The Longitudinal Effects of Non-injection Substance Use on Sustained HIV Viral Load Undetectability Among MSM and Heterosexual Men in Brazil and Thailand: The Role of ART Adherence and Depressive Symptoms (HPTN 063)

© 2019, Springer Science+Business Media, LLC, part of Springer Nature. The effect of non-injection substance use on HIV viral load (VL) is understudied in international settings. Data are from HPTN063, a longitudinal observational study of HIV-infected individuals in Brazil, Thailand, and Zambia, wi...

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Main Authors: Kiyomi Tsuyuki, Steven J. Shoptaw, Yusuf Ransome, Gordon Chau, Carlos E. Rodriguez-Diaz, Ruth K. Friedman, Kriengkrai Srithanaviboonchai, Sue Li, Matthew J. Mimiaga, Kenneth H. Mayer, Steven A. Safren
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Published: 2019
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/63694
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-636942019-03-18T02:25:59Z The Longitudinal Effects of Non-injection Substance Use on Sustained HIV Viral Load Undetectability Among MSM and Heterosexual Men in Brazil and Thailand: The Role of ART Adherence and Depressive Symptoms (HPTN 063) Kiyomi Tsuyuki Steven J. Shoptaw Yusuf Ransome Gordon Chau Carlos E. Rodriguez-Diaz Ruth K. Friedman Kriengkrai Srithanaviboonchai Sue Li Matthew J. Mimiaga Kenneth H. Mayer Steven A. Safren Medicine Psychology © 2019, Springer Science+Business Media, LLC, part of Springer Nature. The effect of non-injection substance use on HIV viral load (VL) is understudied in international settings. Data are from HPTN063, a longitudinal observational study of HIV-infected individuals in Brazil, Thailand, and Zambia, with focus on men with VL data (Brazil = 146; Thailand = 159). Generalized linear mixed models (GLMM) assessed whether non-injection substance use (stimulants, cannabis, alcohol, polysubstance) was associated with VL undetectability. ART adherence and depressive symptoms were examined as mediators of the association. In Thailand, substance use was not significantly associated with VL undetectability or ART adherence, but alcohol misuse among MSM was associated with increased odds of depression (AOR = 2.75; 95% CI 1.20, 6.32, p = 0.02). In Brazil, alcohol misuse by MSM was associated with decreased odds of undetectable VL (AOR = 0.34; 95% CI 0.13, 0.92, p = 0.03). Polysubstance use by heterosexual men in Brazil was associated with decreased odds of ART adherence (AOR = 0.25; 95% CI 0.08, 0.78, p = 0.02). VL suppression appears attainable among non-injection substance users. Substance use interventions among HIV-positive men should address depression, adherence, and VL undetectability. 2019-03-18T02:24:13Z 2019-03-18T02:24:13Z 2019-03-15 Journal 15733254 10907165 2-s2.0-85061262298 10.1007/s10461-019-02415-w https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85061262298&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/63694
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
Psychology
spellingShingle Medicine
Psychology
Kiyomi Tsuyuki
Steven J. Shoptaw
Yusuf Ransome
Gordon Chau
Carlos E. Rodriguez-Diaz
Ruth K. Friedman
Kriengkrai Srithanaviboonchai
Sue Li
Matthew J. Mimiaga
Kenneth H. Mayer
Steven A. Safren
The Longitudinal Effects of Non-injection Substance Use on Sustained HIV Viral Load Undetectability Among MSM and Heterosexual Men in Brazil and Thailand: The Role of ART Adherence and Depressive Symptoms (HPTN 063)
description © 2019, Springer Science+Business Media, LLC, part of Springer Nature. The effect of non-injection substance use on HIV viral load (VL) is understudied in international settings. Data are from HPTN063, a longitudinal observational study of HIV-infected individuals in Brazil, Thailand, and Zambia, with focus on men with VL data (Brazil = 146; Thailand = 159). Generalized linear mixed models (GLMM) assessed whether non-injection substance use (stimulants, cannabis, alcohol, polysubstance) was associated with VL undetectability. ART adherence and depressive symptoms were examined as mediators of the association. In Thailand, substance use was not significantly associated with VL undetectability or ART adherence, but alcohol misuse among MSM was associated with increased odds of depression (AOR = 2.75; 95% CI 1.20, 6.32, p = 0.02). In Brazil, alcohol misuse by MSM was associated with decreased odds of undetectable VL (AOR = 0.34; 95% CI 0.13, 0.92, p = 0.03). Polysubstance use by heterosexual men in Brazil was associated with decreased odds of ART adherence (AOR = 0.25; 95% CI 0.08, 0.78, p = 0.02). VL suppression appears attainable among non-injection substance users. Substance use interventions among HIV-positive men should address depression, adherence, and VL undetectability.
format Journal
author Kiyomi Tsuyuki
Steven J. Shoptaw
Yusuf Ransome
Gordon Chau
Carlos E. Rodriguez-Diaz
Ruth K. Friedman
Kriengkrai Srithanaviboonchai
Sue Li
Matthew J. Mimiaga
Kenneth H. Mayer
Steven A. Safren
author_facet Kiyomi Tsuyuki
Steven J. Shoptaw
Yusuf Ransome
Gordon Chau
Carlos E. Rodriguez-Diaz
Ruth K. Friedman
Kriengkrai Srithanaviboonchai
Sue Li
Matthew J. Mimiaga
Kenneth H. Mayer
Steven A. Safren
author_sort Kiyomi Tsuyuki
title The Longitudinal Effects of Non-injection Substance Use on Sustained HIV Viral Load Undetectability Among MSM and Heterosexual Men in Brazil and Thailand: The Role of ART Adherence and Depressive Symptoms (HPTN 063)
title_short The Longitudinal Effects of Non-injection Substance Use on Sustained HIV Viral Load Undetectability Among MSM and Heterosexual Men in Brazil and Thailand: The Role of ART Adherence and Depressive Symptoms (HPTN 063)
title_full The Longitudinal Effects of Non-injection Substance Use on Sustained HIV Viral Load Undetectability Among MSM and Heterosexual Men in Brazil and Thailand: The Role of ART Adherence and Depressive Symptoms (HPTN 063)
title_fullStr The Longitudinal Effects of Non-injection Substance Use on Sustained HIV Viral Load Undetectability Among MSM and Heterosexual Men in Brazil and Thailand: The Role of ART Adherence and Depressive Symptoms (HPTN 063)
title_full_unstemmed The Longitudinal Effects of Non-injection Substance Use on Sustained HIV Viral Load Undetectability Among MSM and Heterosexual Men in Brazil and Thailand: The Role of ART Adherence and Depressive Symptoms (HPTN 063)
title_sort longitudinal effects of non-injection substance use on sustained hiv viral load undetectability among msm and heterosexual men in brazil and thailand: the role of art adherence and depressive symptoms (hptn 063)
publishDate 2019
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85061262298&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/63694
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