Prevalence of pretreatment HIV drug resistance in West African and Southeast Asian countries

© The Author(s) 2018. Background ART in the developing world has moved to a new era with the WHO recommendation to test and immediately treat HIV-positive individuals. A high frequency of pretreatment HIV drug resistance (PDR) can compromise ART efficacy. Our study presents updated estimates of PDR...

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Main Authors: Nicole Ngo-Giang-Huong, Thu H.K. Huynh, Anoumou Y. Dagnra, Thomas D.Aquin Toni, Almoustapha I. Maiga, Dramane Kania, Sabrina Eymard-Duvernay, Martine Peeters, Cathia Soulie, Gilles Peytavin, Claire Rekacewicz, Marie Laure Chaix, Avelin F. Aghokeng
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Published: 2019
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/63713
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-637132019-03-18T02:25:31Z Prevalence of pretreatment HIV drug resistance in West African and Southeast Asian countries Nicole Ngo-Giang-Huong Thu H.K. Huynh Anoumou Y. Dagnra Thomas D.Aquin Toni Almoustapha I. Maiga Dramane Kania Sabrina Eymard-Duvernay Martine Peeters Cathia Soulie Gilles Peytavin Claire Rekacewicz Marie Laure Chaix Avelin F. Aghokeng Medicine Pharmacology, Toxicology and Pharmaceutics © The Author(s) 2018. Background ART in the developing world has moved to a new era with the WHO recommendation to test and immediately treat HIV-positive individuals. A high frequency of pretreatment HIV drug resistance (PDR) can compromise ART efficacy. Our study presents updated estimates of PDR in seven countries from West Africa (Burkina Faso, Cameroon, Côte d'Ivoire, Mali and Togo) and Southeast Asia (Thailand and Vietnam). Methods Eligible study participants were adult ART initiators, recruited from December 2015 to November 2016 in major ART clinics in each country. HIV drug resistance (HIVDR) tests were performed for all specimens and interpretation was done using the Stanford algorithm. Results Overall, 1153 participants were recruited and 1020 nt sequences were generated. PDR frequency among all initiators was 15.9% (95% CI: 13.8%-18.3%) overall, ranging from 9.6% and 10.2% in Burkina Faso and Thailand, respectively, 14.7% in Vietnam, 15.4% in Mali, 16.5% in Côte d'Ivoire and 19.3% in Cameroon, to 24.6% in Togo. The prevalence of NNRTI resistance mutations was 12%; NRTI and PI PDR prevalences were 4% and 3%, respectively. Conclusions Our study shows that in most countries PDR exceeded 10%, warranting the conduct of nationally representative surveys to confirm this trend. In the meantime, actions to prevent drug resistance, including transition from NNRTIs to more robust drug classes should be urgently implemented. 2019-03-18T02:24:37Z 2019-03-18T02:24:37Z 2019-02-01 Journal 14602091 03057453 2-s2.0-85060139226 10.1093/jac/dky443 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85060139226&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/63713
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Medicine
Pharmacology, Toxicology and Pharmaceutics
Nicole Ngo-Giang-Huong
Thu H.K. Huynh
Anoumou Y. Dagnra
Thomas D.Aquin Toni
Almoustapha I. Maiga
Dramane Kania
Sabrina Eymard-Duvernay
Martine Peeters
Cathia Soulie
Gilles Peytavin
Claire Rekacewicz
Marie Laure Chaix
Avelin F. Aghokeng
Prevalence of pretreatment HIV drug resistance in West African and Southeast Asian countries
description © The Author(s) 2018. Background ART in the developing world has moved to a new era with the WHO recommendation to test and immediately treat HIV-positive individuals. A high frequency of pretreatment HIV drug resistance (PDR) can compromise ART efficacy. Our study presents updated estimates of PDR in seven countries from West Africa (Burkina Faso, Cameroon, Côte d'Ivoire, Mali and Togo) and Southeast Asia (Thailand and Vietnam). Methods Eligible study participants were adult ART initiators, recruited from December 2015 to November 2016 in major ART clinics in each country. HIV drug resistance (HIVDR) tests were performed for all specimens and interpretation was done using the Stanford algorithm. Results Overall, 1153 participants were recruited and 1020 nt sequences were generated. PDR frequency among all initiators was 15.9% (95% CI: 13.8%-18.3%) overall, ranging from 9.6% and 10.2% in Burkina Faso and Thailand, respectively, 14.7% in Vietnam, 15.4% in Mali, 16.5% in Côte d'Ivoire and 19.3% in Cameroon, to 24.6% in Togo. The prevalence of NNRTI resistance mutations was 12%; NRTI and PI PDR prevalences were 4% and 3%, respectively. Conclusions Our study shows that in most countries PDR exceeded 10%, warranting the conduct of nationally representative surveys to confirm this trend. In the meantime, actions to prevent drug resistance, including transition from NNRTIs to more robust drug classes should be urgently implemented.
format Journal
author Nicole Ngo-Giang-Huong
Thu H.K. Huynh
Anoumou Y. Dagnra
Thomas D.Aquin Toni
Almoustapha I. Maiga
Dramane Kania
Sabrina Eymard-Duvernay
Martine Peeters
Cathia Soulie
Gilles Peytavin
Claire Rekacewicz
Marie Laure Chaix
Avelin F. Aghokeng
author_facet Nicole Ngo-Giang-Huong
Thu H.K. Huynh
Anoumou Y. Dagnra
Thomas D.Aquin Toni
Almoustapha I. Maiga
Dramane Kania
Sabrina Eymard-Duvernay
Martine Peeters
Cathia Soulie
Gilles Peytavin
Claire Rekacewicz
Marie Laure Chaix
Avelin F. Aghokeng
author_sort Nicole Ngo-Giang-Huong
title Prevalence of pretreatment HIV drug resistance in West African and Southeast Asian countries
title_short Prevalence of pretreatment HIV drug resistance in West African and Southeast Asian countries
title_full Prevalence of pretreatment HIV drug resistance in West African and Southeast Asian countries
title_fullStr Prevalence of pretreatment HIV drug resistance in West African and Southeast Asian countries
title_full_unstemmed Prevalence of pretreatment HIV drug resistance in West African and Southeast Asian countries
title_sort prevalence of pretreatment hiv drug resistance in west african and southeast asian countries
publishDate 2019
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85060139226&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/63713
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