Biogenic synthesis of silver palladium bimetallic nanoparticles from fruit extract of Terminalia chebula – In vitro evaluation of anticancer and antimicrobial activity

© 2019 Elsevier B.V. Biogenic synthesis of nanoparticles used for biomedical application has received much attention nowadays owing to its quick synthesis, cost effectiveness and biocompatible nature. The present study focuses on the biosynthesis of silver palladium bimetallic nanoparticles (AgPd NP...

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Main Authors: Bhagavathi Sundaram Sivamaruthi, Vijayan Sri Ramkumar, Govindaraju Archunan, Chaiyavat Chaiyasut, Natarajan Suganthy
Format: Journal
Published: 2019
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/63752
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-637522019-03-18T02:25:29Z Biogenic synthesis of silver palladium bimetallic nanoparticles from fruit extract of Terminalia chebula – In vitro evaluation of anticancer and antimicrobial activity Bhagavathi Sundaram Sivamaruthi Vijayan Sri Ramkumar Govindaraju Archunan Chaiyavat Chaiyasut Natarajan Suganthy Pharmacology, Toxicology and Pharmaceutics © 2019 Elsevier B.V. Biogenic synthesis of nanoparticles used for biomedical application has received much attention nowadays owing to its quick synthesis, cost effectiveness and biocompatible nature. The present study focuses on the biosynthesis of silver palladium bimetallic nanoparticles (AgPd NPs) from aqueous fruit extract of Terminalia chebula. Synthesized AgPd NP was assessed for antimicrobial activity and anticancer potential against lung cancer cells (A549). XRD analysis confirmed the formation of face centered cubic crystalline structure with average size of 20 nm, which was affirmed by DLS analysis. Uniform spherical shaped nanoparticles were observed in SEM and TEM analysis. Zeta potential value of −14.4 mV illustrated the stability of AgPd NPs. Anticancer studies illustrated that AgPd NPs induced ROS generation in lung cancer cells, thereby stimulating mitochondrial apoptotic pathway causing cell death. AgPd NPs exhibited antimicrobial activity against methicillin resistant Staphylococcus aureus and Pseudomonas aeruginosa. In vitro toxicity studies revealed that AgPd NPs exhibited no cyototoxic and hemolytic effect upto its maximum dose (200 μg/ml), ensuring the biocompatibility of nanoparticles. Our findings demonstrated that aqueous extract of T. chebula act as effective reducing and stabilizing agent for green synthesis of biocompatible AgPd NPs, which exhibits potent antimicrobial and anticancer activities. 2019-03-18T02:25:29Z 2019-03-18T02:25:29Z 2019-06-01 Journal 17732247 2-s2.0-85062542057 10.1016/j.jddst.2019.02.024 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85062542057&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/63752
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Pharmacology, Toxicology and Pharmaceutics
spellingShingle Pharmacology, Toxicology and Pharmaceutics
Bhagavathi Sundaram Sivamaruthi
Vijayan Sri Ramkumar
Govindaraju Archunan
Chaiyavat Chaiyasut
Natarajan Suganthy
Biogenic synthesis of silver palladium bimetallic nanoparticles from fruit extract of Terminalia chebula – In vitro evaluation of anticancer and antimicrobial activity
description © 2019 Elsevier B.V. Biogenic synthesis of nanoparticles used for biomedical application has received much attention nowadays owing to its quick synthesis, cost effectiveness and biocompatible nature. The present study focuses on the biosynthesis of silver palladium bimetallic nanoparticles (AgPd NPs) from aqueous fruit extract of Terminalia chebula. Synthesized AgPd NP was assessed for antimicrobial activity and anticancer potential against lung cancer cells (A549). XRD analysis confirmed the formation of face centered cubic crystalline structure with average size of 20 nm, which was affirmed by DLS analysis. Uniform spherical shaped nanoparticles were observed in SEM and TEM analysis. Zeta potential value of −14.4 mV illustrated the stability of AgPd NPs. Anticancer studies illustrated that AgPd NPs induced ROS generation in lung cancer cells, thereby stimulating mitochondrial apoptotic pathway causing cell death. AgPd NPs exhibited antimicrobial activity against methicillin resistant Staphylococcus aureus and Pseudomonas aeruginosa. In vitro toxicity studies revealed that AgPd NPs exhibited no cyototoxic and hemolytic effect upto its maximum dose (200 μg/ml), ensuring the biocompatibility of nanoparticles. Our findings demonstrated that aqueous extract of T. chebula act as effective reducing and stabilizing agent for green synthesis of biocompatible AgPd NPs, which exhibits potent antimicrobial and anticancer activities.
format Journal
author Bhagavathi Sundaram Sivamaruthi
Vijayan Sri Ramkumar
Govindaraju Archunan
Chaiyavat Chaiyasut
Natarajan Suganthy
author_facet Bhagavathi Sundaram Sivamaruthi
Vijayan Sri Ramkumar
Govindaraju Archunan
Chaiyavat Chaiyasut
Natarajan Suganthy
author_sort Bhagavathi Sundaram Sivamaruthi
title Biogenic synthesis of silver palladium bimetallic nanoparticles from fruit extract of Terminalia chebula – In vitro evaluation of anticancer and antimicrobial activity
title_short Biogenic synthesis of silver palladium bimetallic nanoparticles from fruit extract of Terminalia chebula – In vitro evaluation of anticancer and antimicrobial activity
title_full Biogenic synthesis of silver palladium bimetallic nanoparticles from fruit extract of Terminalia chebula – In vitro evaluation of anticancer and antimicrobial activity
title_fullStr Biogenic synthesis of silver palladium bimetallic nanoparticles from fruit extract of Terminalia chebula – In vitro evaluation of anticancer and antimicrobial activity
title_full_unstemmed Biogenic synthesis of silver palladium bimetallic nanoparticles from fruit extract of Terminalia chebula – In vitro evaluation of anticancer and antimicrobial activity
title_sort biogenic synthesis of silver palladium bimetallic nanoparticles from fruit extract of terminalia chebula – in vitro evaluation of anticancer and antimicrobial activity
publishDate 2019
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85062542057&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/63752
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