Rheological Behavior and Physical Stability of Caffeine Loaded Water-in-oil Nanoemulsions

Rheological behavior and physical stability data of caffeine loaded water-in-oil (w/o) nanoemulsions have not been investigated. Therefore, the rheological behavior and physical stability of caffeine loaded w/o nanoemulsions were investigated in the present study. W/O nanoemulsions of caffeine were...

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Main Author: Faiyaz Shakeel
Format: บทความวารสาร
Language:English
Published: Science Faculty of Chiang Mai University 2019
Online Access:http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8293
http://cmuir.cmu.ac.th/jspui/handle/6653943832/63923
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spelling th-cmuir.6653943832-639232019-05-07T09:59:38Z Rheological Behavior and Physical Stability of Caffeine Loaded Water-in-oil Nanoemulsions Faiyaz Shakeel Rheological behavior and physical stability data of caffeine loaded water-in-oil (w/o) nanoemulsions have not been investigated. Therefore, the rheological behavior and physical stability of caffeine loaded w/o nanoemulsions were investigated in the present study. W/O nanoemulsions of caffeine were prepared by oil phase titration method and investigated for their rheological behavior. Optimized nanoemulsion was subjected to physical stability studies at 4 and 25 °C for the period of 3 months. The viscosity of prepared nanoemulsions was determined at different rate of shear using Cone and Plate Viscometer. The graph was plotted between shear stress Vs rate of shear and viscosity Vs rate of shear. The rheogram of prepared nanoemulsions (C1-C12) was observed as linear. The viscosity of all formulations was not changed by increasing the rate of shear which indicated Newtonian flow of prepared nanoemulsions. The droplet size, polydispersity index (PDI), viscosity and refractive index (RI) were determined for the period of three months. The droplet size was recorded in the range of 21.62-22.64 nm and 22.43-23.22 nm at 4 and 25 °C, respectively. No significant changes were recorded in droplet size, PDI, viscosity and RI of optimized nanoemulsions for the period of 3 months at both temperatures (P > 0.05). Results of these studies indicated that all the prepared nanoemulsions followed Newtonian behavior of flow and nanoemulsions can be used to enhance the stability of caffeine. 2019-05-07T09:59:38Z 2019-05-07T09:59:38Z 2017 บทความวารสาร 0125-2526 http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8293 http://cmuir.cmu.ac.th/jspui/handle/6653943832/63923 Eng Science Faculty of Chiang Mai University
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Rheological behavior and physical stability data of caffeine loaded water-in-oil (w/o) nanoemulsions have not been investigated. Therefore, the rheological behavior and physical stability of caffeine loaded w/o nanoemulsions were investigated in the present study. W/O nanoemulsions of caffeine were prepared by oil phase titration method and investigated for their rheological behavior. Optimized nanoemulsion was subjected to physical stability studies at 4 and 25 °C for the period of 3 months. The viscosity of prepared nanoemulsions was determined at different rate of shear using Cone and Plate Viscometer. The graph was plotted between shear stress Vs rate of shear and viscosity Vs rate of shear. The rheogram of prepared nanoemulsions (C1-C12) was observed as linear. The viscosity of all formulations was not changed by increasing the rate of shear which indicated Newtonian flow of prepared nanoemulsions. The droplet size, polydispersity index (PDI), viscosity and refractive index (RI) were determined for the period of three months. The droplet size was recorded in the range of 21.62-22.64 nm and 22.43-23.22 nm at 4 and 25 °C, respectively. No significant changes were recorded in droplet size, PDI, viscosity and RI of optimized nanoemulsions for the period of 3 months at both temperatures (P > 0.05). Results of these studies indicated that all the prepared nanoemulsions followed Newtonian behavior of flow and nanoemulsions can be used to enhance the stability of caffeine.
format บทความวารสาร
author Faiyaz Shakeel
spellingShingle Faiyaz Shakeel
Rheological Behavior and Physical Stability of Caffeine Loaded Water-in-oil Nanoemulsions
author_facet Faiyaz Shakeel
author_sort Faiyaz Shakeel
title Rheological Behavior and Physical Stability of Caffeine Loaded Water-in-oil Nanoemulsions
title_short Rheological Behavior and Physical Stability of Caffeine Loaded Water-in-oil Nanoemulsions
title_full Rheological Behavior and Physical Stability of Caffeine Loaded Water-in-oil Nanoemulsions
title_fullStr Rheological Behavior and Physical Stability of Caffeine Loaded Water-in-oil Nanoemulsions
title_full_unstemmed Rheological Behavior and Physical Stability of Caffeine Loaded Water-in-oil Nanoemulsions
title_sort rheological behavior and physical stability of caffeine loaded water-in-oil nanoemulsions
publisher Science Faculty of Chiang Mai University
publishDate 2019
url http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8293
http://cmuir.cmu.ac.th/jspui/handle/6653943832/63923
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