The effect of dexmedetomidine on the vagolytic effect of pancuronium during propofol induction
Chiang Mai Medical Journal (Formerly Chiang Mai Medical Bulletin) is an official journal of the Faculty of Medicine, Chiang Mai University. It accepts original papers on clinical and experimental research that are pertinent in the biomedical sciences. The Journal is published 4 issues/year (i.e., Ma...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | บทความวารสาร |
| Language: | English |
| Published: |
Faculty of Medicine, Chiang Mai University
2019
|
| Online Access: | https://www.tci-thaijo.org/index.php/CMMJ-MedCMJ/article/view/92738/72621 http://cmuir.cmu.ac.th/jspui/handle/6653943832/65054 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Chiang Mai University |
| Language: | English |
| id |
th-cmuir.6653943832-65054 |
|---|---|
| record_format |
dspace |
| spelling |
th-cmuir.6653943832-650542019-05-07T10:02:38Z The effect of dexmedetomidine on the vagolytic effect of pancuronium during propofol induction ผลของยาเด็กซ์เมดิโทมิดีนต่อการออกฤทธิ์เวโกลัยติกของยาแพนคูโรเนียม ระหว่างการนำสลบด้วยยาโพรโพฟอล Worawut Lapisatepun Tanyong Pipanmekaporn Tanyong Pipanmekaporn Kanchana Wisadekarn Chiang Mai Medical Journal (Formerly Chiang Mai Medical Bulletin) is an official journal of the Faculty of Medicine, Chiang Mai University. It accepts original papers on clinical and experimental research that are pertinent in the biomedical sciences. The Journal is published 4 issues/year (i.e., Mar, Jun, Sep, and Dec). Objective To determine the effect of dexmedetomidine on the vagolytic effect of pancuronium during propofol induction and the hemodynamic responses to intubation in normotensive patients plus the effects of dexmedetomidine on the action of pancuronium Methods Forty-four American Society of Anesthesiologists (ASA) class I and II adults were included in this randomized, double-blind controlled trial. Patients with hypertension or preexisting bradycardia/ tachycardia were excluded from the study. On arrival at the operating room, participating patients received a 20 ml infusion of either saline (Group C, n=22) or Dexmedetomidine 0.7 μg/kg (Group D, n=22) over a period of 10 minutes followed by propofol induction. Calibration of the twitch response of the adductor pollicis muscle was then performed followed by injection of pancuronium 0.12 mg/kg. Endotracheal intubation was accomplished 2.5 minutes after the injection. Initial blood pressure (BP) and heart rate (HR) were measured and recorded for baseline control. BP and HR were measured again at completion of drug infusion, 2.5 minutes after pancuronium, immediately after intubation, and then each minute for the next 5 minutes for a total of 5 times (T0-T5). Also recorded was the twitch height of the adductor pollicis muscle at the time of intubation and the duration of action of pancuronium. Results The HR in Group D was lower than that of Group C at 2.5 minutes after pancuronium (75.7±9.3 vs 88±12.9 bpm, p=0.013) but not different from its baseline. After intubation, HR at T0-T5 were comparable between groups. BP did not differ signifi cantly between the groups during the entire study. In Group C, however, systolic BP at just before intubation was signifi cantly lower than baseline (106.4±12.0 vs 121.0±13.9 mmHg, p=0.001). None of the patients needed treatment for hypo/hypertension or brady/tachycardia. At the time of intubation, Group D had a higher percentage of patients with a twitch height <10% than Group C (92 vs 67%, p=0.048). The duration of action of pancuronium was not different between the groups. Conclusions In normotensive patients, dexmedetomidine 0.7μg/kg infusion prior to propofol induction effectively reduces the vagolytic effect of pancuronium prior to intubation but does not blunt the blood pressure responses to intubation. It also quickens the onset of pancuronium but has no effect on its duration. 2019-05-07T10:02:38Z 2019-05-07T10:02:38Z 2017 บทความวารสาร 0125-5983 https://www.tci-thaijo.org/index.php/CMMJ-MedCMJ/article/view/92738/72621 http://cmuir.cmu.ac.th/jspui/handle/6653943832/65054 Eng Faculty of Medicine, Chiang Mai University |
| institution |
Chiang Mai University |
| building |
Chiang Mai University Library |
| country |
Thailand |
| collection |
CMU Intellectual Repository |
| language |
English |
| description |
Chiang Mai Medical Journal (Formerly Chiang Mai Medical Bulletin) is an official journal of the Faculty of Medicine, Chiang Mai University. It accepts original papers on clinical and experimental research that are pertinent in the biomedical sciences. The Journal is published 4 issues/year (i.e., Mar, Jun, Sep, and Dec). |
| format |
บทความวารสาร |
| author |
Worawut Lapisatepun Tanyong Pipanmekaporn Tanyong Pipanmekaporn Kanchana Wisadekarn |
| spellingShingle |
Worawut Lapisatepun Tanyong Pipanmekaporn Tanyong Pipanmekaporn Kanchana Wisadekarn The effect of dexmedetomidine on the vagolytic effect of pancuronium during propofol induction |
| author_facet |
Worawut Lapisatepun Tanyong Pipanmekaporn Tanyong Pipanmekaporn Kanchana Wisadekarn |
| author_sort |
Worawut Lapisatepun |
| title |
The effect of dexmedetomidine on the vagolytic effect
of pancuronium during propofol induction |
| title_short |
The effect of dexmedetomidine on the vagolytic effect
of pancuronium during propofol induction |
| title_full |
The effect of dexmedetomidine on the vagolytic effect
of pancuronium during propofol induction |
| title_fullStr |
The effect of dexmedetomidine on the vagolytic effect
of pancuronium during propofol induction |
| title_full_unstemmed |
The effect of dexmedetomidine on the vagolytic effect
of pancuronium during propofol induction |
| title_sort |
effect of dexmedetomidine on the vagolytic effect
of pancuronium during propofol induction |
| publisher |
Faculty of Medicine, Chiang Mai University |
| publishDate |
2019 |
| url |
https://www.tci-thaijo.org/index.php/CMMJ-MedCMJ/article/view/92738/72621 http://cmuir.cmu.ac.th/jspui/handle/6653943832/65054 |
| _version_ |
1681426197185036288 |