Importance of the Cys¹²⁴−Cys¹²⁸ intermolecular disulfide bonding for oligomeric assembly and hemolytic activity of the Helicobacter pylori TlyA hemolysin

• Main Authors: Nitchakan Samainukul, Aung Khine Linn, Mohammad Bagher Javadi, Somsri Sakdee, Chanan Angsuthanasombat, Gerd Katzenmeier
• Format: Journal
• Published: 2019
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85064744482&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/65364
• Institution: Chiang Mai University

© 2019 Elsevier Inc. Although the TlyA hemolysin from Helicobacter pylori has been implicated as a potential virulence factor involved in mediating host cell colonization and hence disease progression, its structural determinants underlying the biological activity are still largely uncertain. In thi...