Oblongolides from the endophytic fungus Phomopsis sp. BCC 9789
Six new oblongolides, W1, W2, X, Y, and Z (1-3, 6, 7) and 2-deoxy-4α-hydroxyoblongolide X (4), and the known compounds oblongolide (8), oblongolides T, C, and Q (5, 9, 10), and (-)-5-methylmellein were isolated from the endophytic fungus Phomopsis sp. BCC 9789. Compound 7 showed anti-HSV-1 activity...
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2014
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th-cmuir.6653943832-63632014-08-30T03:24:08Z Oblongolides from the endophytic fungus Phomopsis sp. BCC 9789 Bunyapaiboonsri T. Yoiprommarat S. Srikitikulchai P. Srichomthong K. Lumyong S. Six new oblongolides, W1, W2, X, Y, and Z (1-3, 6, 7) and 2-deoxy-4α-hydroxyoblongolide X (4), and the known compounds oblongolide (8), oblongolides T, C, and Q (5, 9, 10), and (-)-5-methylmellein were isolated from the endophytic fungus Phomopsis sp. BCC 9789. Compound 7 showed anti-HSV-1 activity (IC50 ) 14 μM) and cytotoxic activities against KB, BC, NCI-H187, and nonmalignant (Vero) cell lines with respective IC50 values of 37, 26, 32, and 60 μM. Cytotoxic activity against the BC cell line was also observed for compound 6, with an IC50 value of 48 μM. © 2010 American Chemical Society and American Society of Pharmacognosy. 2014-08-30T03:24:08Z 2014-08-30T03:24:08Z 2010 Article 1633864 10.1021/np900650c 20038128 JNPRD http://www.scopus.com/inward/record.url?eid=2-s2.0-76049090657&partnerID=40&md5=ac22e188ad5b5d0ffbca76c7d743651e http://cmuir.cmu.ac.th/handle/6653943832/6363 English |
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Chiang Mai University |
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Chiang Mai University Library |
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Thailand |
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| language |
English |
| description |
Six new oblongolides, W1, W2, X, Y, and Z (1-3, 6, 7) and 2-deoxy-4α-hydroxyoblongolide X (4), and the known compounds oblongolide (8), oblongolides T, C, and Q (5, 9, 10), and (-)-5-methylmellein were isolated from the endophytic fungus Phomopsis sp. BCC 9789. Compound 7 showed anti-HSV-1 activity (IC50 ) 14 μM) and cytotoxic activities against KB, BC, NCI-H187, and nonmalignant (Vero) cell lines with respective IC50 values of 37, 26, 32, and 60 μM. Cytotoxic activity against the BC cell line was also observed for compound 6, with an IC50 value of 48 μM. © 2010 American Chemical Society and American Society of Pharmacognosy. |
| format |
Article |
| author |
Bunyapaiboonsri T. Yoiprommarat S. Srikitikulchai P. Srichomthong K. Lumyong S. |
| spellingShingle |
Bunyapaiboonsri T. Yoiprommarat S. Srikitikulchai P. Srichomthong K. Lumyong S. Oblongolides from the endophytic fungus Phomopsis sp. BCC 9789 |
| author_facet |
Bunyapaiboonsri T. Yoiprommarat S. Srikitikulchai P. Srichomthong K. Lumyong S. |
| author_sort |
Bunyapaiboonsri T. |
| title |
Oblongolides from the endophytic fungus Phomopsis sp. BCC 9789 |
| title_short |
Oblongolides from the endophytic fungus Phomopsis sp. BCC 9789 |
| title_full |
Oblongolides from the endophytic fungus Phomopsis sp. BCC 9789 |
| title_fullStr |
Oblongolides from the endophytic fungus Phomopsis sp. BCC 9789 |
| title_full_unstemmed |
Oblongolides from the endophytic fungus Phomopsis sp. BCC 9789 |
| title_sort |
oblongolides from the endophytic fungus phomopsis sp. bcc 9789 |
| publishDate |
2014 |
| url |
http://www.scopus.com/inward/record.url?eid=2-s2.0-76049090657&partnerID=40&md5=ac22e188ad5b5d0ffbca76c7d743651e http://cmuir.cmu.ac.th/handle/6653943832/6363 |
| _version_ |
1681420599854891008 |