Hypoglycemic Activity and Acute Toxicity of Human Insulin-tat Mixture

• Main Authors: Aranya Manosroi, Chanutchamon Sutthiwanjampa, Worapaka Manosroi, Rolf G. Werner, Friedrich Götz, Theeraphong Tangjai, Worapong Kitdamrongtham, Jiradej Manosroi
• Format: บทความวารสาร
• Language: English
• Published: Science Faculty of Chiang Mai University 2019
• Online Access: http://it.science.cmu.ac.th/ejournal/dl.php?journal_id=8742; http://cmuir.cmu.ac.th/jspui/handle/6653943832/64021
• Institution: Chiang Mai University

When orally administered in fasted alloxan-induced diabetic mice, human insulin mixed with the cell penetrating peptides, the trans-activator of transcription (Tat) gave the hypoglycemic activity, while mixed with the VP1-BC loop polioviral capsid (VP) showed no hypoglycemic activity. The insulin-Ta...