Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Coix lacryma-jobi Linn.) Fractions
Liposomes, entrapped with Job's Tears fractions, were prepared by the supercritical carbon dioxide fluid (scCO₂) technique with and without sonication. Physical characteristics, which were the particle size, zeta potential, vesicular morphology, microviscosity and bioactivities including anti-p...
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th-cmuir.6653943832-629312018-12-14T03:41:39Z Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Coix lacryma-jobi Linn.) Fractions Aranya Manosroi Mathukorn Sainakham Masahiko Abe Kenichi Sakai Nuttanan Sinchaipanid Worapaka Manosroi Jiradej Manosroi Medicine Liposomes, entrapped with Job's Tears fractions, were prepared by the supercritical carbon dioxide fluid (scCO₂) technique with and without sonication. Physical characteristics, which were the particle size, zeta potential, vesicular morphology, microviscosity and bioactivities including anti-proliferative, apoptotic and antioxidative activities of the S1L-S5L liposomal systems, were investigated. The potent anti-proliferative activity with the IC50 value of 4.44±2.31 ug/ml in a colon cancer cell (HT-29) was observed in the S5L. S5L also showed the apoptotic activity of 4.45±0.92% in an HT-29 cell. For antioxidative activities, the S3L showed the highest free radical scavenging activity and lipid peroxidation inhibition, whereas the S4L gave the highest metal chelating activity. This study has demonstrated the potent anti-proliferative activity on an HT-29 cell of the S5L liposomal formulation prepared by the scCO₂ technique which can be further developed towards a novel anticancer drug. 2018-12-14T03:41:39Z 2018-12-14T03:41:39Z 2019-04-01 Journal 15334880 2-s2.0-85057558965 10.1166/jnn.2019.15802 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85057558965&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62931 |
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Medicine Aranya Manosroi Mathukorn Sainakham Masahiko Abe Kenichi Sakai Nuttanan Sinchaipanid Worapaka Manosroi Jiradej Manosroi Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Coix lacryma-jobi Linn.) Fractions |
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Liposomes, entrapped with Job's Tears fractions, were prepared by the supercritical carbon dioxide fluid (scCO₂) technique with and without sonication. Physical characteristics, which were the particle size, zeta potential, vesicular morphology, microviscosity and bioactivities including anti-proliferative, apoptotic and antioxidative activities of the S1L-S5L liposomal systems, were investigated. The potent anti-proliferative activity with the IC50 value of 4.44±2.31 ug/ml in a colon cancer cell (HT-29) was observed in the S5L. S5L also showed the apoptotic activity of 4.45±0.92% in an HT-29 cell. For antioxidative activities, the S3L showed the highest free radical scavenging activity and lipid peroxidation inhibition, whereas the S4L gave the highest metal chelating activity. This study has demonstrated the potent anti-proliferative activity on an HT-29 cell of the S5L liposomal formulation prepared by the scCO₂ technique which can be further developed towards a novel anticancer drug. |
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Aranya Manosroi Mathukorn Sainakham Masahiko Abe Kenichi Sakai Nuttanan Sinchaipanid Worapaka Manosroi Jiradej Manosroi |
author_facet |
Aranya Manosroi Mathukorn Sainakham Masahiko Abe Kenichi Sakai Nuttanan Sinchaipanid Worapaka Manosroi Jiradej Manosroi |
author_sort |
Aranya Manosroi |
title |
Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Coix lacryma-jobi Linn.) Fractions |
title_short |
Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Coix lacryma-jobi Linn.) Fractions |
title_full |
Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Coix lacryma-jobi Linn.) Fractions |
title_fullStr |
Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Coix lacryma-jobi Linn.) Fractions |
title_full_unstemmed |
Potent Anti-Proliferation on the Colon Cancer Cell Line (HT-29) of Liposomal Formulations Entrapped with Semi-Purified Job's Tears (Coix lacryma-jobi Linn.) Fractions |
title_sort |
potent anti-proliferation on the colon cancer cell line (ht-29) of liposomal formulations entrapped with semi-purified job's tears (coix lacryma-jobi linn.) fractions |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85057558965&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/62931 |
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1681425898044129280 |