Influence of CYP3A5 and SLCO1B1 polymorphisms on atazanavir/r concentrations in Thai HIV-infected patients

• Main Authors: Noppaket Singkham, Anchalee Avihingsanon, Narukjaporn Thammajaruk, Kiat Ruxrungtham, Torsak Bunupuradah, Sasisopin Kiertiburanakul, Ploenchan Chetchotisakd, David M. Burger, Sean Emery, Baralee Punyawudho
• Format: Journal
• Published: 2019
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85066117677&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/65380
• Institution: Chiang Mai University

© 2019 Future Medicine Ltd. Aim: To evaluate the influence of genetic polymorphisms on plasma trough concentrations of atazanavir (ATV) and ritonavir (RTV). Patients & methods: The concentration-to-dose ratios were compared between different genotype groups of CYP3A5, ABCB1, SLCO1B1 and NR1I2 in...