Stress adaptation in Talaromyces marneffei
Chiang Mai Medical Journal (Formerly Chiang Mai Medical Bulletin) is an official journal of the Faculty of Medicine, Chiang Mai University. It accepts original papers on clinical and experimental research that are pertinent in the biomedical sciences. The Journal is published 4 issues/year (i.e., Ma...
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Faculty of Medicine, Chiang Mai University
2019
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| Online Access: | https://www.tci-thaijo.org/index.php/CMMJ-MedCMJ/article/view/87752/69223 http://cmuir.cmu.ac.th/jspui/handle/6653943832/65031 |
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th-cmuir.6653943832-650312019-05-07T10:02:37Z Stress adaptation in Talaromyces marneffei การปรับตัวเข้ากับสภาวะเครียดในเชื้อ Talaromyces marneffei Monsicha Pongpom Nongnuch Vanittanakom Chiang Mai Medical Journal (Formerly Chiang Mai Medical Bulletin) is an official journal of the Faculty of Medicine, Chiang Mai University. It accepts original papers on clinical and experimental research that are pertinent in the biomedical sciences. The Journal is published 4 issues/year (i.e., Mar, Jun, Sep, and Dec). Talaromyces marneffei (T. marneffei) (previously named Penicillium marneffei) is a thermal dimorphic fungus that causes disseminated infection, which is common in AIDS patients, especially in northern Thailand. This fungus has the ability to survive in a host macrophage, which is the virulence factor attributed to promoting pathogenicity. At present, understanding of T. marneffei stress response in vivo is limited. Therefore, this study analyzed genes that are responsible for stress. They are highly expressed during the pathogenic yeast phase and encoded antigenic proteins of T. marneffei. Expression patterns of genes encoded for heat shock protein 30, glutathione peroxidase, cytochrome c oxidase and NADH-ubiquinone oxidoreductase were different in the mold, conidial and yeast phase. Interestingly, genes responsible for heat shock and nutrient starvation had lowest activity in the mold phase instead of the conidial phase. This result suggested that, even in the dormant stage, the conidia of this fungus prepared the genes responsible for several stresses, and they may play a role in the germination and survival process during infection. This study hypothesized that this pathogen has the ability to resist complex and dynamic host niches by occupying alternative carbon sources and having simultaneous response to heat and oxidative stresses inside the host. 2019-05-07T10:02:37Z 2019-05-07T10:02:37Z 2016 บทความวารสาร 0125-5983 https://www.tci-thaijo.org/index.php/CMMJ-MedCMJ/article/view/87752/69223 http://cmuir.cmu.ac.th/jspui/handle/6653943832/65031 Eng Faculty of Medicine, Chiang Mai University |
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Chiang Mai University |
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Chiang Mai University Library |
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English |
| description |
Chiang Mai Medical Journal (Formerly Chiang Mai Medical Bulletin) is an official journal of the Faculty of Medicine, Chiang Mai University. It accepts original papers on clinical and experimental research that are pertinent in the biomedical sciences. The Journal is published 4 issues/year (i.e., Mar, Jun, Sep, and Dec). |
| format |
บทความวารสาร |
| author |
Monsicha Pongpom Nongnuch Vanittanakom |
| spellingShingle |
Monsicha Pongpom Nongnuch Vanittanakom Stress adaptation in Talaromyces marneffei |
| author_facet |
Monsicha Pongpom Nongnuch Vanittanakom |
| author_sort |
Monsicha Pongpom |
| title |
Stress adaptation in Talaromyces marneffei |
| title_short |
Stress adaptation in Talaromyces marneffei |
| title_full |
Stress adaptation in Talaromyces marneffei |
| title_fullStr |
Stress adaptation in Talaromyces marneffei |
| title_full_unstemmed |
Stress adaptation in Talaromyces marneffei |
| title_sort |
stress adaptation in talaromyces marneffei |
| publisher |
Faculty of Medicine, Chiang Mai University |
| publishDate |
2019 |
| url |
https://www.tci-thaijo.org/index.php/CMMJ-MedCMJ/article/view/87752/69223 http://cmuir.cmu.ac.th/jspui/handle/6653943832/65031 |
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