An Expeditious and Green Synthesis of 3,3¢-(Arylmethylene)-bis-(4-hydroxycoumarins) Catalyzed by 5-Sulfosalicylic Acid
The expeditious synthesis of 3,3¢-(arylmethylene)-bis-(4-hydroxycoumarins) via a three-component domino Knoevenagel-Michael reaction (3CDKMR) of various aldehydes and 4-hydroxycoumarin, catalyzed by 5-sulfosalicylic acid (SA) is explored. The reactions were conducted at 80 °C using water as a green...
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| Main Authors: | , |
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| Format: | บทความวารสาร |
| Language: | English |
| Published: |
Science Faculty of Chiang Mai University
2019
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| Online Access: | http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8288 http://cmuir.cmu.ac.th/jspui/handle/6653943832/63927 |
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| Institution: | Chiang Mai University |
| Language: | English |
| Summary: | The expeditious synthesis of 3,3¢-(arylmethylene)-bis-(4-hydroxycoumarins) via a three-component domino Knoevenagel-Michael reaction (3CDKMR) of various aldehydes and 4-hydroxycoumarin, catalyzed by 5-sulfosalicylic acid (SA) is explored. The reactions were conducted at 80 °C using water as a green and environmentally benign medium. The method has several advantages such as reusability of reaction medium, the avoidance of hazardous organic solvents, readily available reagents, cost-effectiveness, and good to high yields. |
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