Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb.

Natural products derived from endophytic microorganisms are one possible source for a new array of drug candidates. In this study, an endophytic Bacillus amyloliquefaciens UD25 was isolated and identified from a medicinal plant (Memecylon edule Roxb). Crude ethyl acetate extract of a whole culture o...

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Main Authors: Artidtaya Bhoonobtong, Sirirath Sodngam, Sophon Boonlue, Wandee Bunyatratchata, Wiyada Mongkolt
Format: บทความวารสาร
Language:English
Published: Science Faculty of Chiang Mai University 2019
Online Access:http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8268
http://cmuir.cmu.ac.th/jspui/handle/6653943832/63905
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-639052019-05-07T09:59:38Z Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb. Artidtaya Bhoonobtong Sirirath Sodngam Sophon Boonlue Wandee Bunyatratchata Wiyada Mongkolt Natural products derived from endophytic microorganisms are one possible source for a new array of drug candidates. In this study, an endophytic Bacillus amyloliquefaciens UD25 was isolated and identified from a medicinal plant (Memecylon edule Roxb). Crude ethyl acetate extract of a whole culture of B. amyloliquefaciens UD25 demonstrated growth inhibition of pathogenic bacteria, including Streptococcus sp., methicillin resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, Bacillus cereus and Escherichia coli. The antibiotic compounds were analyzed by GC-MS. Eighteen multifunctional natural product derivatives were identified including carboxylic acid and ester (1-4, 8-9, 12-13, 15), anthaquinone (5), alkaloids (7, 10-11), organohalogen (17), carbonyl (6,14, 16) and thiol (18). The antibiotic compounds observed by scanning electron microscope (SEM) had an impact on the cell membranes, which wilted and collapsed the cell surface. These results may lead to an alternative source of new antibacterial drugs candidates from endophytic bacteria. 2019-05-07T09:59:38Z 2019-05-07T09:59:38Z 2017 บทความวารสาร 0125-2526 http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8268 http://cmuir.cmu.ac.th/jspui/handle/6653943832/63905 Eng Science Faculty of Chiang Mai University
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Natural products derived from endophytic microorganisms are one possible source for a new array of drug candidates. In this study, an endophytic Bacillus amyloliquefaciens UD25 was isolated and identified from a medicinal plant (Memecylon edule Roxb). Crude ethyl acetate extract of a whole culture of B. amyloliquefaciens UD25 demonstrated growth inhibition of pathogenic bacteria, including Streptococcus sp., methicillin resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, Bacillus cereus and Escherichia coli. The antibiotic compounds were analyzed by GC-MS. Eighteen multifunctional natural product derivatives were identified including carboxylic acid and ester (1-4, 8-9, 12-13, 15), anthaquinone (5), alkaloids (7, 10-11), organohalogen (17), carbonyl (6,14, 16) and thiol (18). The antibiotic compounds observed by scanning electron microscope (SEM) had an impact on the cell membranes, which wilted and collapsed the cell surface. These results may lead to an alternative source of new antibacterial drugs candidates from endophytic bacteria.
format บทความวารสาร
author Artidtaya Bhoonobtong
Sirirath Sodngam
Sophon Boonlue
Wandee Bunyatratchata
Wiyada Mongkolt
spellingShingle Artidtaya Bhoonobtong
Sirirath Sodngam
Sophon Boonlue
Wandee Bunyatratchata
Wiyada Mongkolt
Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb.
author_facet Artidtaya Bhoonobtong
Sirirath Sodngam
Sophon Boonlue
Wandee Bunyatratchata
Wiyada Mongkolt
author_sort Artidtaya Bhoonobtong
title Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb.
title_short Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb.
title_full Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb.
title_fullStr Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb.
title_full_unstemmed Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb.
title_sort antibiotics constituents of endophytic bacillus amyloliquefaciens ud25 extracted from a medicinal plant, memecylon edule roxb.
publisher Science Faculty of Chiang Mai University
publishDate 2019
url http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8268
http://cmuir.cmu.ac.th/jspui/handle/6653943832/63905
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