Three New Polycyclic Containing Sulfur Compounds from the Seeds of Combretum quadrangulare Kurz (Combretaceae), Antifungal and Anti-mycobacterium activities

Three New Polycyclic Containing Sulfur Compounds from the Seeds of Combretum quadrangulare Kurz (Combretaceae), Antifungal and Anti-mycobacterium activities

Three new polycyclic containing sulfur compounds, Combretanoid, Combretanane and Combretanun, were isolated. The crude ethanolic extract and pure compound Combretin, the isolated pure compound from the seeds of Combretum quadrangulare Kurz (Combretaceae), showed antimicrobial activities against many...

Full description

Saved in:
Bibliographic Details
Main Authors: Khesorn Nantachit, Sasithorn Sirilun, Saksit Nobsathian, Somjing Rungjang
Format: บทความวารสาร
Language:English
Published: Science Faculty of Chiang Mai University 2019
Online Access:http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=7668
http://cmuir.cmu.ac.th/jspui/handle/6653943832/63841
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
Language: English
id th-cmuir.6653943832-63841
record_format dspace
spelling th-cmuir.6653943832-638412019-05-07T09:57:21Z Three New Polycyclic Containing Sulfur Compounds from the Seeds of Combretum quadrangulare Kurz (Combretaceae), Antifungal and Anti-mycobacterium activities Khesorn Nantachit Sasithorn Sirilun Saksit Nobsathian Somjing Rungjang Three new polycyclic containing sulfur compounds, Combretanoid, Combretanane and Combretanun, were isolated. The crude ethanolic extract and pure compound Combretin, the isolated pure compound from the seeds of Combretum quadrangulare Kurz (Combretaceae), showed antimicrobial activities against many pathogens. The aim of this study was to determine antifungal activity against opportunistic pathogens in HIV patients and anti-mycobacterium tuberculosis activity (anti-TB). An Antifungal test was performed by agar dilution method and an anti-TB test was done using green fluorescent protein microplate assay (GFPMA). Crude ethanolic extract from Amphur Sun Srai showed antifungal activity against A. fumigatus better than the extract from Amphur Sarapee. Combretanoid showed no antifungal activity and the three new compounds showed no anti-TB activity. This plant showed no toxicity to albino rat and mice. In conclusion, it may used as a traditional method for antifungal activity against A. fumigatus. 2019-05-07T09:57:21Z 2019-05-07T09:57:21Z 2017 บทความวารสาร 0125-2526 http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=7668 http://cmuir.cmu.ac.th/jspui/handle/6653943832/63841 Eng Science Faculty of Chiang Mai University
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Three new polycyclic containing sulfur compounds, Combretanoid, Combretanane and Combretanun, were isolated. The crude ethanolic extract and pure compound Combretin, the isolated pure compound from the seeds of Combretum quadrangulare Kurz (Combretaceae), showed antimicrobial activities against many pathogens. The aim of this study was to determine antifungal activity against opportunistic pathogens in HIV patients and anti-mycobacterium tuberculosis activity (anti-TB). An Antifungal test was performed by agar dilution method and an anti-TB test was done using green fluorescent protein microplate assay (GFPMA). Crude ethanolic extract from Amphur Sun Srai showed antifungal activity against A. fumigatus better than the extract from Amphur Sarapee. Combretanoid showed no antifungal activity and the three new compounds showed no anti-TB activity. This plant showed no toxicity to albino rat and mice. In conclusion, it may used as a traditional method for antifungal activity against A. fumigatus.
format บทความวารสาร
author Khesorn Nantachit
Sasithorn Sirilun
Saksit Nobsathian
Somjing Rungjang
spellingShingle Khesorn Nantachit
Sasithorn Sirilun
Saksit Nobsathian
Somjing Rungjang
Three New Polycyclic Containing Sulfur Compounds from the Seeds of Combretum quadrangulare Kurz (Combretaceae), Antifungal and Anti-mycobacterium activities
author_facet Khesorn Nantachit
Sasithorn Sirilun
Saksit Nobsathian
Somjing Rungjang
author_sort Khesorn Nantachit
title Three New Polycyclic Containing Sulfur Compounds from the Seeds of Combretum quadrangulare Kurz (Combretaceae), Antifungal and Anti-mycobacterium activities
title_short Three New Polycyclic Containing Sulfur Compounds from the Seeds of Combretum quadrangulare Kurz (Combretaceae), Antifungal and Anti-mycobacterium activities
title_full Three New Polycyclic Containing Sulfur Compounds from the Seeds of Combretum quadrangulare Kurz (Combretaceae), Antifungal and Anti-mycobacterium activities
title_fullStr Three New Polycyclic Containing Sulfur Compounds from the Seeds of Combretum quadrangulare Kurz (Combretaceae), Antifungal and Anti-mycobacterium activities
title_full_unstemmed Three New Polycyclic Containing Sulfur Compounds from the Seeds of Combretum quadrangulare Kurz (Combretaceae), Antifungal and Anti-mycobacterium activities
title_sort three new polycyclic containing sulfur compounds from the seeds of combretum quadrangulare kurz (combretaceae), antifungal and anti-mycobacterium activities
publisher Science Faculty of Chiang Mai University
publishDate 2019
url http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=7668
http://cmuir.cmu.ac.th/jspui/handle/6653943832/63841
_version_ 1681425970331910144

Similar Items