Non-proteasomal UbL-UbA family of proteins in neurodegeneration

• Main Authors: Salinee Jantrapirom, Luca Lo Piccolo, Masamitsu Yamaguchi
• Format: Journal
• Published: 2019
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemical Engineering; Chemistry; Computer Science
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85065092767&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/65385
• Institution: Chiang Mai University

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Ubiquitin-like/ubiquitin-associated proteins (UbL-UbA) are a well-studied family of non-proteasomal ubiquitin receptors that are evolutionarily conserved across species. Members of this non-homogenous family facilitate and support proteasomal activity by promoting different effects on proteostasis but exhibit diverse extra-proteasomal activities. Dysfunctional UbL-UbA proteins render cells, particularly neurons, more susceptible to stressors or aging and may cause earlier neurodegeneration. In this review, we summarized the properties and functions of UbL-UbA family members identified to date, with an emphasis on new findings obtained using Drosophila models showing a direct or indirect role in some neurodegenerative diseases.