Protective Effect of Propolis Against Pulmonary Histological Alterations Induced by 10 nm Naked Gold Nanoparticles
Little is known about propolis protective effect against the toxicity induced by gold nanoparticles (GNPs). The present investigation was carried out to investigate the protective role of propolis against the histological alterations induced in the lung tissues by naked 10 nm GNPs. Male albino Wist...
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Science Faculty of Chiang Mai University
2019
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Online Access: | http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8020 http://cmuir.cmu.ac.th/jspui/handle/6653943832/63870 |
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th-cmuir.6653943832-638702019-05-07T09:59:36Z Protective Effect of Propolis Against Pulmonary Histological Alterations Induced by 10 nm Naked Gold Nanoparticles Mansour I. Almansour Bashir M. Jarrar Little is known about propolis protective effect against the toxicity induced by gold nanoparticles (GNPs). The present investigation was carried out to investigate the protective role of propolis against the histological alterations induced in the lung tissues by naked 10 nm GNPs. Male albino Wistar rats were exposed to 10 nm GNPs at a dose of 2 mg/kg together with or without propolis (50 mg/kg) for15 days. Lung biopsies from all rats under study were subjected to histological examinations. Exposure to 10 nm GNPs has induced thickened alveolar wall, inflammatory cells infiltration, interstitial macrophages invasion, emphysema, pulmonary edema, dilatation and congestion of the interalveolar capillaries, atelectasis and fibrocytes proliferation. Propolis combination with GNPs demonstrated full protection from pulmonary edema and alveolar hypersensitivity while the lung tissues were partially protected from interstitial thickening, inflammatory cells infiltration, emphysema, dilatation and congestion of the interalveolar capillaries. On the other hand, propolis failed to protect the lung tissues from fibrosis, macrophages invasion and atelectasis induced by GNPs. The findings indicated protective role for propolis against some histological damage in the pulmonary tissues induced by GNPs toxicity. 2019-05-07T09:59:36Z 2019-05-07T09:59:36Z 2017 บทความวารสาร 0125-2526 http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8020 http://cmuir.cmu.ac.th/jspui/handle/6653943832/63870 Eng Science Faculty of Chiang Mai University |
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Little is known about propolis protective effect against the toxicity induced by gold nanoparticles (GNPs). The present investigation was carried out to investigate the protective role of propolis against the histological alterations induced in the lung tissues by naked 10 nm GNPs. Male albino Wistar rats were exposed to 10 nm GNPs at a dose of 2 mg/kg together with or without propolis (50 mg/kg) for15 days. Lung biopsies from all rats under study were subjected to histological examinations. Exposure to 10 nm GNPs has induced thickened alveolar wall, inflammatory cells infiltration, interstitial macrophages invasion, emphysema, pulmonary edema, dilatation and congestion of the interalveolar capillaries, atelectasis and fibrocytes proliferation. Propolis combination with GNPs demonstrated full protection from pulmonary edema and alveolar hypersensitivity while the lung tissues were partially protected from interstitial thickening, inflammatory cells infiltration, emphysema, dilatation and congestion of the interalveolar capillaries. On the other hand, propolis failed to protect the lung tissues from fibrosis, macrophages invasion and atelectasis induced by GNPs. The findings indicated protective role for propolis against some histological damage in the pulmonary tissues induced by GNPs toxicity. |
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บทความวารสาร |
author |
Mansour I. Almansour Bashir M. Jarrar |
spellingShingle |
Mansour I. Almansour Bashir M. Jarrar Protective Effect of Propolis Against Pulmonary Histological Alterations Induced by 10 nm Naked Gold Nanoparticles |
author_facet |
Mansour I. Almansour Bashir M. Jarrar |
author_sort |
Mansour I. Almansour |
title |
Protective Effect of Propolis Against Pulmonary Histological Alterations Induced by 10 nm Naked Gold Nanoparticles |
title_short |
Protective Effect of Propolis Against Pulmonary Histological Alterations Induced by 10 nm Naked Gold Nanoparticles |
title_full |
Protective Effect of Propolis Against Pulmonary Histological Alterations Induced by 10 nm Naked Gold Nanoparticles |
title_fullStr |
Protective Effect of Propolis Against Pulmonary Histological Alterations Induced by 10 nm Naked Gold Nanoparticles |
title_full_unstemmed |
Protective Effect of Propolis Against Pulmonary Histological Alterations Induced by 10 nm Naked Gold Nanoparticles |
title_sort |
protective effect of propolis against pulmonary histological alterations induced by 10 nm naked gold nanoparticles |
publisher |
Science Faculty of Chiang Mai University |
publishDate |
2019 |
url |
http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8020 http://cmuir.cmu.ac.th/jspui/handle/6653943832/63870 |
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