Prevalence of the Multi-drug Resistance of Shiga Toxin-producing Escherichia coli Isolated from Pigs in Central Thailand

Shiga toxin-producing E. coli (STEC), a strain producing cytotoxins known as Shiga toxins (Stxs, encoded by EVS and EVC genes), can cause neonatal and post-weaning diarrhea (PWD) in pigs, leading to substantial economic loss in the form of medication costs, reduced growth rate, and increased morbidi...

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Main Authors: Shutipen Buranasinsup, Suphang Kulpeanprasit, Thida Kong-ngoen, Arunee Jangsangthong, Nitat Sookrung, Wanpen Chaicumpa, Nitaya Indrawattana
Format: บทความวารสาร
Language:English
Published: Science Faculty of Chiang Mai University 2019
Online Access:http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8726
http://cmuir.cmu.ac.th/jspui/handle/6653943832/64006
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spelling th-cmuir.6653943832-640062019-05-07T09:59:42Z Prevalence of the Multi-drug Resistance of Shiga Toxin-producing Escherichia coli Isolated from Pigs in Central Thailand Shutipen Buranasinsup Suphang Kulpeanprasit Thida Kong-ngoen Arunee Jangsangthong Nitat Sookrung Wanpen Chaicumpa Nitaya Indrawattana Shiga toxin-producing E. coli (STEC), a strain producing cytotoxins known as Shiga toxins (Stxs, encoded by EVS and EVC genes), can cause neonatal and post-weaning diarrhea (PWD) in pigs, leading to substantial economic loss in the form of medication costs, reduced growth rate, and increased morbidity and mortality. To tackle this, several antimicrobial agents are used in pig farms, although misuse may lead to occurrence of antimicrobial-resistant pathogens. In this study, 5,831 E. coli bacterial isolates were collected from 715 pigs. Of these, 206 bacterial isolates were STEC carrying EVS–EVC genes. A majority of the STECs were resistant to ampicillin (99.5%), carbenicillin (99%), and trimethoprim/sulfamethoxazole (60.2%). Among these isolates, 93.69% and 0.97% of STEC were carried class 1 (6.8% belong to CS1) and class 2 integrons, respectively. None isolate carried CS2. The predominant antimicrobial resistance genes were blaTEM, aadA, sulII, dhfrV, and intI. The results of antimicrobial resistance phenotype and also genotype were correlated to antibiotics use in the swine farm such as amoxicillin and penicillin. Therefore, frequent use of antimicrobial drugs in pig farms may result in the occurrence of multi-drug resistant bacteria, and this should be taken into consideration prior to use. 2019-05-07T09:59:42Z 2019-05-07T09:59:42Z 2018 บทความวารสาร 0125-2526 http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8726 http://cmuir.cmu.ac.th/jspui/handle/6653943832/64006 Eng Science Faculty of Chiang Mai University
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Shiga toxin-producing E. coli (STEC), a strain producing cytotoxins known as Shiga toxins (Stxs, encoded by EVS and EVC genes), can cause neonatal and post-weaning diarrhea (PWD) in pigs, leading to substantial economic loss in the form of medication costs, reduced growth rate, and increased morbidity and mortality. To tackle this, several antimicrobial agents are used in pig farms, although misuse may lead to occurrence of antimicrobial-resistant pathogens. In this study, 5,831 E. coli bacterial isolates were collected from 715 pigs. Of these, 206 bacterial isolates were STEC carrying EVS–EVC genes. A majority of the STECs were resistant to ampicillin (99.5%), carbenicillin (99%), and trimethoprim/sulfamethoxazole (60.2%). Among these isolates, 93.69% and 0.97% of STEC were carried class 1 (6.8% belong to CS1) and class 2 integrons, respectively. None isolate carried CS2. The predominant antimicrobial resistance genes were blaTEM, aadA, sulII, dhfrV, and intI. The results of antimicrobial resistance phenotype and also genotype were correlated to antibiotics use in the swine farm such as amoxicillin and penicillin. Therefore, frequent use of antimicrobial drugs in pig farms may result in the occurrence of multi-drug resistant bacteria, and this should be taken into consideration prior to use.
format บทความวารสาร
author Shutipen Buranasinsup
Suphang Kulpeanprasit
Thida Kong-ngoen
Arunee Jangsangthong
Nitat Sookrung
Wanpen Chaicumpa
Nitaya Indrawattana
spellingShingle Shutipen Buranasinsup
Suphang Kulpeanprasit
Thida Kong-ngoen
Arunee Jangsangthong
Nitat Sookrung
Wanpen Chaicumpa
Nitaya Indrawattana
Prevalence of the Multi-drug Resistance of Shiga Toxin-producing Escherichia coli Isolated from Pigs in Central Thailand
author_facet Shutipen Buranasinsup
Suphang Kulpeanprasit
Thida Kong-ngoen
Arunee Jangsangthong
Nitat Sookrung
Wanpen Chaicumpa
Nitaya Indrawattana
author_sort Shutipen Buranasinsup
title Prevalence of the Multi-drug Resistance of Shiga Toxin-producing Escherichia coli Isolated from Pigs in Central Thailand
title_short Prevalence of the Multi-drug Resistance of Shiga Toxin-producing Escherichia coli Isolated from Pigs in Central Thailand
title_full Prevalence of the Multi-drug Resistance of Shiga Toxin-producing Escherichia coli Isolated from Pigs in Central Thailand
title_fullStr Prevalence of the Multi-drug Resistance of Shiga Toxin-producing Escherichia coli Isolated from Pigs in Central Thailand
title_full_unstemmed Prevalence of the Multi-drug Resistance of Shiga Toxin-producing Escherichia coli Isolated from Pigs in Central Thailand
title_sort prevalence of the multi-drug resistance of shiga toxin-producing escherichia coli isolated from pigs in central thailand
publisher Science Faculty of Chiang Mai University
publishDate 2019
url http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8726
http://cmuir.cmu.ac.th/jspui/handle/6653943832/64006
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