Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb.
Natural products derived from endophytic microorganisms are one possible source for a new array of drug candidates. In this study, an endophytic Bacillus amyloliquefaciens UD25 was isolated and identified from a medicinal plant (Memecylon edule Roxb). Crude ethyl acetate extract of a whole culture o...
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Science Faculty of Chiang Mai University
2019
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th-cmuir.6653943832-639052019-05-07T09:59:38Z Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb. Artidtaya Bhoonobtong Sirirath Sodngam Sophon Boonlue Wandee Bunyatratchata Wiyada Mongkolt Natural products derived from endophytic microorganisms are one possible source for a new array of drug candidates. In this study, an endophytic Bacillus amyloliquefaciens UD25 was isolated and identified from a medicinal plant (Memecylon edule Roxb). Crude ethyl acetate extract of a whole culture of B. amyloliquefaciens UD25 demonstrated growth inhibition of pathogenic bacteria, including Streptococcus sp., methicillin resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, Bacillus cereus and Escherichia coli. The antibiotic compounds were analyzed by GC-MS. Eighteen multifunctional natural product derivatives were identified including carboxylic acid and ester (1-4, 8-9, 12-13, 15), anthaquinone (5), alkaloids (7, 10-11), organohalogen (17), carbonyl (6,14, 16) and thiol (18). The antibiotic compounds observed by scanning electron microscope (SEM) had an impact on the cell membranes, which wilted and collapsed the cell surface. These results may lead to an alternative source of new antibacterial drugs candidates from endophytic bacteria. 2019-05-07T09:59:38Z 2019-05-07T09:59:38Z 2017 บทความวารสาร 0125-2526 http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8268 http://cmuir.cmu.ac.th/jspui/handle/6653943832/63905 Eng Science Faculty of Chiang Mai University |
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Natural products derived from endophytic microorganisms are one possible source for a new array of drug candidates. In this study, an endophytic Bacillus amyloliquefaciens UD25 was isolated and identified from a medicinal plant (Memecylon edule Roxb). Crude ethyl acetate extract of a whole culture of B. amyloliquefaciens UD25 demonstrated growth inhibition of pathogenic bacteria, including Streptococcus sp., methicillin resistant Staphylococcus aureus (MRSA), Enterococcus faecalis, Bacillus cereus and Escherichia coli. The antibiotic compounds were analyzed by GC-MS. Eighteen multifunctional natural product derivatives were identified including carboxylic acid and ester (1-4, 8-9, 12-13, 15), anthaquinone (5), alkaloids (7, 10-11), organohalogen (17), carbonyl (6,14, 16) and thiol (18). The antibiotic compounds observed by scanning electron microscope (SEM) had an impact on the cell membranes, which wilted and collapsed the cell surface. These results may lead to an alternative source of new antibacterial drugs candidates from endophytic bacteria. |
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บทความวารสาร |
author |
Artidtaya Bhoonobtong Sirirath Sodngam Sophon Boonlue Wandee Bunyatratchata Wiyada Mongkolt |
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Artidtaya Bhoonobtong Sirirath Sodngam Sophon Boonlue Wandee Bunyatratchata Wiyada Mongkolt Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb. |
author_facet |
Artidtaya Bhoonobtong Sirirath Sodngam Sophon Boonlue Wandee Bunyatratchata Wiyada Mongkolt |
author_sort |
Artidtaya Bhoonobtong |
title |
Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb. |
title_short |
Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb. |
title_full |
Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb. |
title_fullStr |
Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb. |
title_full_unstemmed |
Antibiotics Constituents of Endophytic Bacillus amyloliquefaciens UD25 Extracted from a Medicinal Plant, Memecylon edule Roxb. |
title_sort |
antibiotics constituents of endophytic bacillus amyloliquefaciens ud25 extracted from a medicinal plant, memecylon edule roxb. |
publisher |
Science Faculty of Chiang Mai University |
publishDate |
2019 |
url |
http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8268 http://cmuir.cmu.ac.th/jspui/handle/6653943832/63905 |
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