Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Coix lacryma-jobi Linn.) Fractions

Liposomes, entrapped with Job's Tears fractions, were prepared by the supercritical carbon dioxide fluid (scCO₂) technique with and without sonication. Physical characteristics, which were the particle size, zeta potential, vesicular morphology, microviscosity and bioactivities including anti-p...

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Main Authors: Aranya Manosroi, Mathukorn Sainakham, Masahiko Abe, Kenichi Sakai, Nuttanan Sinchaipanid, Worapaka Manosroi, Jiradej Manosroi
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/62931
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-629312018-12-14T03:41:39Z Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Coix lacryma-jobi Linn.) Fractions Aranya Manosroi Mathukorn Sainakham Masahiko Abe Kenichi Sakai Nuttanan Sinchaipanid Worapaka Manosroi Jiradej Manosroi Medicine Liposomes, entrapped with Job's Tears fractions, were prepared by the supercritical carbon dioxide fluid (scCO₂) technique with and without sonication. Physical characteristics, which were the particle size, zeta potential, vesicular morphology, microviscosity and bioactivities including anti-proliferative, apoptotic and antioxidative activities of the S1L-S5L liposomal systems, were investigated. The potent anti-proliferative activity with the IC50 value of 4.44±2.31 ug/ml in a colon cancer cell (HT-29) was observed in the S5L. S5L also showed the apoptotic activity of 4.45±0.92% in an HT-29 cell. For antioxidative activities, the S3L showed the highest free radical scavenging activity and lipid peroxidation inhibition, whereas the S4L gave the highest metal chelating activity. This study has demonstrated the potent anti-proliferative activity on an HT-29 cell of the S5L liposomal formulation prepared by the scCO₂ technique which can be further developed towards a novel anticancer drug. 2018-12-14T03:41:39Z 2018-12-14T03:41:39Z 2019-04-01 Journal 15334880 2-s2.0-85057558965 10.1166/jnn.2019.15802 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85057558965&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62931
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Aranya Manosroi
Mathukorn Sainakham
Masahiko Abe
Kenichi Sakai
Nuttanan Sinchaipanid
Worapaka Manosroi
Jiradej Manosroi
Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Coix lacryma-jobi Linn.) Fractions
description Liposomes, entrapped with Job's Tears fractions, were prepared by the supercritical carbon dioxide fluid (scCO₂) technique with and without sonication. Physical characteristics, which were the particle size, zeta potential, vesicular morphology, microviscosity and bioactivities including anti-proliferative, apoptotic and antioxidative activities of the S1L-S5L liposomal systems, were investigated. The potent anti-proliferative activity with the IC50 value of 4.44±2.31 ug/ml in a colon cancer cell (HT-29) was observed in the S5L. S5L also showed the apoptotic activity of 4.45±0.92% in an HT-29 cell. For antioxidative activities, the S3L showed the highest free radical scavenging activity and lipid peroxidation inhibition, whereas the S4L gave the highest metal chelating activity. This study has demonstrated the potent anti-proliferative activity on an HT-29 cell of the S5L liposomal formulation prepared by the scCO₂ technique which can be further developed towards a novel anticancer drug.
format Journal
author Aranya Manosroi
Mathukorn Sainakham
Masahiko Abe
Kenichi Sakai
Nuttanan Sinchaipanid
Worapaka Manosroi
Jiradej Manosroi
author_facet Aranya Manosroi
Mathukorn Sainakham
Masahiko Abe
Kenichi Sakai
Nuttanan Sinchaipanid
Worapaka Manosroi
Jiradej Manosroi
author_sort Aranya Manosroi
title Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Coix lacryma-jobi Linn.) Fractions
title_short Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Coix lacryma-jobi Linn.) Fractions
title_full Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Coix lacryma-jobi Linn.) Fractions
title_fullStr Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Coix lacryma-jobi Linn.) Fractions
title_full_unstemmed Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Coix lacryma-jobi Linn.) Fractions
title_sort potent anti-proliferation on the colon cancer cell line (ht-29) of liposomal formulations entrapped with semi-purified job's tears (coix lacryma-jobi linn.) fractions
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85057558965&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/62931
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