Geyman
Keith Effert
Luis Silva
Ravivarn Jarukasetphorn
Robert Ritch
author_sort Yanin Suwan
title Effects of Circumpapillary Retinal Nerve Fiber Layer Segmentation Error Correction on Glaucoma Diagnosis in Myopic Eyes
title_short Effects of Circumpapillary Retinal Nerve Fiber Layer Segmentation Error Correction on Glaucoma Diagnosis in Myopic Eyes
title_full Effects of Circumpapillary Retinal Nerve Fiber Layer Segmentation Error Correction on Glaucoma Diagnosis in Myopic Eyes
title_fullStr Effects of Circumpapillary Retinal Nerve Fiber Layer Segmentation Error Correction on Glaucoma Diagnosis in Myopic Eyes
title_full_unstemmed Effects of Circumpapillary Retinal Nerve Fiber Layer Segmentation Error Correction on Glaucoma Diagnosis in Myopic Eyes
title_sort effects of circumpapillary retinal nerve fiber layer segmentation error correction on glaucoma diagnosis in myopic eyes
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85052822533&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/62784
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